Y. Hakeda

发表

Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells.

T. Kameda, K. Ikeda, H. Kawashima, 1998, Biochemical and biophysical research communications.

Fibroblast Growth Factor (FGF)-2 Directly Stimulates Mature Osteoclast Function through Activation of FGF Receptor 1 and p42/p44 MAP Kinase*

Kozo Nakamura, T. Takato, H. Kawaguchi, 2000, The Journal of Biological Chemistry.

Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op/op) mice by a single injection of macrophage colony‐stimulating factor

S. Niida, H. Kawashima, H. Kodama, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors

Junta Ito, Y. Hakeda, Yoko Ohyama, 2018, PloS one.

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

M. Kumegawa, T. Sato, H. Kamioka, 1994, The Journal of biological chemistry.

Effects of parathyroid hormone on cAMP production and alkaline phosphatase activity in osteoblastic clone MC3T3-E1 cells.

N. Kurihara, M. Kumegawa, Y. Hakeda, 1984, Biochemical and biophysical research communications.

Divalent cations elevate cytosolic calcium of chick osteocytes.

K. Sumitani, M. Kumegawa, H. Kamioka, 1994, Biochemical and biophysical research communications.

Low-density Lipoprotein Receptor Deficiency Causes Impaired Osteoclastogenesis and Increased Bone Mass in Mice because of Defect in Osteoclastic Cell-Cell Fusion*

M. Masuhara, Junta Ito, N. Suda, 2012, The Journal of Biological Chemistry.

Tandem muscle-spindle in the masseter muscle of mice

M. Kumegawa, Y. Hakeda, N. Maeda, 1986 .

Dexamethasone inhibits bone resorption by indirectly inducing apoptosis of the bone-resorbing osteoclasts via the action of osteoblastic cells

M. Kumegawa, Y. Hakeda, Shintaro Warabi, 2004, Cytotechnology.

Dexamethasone Enhances Osteoclast Formation Synergistically with Transforming Growth Factor-β by Stimulating the Priming of Osteoclast Progenitors for Differentiation into Osteoclasts*

M. Kumegawa, S. Ninomiya, Y. Hakeda, 2003, Journal of Biological Chemistry.

Estrogen directly down-regulates the bone-resorbing activity of mature osteoclasts through nuclear estrogen receptor α

M. Kumegawa, H. Mano, Y. Hakeda, 2004, Cytotechnology.

Human calcitonin has the same inhibitory effect on osteoclastic bone resorption by human giant cell tumor cells as salmon calcitonin

M. Kumegawa, S. Kakudo, Y. Kitajima, 1996, Calcified Tissue International.

Apoptosis-inducing activity of vitamin C and vitamin K.

H. Sakagami, K. Satoh, M. Kumegawa, 2000, Cellular and molecular biology.

Stimulatory effect of a phorbol ester on expression of insulin‐like growth factor (IGF) binding protein‐2 and level of IGF‐I receptors in mouse osteoblastic MC3T3‐E1 cells

M. Hurley, H. Kawaguchi, M. Kumegawa, 1994, Journal of cellular physiology.

Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae.

H. Kawaguchi, L. Raisz, O. Voznesensky, 1994, Endocrinology.

Insulin-like growth factor-I supports formation and activation of osteoclasts.

M. Kumegawa, T. Sato, Y. Hakeda, 1992, Endocrinology.

Receptor activator of NF-κB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein.

M. Masuhara, Chihiro Koike, Junta Ito, 2012, Bone.

Generation of osteoclasts from isolated hematopoietic progenitor cells.

H. Nakauchi, T. Suda, N. Kurihara, 1989, Blood.

[Osteoclasts in bone metabolism].

M. Kumegawa, Y. Hakeda, 1991, Kaibogaku zasshi. Journal of anatomy.

Mouse osteoblastic cells (MC3T3-E1) at different stages of differentiation have opposite effects on osteoclastic cell formation.

