Jie Yang

发表

Synthesis, in vitro and in vivo biological evaluation, docking studies, and structure--activity relationship (SAR) discussion of dipeptidyl boronic acid proteasome inhibitors composed of beta-amino acids.

L. Zhang, Zhen-ming Liu, Xinrong Zhu, 2010, Journal of medicinal chemistry.

Application of synergistic β-lactamase inhibitors and antibiotics in the treatment of wounds infected by superbugs

Weiyun Wang, Jing Su, Jie Yang, 2022, Arabian Journal of Chemistry.

Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.

M. Ihnat, A. Gangjee, Jie Yang, 2003, Bioorganic & medicinal chemistry.

Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.

Xinrong Zhu, Qingzhi Gao, Gang Wu, 2009, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids.

Xinrong Zhu, Gang Wu, Meng Lei, 2010, Journal of medicinal chemistry.

Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors.

Yanliang Ren, Wei Huang, H. Xiang, 2015, Bioorganic & medicinal chemistry.

Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of PARP1 for Treating Cancers.

Lifeng Zhao, Yong Chen, Jie Yang, 2020, Journal of medicinal chemistry.

Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors.

Qianbin Li, Gaoyun Hu, Zutao Yu, 2019, Bioorganic & medicinal chemistry.

Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold.

Xinyu R. Ma, Yuanyuan Liu, Jie Yang, 2021, European journal of medicinal chemistry.

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.

A. Gangjee, J. McGuire, R. Kisliuk, 2006, Bioorganic & medicinal chemistry.

Discovery of 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo.

Rui Li, Yuanyuan Liu, Jie Yang, 2022, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationship of dihydrobenzoquinolines as novel inhibitors against influenza A virus.

Qiuhua Zhu, Hui Liao, Jie Yang, 2022, European journal of medicinal chemistry.

Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds.

W. Miller, W. Li, Yibin Zeng, 2004, Biochemical pharmacology.

Discovery of 4-(3,5-dimethoxy-4-(((4-methoxyphenethyl)amino)methyl)phenoxy)-N-phenylaniline as a novel c-myc inhibitor against colorectal cancer in vitro and in vivo.

Xinyu R. Ma, Yuanyuan Liu, Jie Yang, 2020, European journal of medicinal chemistry.

Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.

S. Queener, A. Gangjee, Jie Yang, 2006, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.

Yan Li, Zhenghuai Tan, Yong Deng, 2018, Bioorganic & medicinal chemistry.

Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-d] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3-d] Pyrimidine on Antifolate Activity

A. Gangjee, J. McGuire, R. Kisliuk, 2002 .

Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.

A. Gangjee, Wei Li, R. Kisliuk, 2008, Journal of medicinal chemistry.

Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors.

Rui Li, Lifeng Zhao, Jie Yang, 2019, European journal of medicinal chemistry.

Discovery of a PROTAC targeting ALK with in vivo activity.

Jie Yang, Meng Zhou, Rui Li, 2021, European journal of medicinal chemistry.

Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.

Wen-en Zhao, Lina Ding, Liying Ma, 2019, Journal of medicinal chemistry.

A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm.

P. Portoghese, M. M. Lunzer, Jie Yang, 2011, ACS medicinal chemistry letters.

Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin.

Qianbin Li, Gaoyun Hu, F. Huang, 2020, Journal of medicinal chemistry.

Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.

K. Anderson, S. Queener, A. Gangjee, 2013, ACS medicinal chemistry letters.

N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.

M. Ihnat, J. Thorpe, Sudhir Raghavan, 2012, Bioorganic & medicinal chemistry.