Yongmi An

发表

Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune Diseases

A. Yamniuk, S. Grant, J. Bryson, 2014, The Journal of Immunology.

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.

L. Hamann, A. Fura, R. Seethala, 2006, Journal of medicinal chemistry.

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

K. Kish, S. Krystek, Donna D Wei, 2005, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.

J. Fargnoli, J. Tokarski, G. Trainor, 2010, Bioorganic & medicinal chemistry letters.

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.

David S. Nirschl, David S Nirschl, J. Fargnoli, 2008, Bioorganic & medicinal chemistry letters.

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.

J. Fargnoli, J. Tokarski, J. Hunt, 2008, Bioorganic & medicinal chemistry letters.

Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis.

J. Barrish, C. Cavallaro, A. Tebben, 2014, Journal of medicinal chemistry.

Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.

C. Chu, G. Mintier, J. Feder, 2007, Protein expression and purification.

N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.

K. Kish, L. Hamann, A. Fura, 2009, Journal of medicinal chemistry.

Integral Repeats and a Continuous Coiled Coil Are Required for Binding of Striated Muscle Tropomyosin to the Regulated Actin Filament (*)

S. Hitchcock-DeGregori, Yongmi An, 1996, The Journal of Biological Chemistry.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

J. Fargnoli, J. Tokarski, D. Xie, 2008, Journal of medicinal chemistry.

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

Howard M. Einspahr, Stanley R. Krystek, K. Kish, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

Stanley R Krystek, Jacek Ostrowski, K. Kish, 2007, Endocrinology.

Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR.

Eric T Baldwin, Martin C. Wright, Andrew J Tebben, 2015, Journal of molecular biology.

Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.

A. Yamniuk, S. Sheriff, S. Grant, 2016, Journal of molecular biology.

Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).

Zheng Yang, Neha Surti, Jonathan S Lippy, 2015, Bioorganic & medicinal chemistry letters.

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Andrew Tebben, Qian Ruan, Neha Surti, 2014, Bioorganic & medicinal chemistry letters.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Wei Wang, Jun Li, Ying Wang, 2010, Journal of medicinal chemistry.

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

K. Kish, S. Krystek, M. Salvati, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

Diseases Antibody for Treatment of Autoimmune Engineering of a Novel Anti-CD 40 L Domain

A. Yamniuk, S. Grant, J. Bryson, 2014 .

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019 .

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019, Bioorganic & medicinal chemistry letters.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.