K. Sumitani, M. Kumegawa, T. Sato, 1991, Endocrinology.

Effects of diastereoisomers of 1,25-dihydroxyvitamin D3-26,23-lactone on alkaline phosphatase and collagen synthesis in osteoblastic cells

N. Kurihara, A. Norman, K. Ikeda, 1988, Molecular and Cellular Endocrinology.

Direct and Indirect Actions of Fibroblast Growth Factor 2 on Osteoclastic Bone Resorption in Cultures

Kozo Nakamura, H. Kawaguchi, M. Kumegawa, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells

T. Ogasawara, T. Sawamura, A. Kakino, 2020, Journal of Cell Science.

Endogenous Production of TGF-β Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-κB Ligand and Macrophage-Colony- Stimulating Factor1

M. Kumegawa, H. Mano, Y. Hakeda, 2000, The Journal of Immunology.

Factor StimulatingLigand and Macrophage-Colony-B κ Combination of Receptor Activator of NF-for Osteoclastogenesis Induced by a Is Essential β Endogenous Production of TGF -

M. Kumegawa, H. Mano, Y. Hakeda, 2000 .

Regulation of receptor activator of NF-kappa B ligand-induced osteoclastogenesis by endogenous interferon-beta (INF-beta ) and suppressors of cytokine signaling (SOCS). The possible counteracting role of SOCSs- in IFN-beta-inhibited osteoclast formation.

M. Kumegawa, Y. Toyama, Y. Hakeda, 2002, The Journal of biological chemistry.

Effect of forskolin on collagen production in clonal osteoblastic MC3T3-E1 cells.

N. Kurihara, M. Kumegawa, Y. Hakeda, 1987, Journal of biochemistry.

Prostaglandin E1 and F2 alpha stimulate differentiation and proliferation, respectively, of clonal osteoblastic MC3T3-E1 cells by different second messengers in vitro.

N. Kurihara, M. Kumegawa, Y. Hakeda, 1987, Endocrinology.

Osteoclastogenesis inhibitory factor (OCIF) directly inhibits bone-resorbing activity of isolated mature osteoclasts.

M. Kumegawa, T. Miyata, H. Yasuda, 1998, Biochemical and biophysical research communications.

Identification of matrix metalloproteinase 9 in rabbit osteoclasts.

H. Kawashima, M. Kumegawa, T. Sato, 1994, The Journal of biological chemistry.

Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts

M. Kumegawa, T. Arakawa, Y. Hakeda, 2000, FEBS letters.

Mechanism of Stimulation of Osteoclastic Bone Resorption through Gas6/Tyro 3, a Receptor Tyrosine Kinase Signaling, in Mouse Osteoclasts*

Kozo Nakamura, T. Takato, T. Ogasawara, 2001, The Journal of Biological Chemistry.

Effects of transforming growth factor-β1 on formation and activation of osteoclasts

K. Sumitani, M. Kumegawa, H. Kamioka, 1995, Journal of Bone and Mineral Metabolism.

Retinoic acid directly stimulates osteoclastic bone resorption and gene expression of cathepsin K/OC-2.

S. Kakudo, T. Yamada, A. Itabashi, 1995, The Biochemical journal.

Down‐Regulation of Gap Junctional Intercellular Communication Between Osteoblastic MC3T3‐E1 Cells by Basic Fibroblast Growth Factor and a Phorbol Ester (12‐O‐Tetradecanoylphorbol‐13‐Acetate)

T. Kameda, M. Kumegawa, S. Kakudo, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Murine recombinant leukemia inhibitory factor modulates inhibitory effect of 1,25 dihydroxyvitamin D3 on alkaline phosphatase activity in MC3T3-E1 cells.

H. Kodama, M. Kumegawa, K. Tanaka, 1991, Biochemical and biophysical research communications.

Prostaglandins and bone cell activity

M. Kumegawa, Y. Hakeda, 1988, Journal of Bone and Mineral Metabolism.

Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.

T. Ogasawara, T. Sawamura, A. Kakino, 2015, Bone.

Basic fibroblast growth factor regulates IGF‐I binding proteins in the clonal osteoblastic cell line MC3T3‐E1

M. Hurley, Y. Hakeda, C. Abreu, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Intact insulin‐like growth factor binding protein‐5 (IGFBP‐5) associates with bone matrix and the soluble fragments of IGFBP‐5 accumulated in culture medium of neonatal mouse calvariae by parathyroid hormone and prostaglandin E2‐treatment

S. Mohan, M. Hurley, M. Kumegawa, 1996, Journal of cellular physiology.

Biological activity assessment of 1 alpha,25-dihydroxyvitamin D3-26,23-lactone and its intermediate metabolites in vivo and in vitro.

K. Sumitani, M. Kumegawa, K. Hiura, 1990, Endocrinology.

Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro

Ken Watanabe, M. Masuhara, Y. Hakeda, 2006, Journal of Bone and Mineral Metabolism.

Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-κB p50/p65

M. Masuhara, Y. Hakeda, Takuya Sato, 2009, Journal of Bone and Mineral Metabolism.

Hepatocyte growth factor is involved in formation of osteoclast‐like cells mediated by clonal stromal cells (MC3T3‐G2/PA6)

Y. Yamaguchi, Toshikazu Nakamura, K. Sumitani, 1995, Journal of cellular physiology.

Tyro 3 Receptor Tyrosine Kinase and its Ligand, Gas6, Stimulate the Function of Osteoclasts

T. Kameda, N. Takakura, T. Miyamoto, 1998, Stem cells.

IFN-ζ /limitin Inhibits Generation of Osteoclast Precursors

M. Masuhara, Y. Hakeda, Takuya Sato, 2009 .

Concanavalin A directly stimulates bone-resorbing activity of osteoclasts and their gene expression of cathepsin K/OC-2.

M. Kumegawa, S. Kakudo, H. Mano, 1997, Biochemical and biophysical research communications.

Calcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts.

K. Chihara, M. Fukase, H. Kaji, 1994, Endocrinology.

Mammalian mature osteoclasts as estrogen target cells.

T. Kameda, M. Kumegawa, T. Yamada, 1996, Biochemical and biophysical research communications.

Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts.

M. Kumegawa, Y. Toyama, T. Arakawa, 2000, Bone.

Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

M. Kumegawa, T. Kameda, N. Yang, 1997, The Journal of experimental medicine.

Fluid Shear Stress-induced Cyclooxygenase-2 Expression Is Mediated by C/EBP β, cAMP-response Element-binding Protein, and AP-1 in Osteoblastic MC3T3-E1 Cells*

M. Kumegawa, T. Arakawa, T. Takuma, 2001, The Journal of Biological Chemistry.

Identification of osteopontin in isolated rabbit osteoclasts.

P. Nijweide, N. Kurihara, M. Kumegawa, 1992, Biochemical and biophysical research communications.

Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.

H. Kawaguchi, L. Raisz, O. Voznesensky, 1993, The Journal of biological chemistry.

Isolated chick osteocytes stimulate formation and bone-resorbing activity of osteoclast-like cells

Y. Yamaguchi, Y. Hakeda, Kayo Tanaka, 2005, Journal of Bone and Mineral Metabolism.

Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis.

T. Kameda, M. Kumegawa, H. Mano, 1996, Biochemical and biophysical research communications.

The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage

M. Kumegawa, K. Shin, Y. Kobayashi, 2003, Journal of Bone and Mineral Metabolism.

Cd38/Adp-Ribosyl Cyclase: A New Role in the Regulation of Osteoclastic Bone Resorption

Li Sun, M. Zaidi, S. Epstein, 1999 .

Cloning and Function of Rabbit Peroxisome Proliferator-activated Receptor δ/β in Mature Osteoclasts*

T. Kameda, M. Kumegawa, Y. Fujisawa, 2000, The Journal of Biological Chemistry.

A simple method to assess osteoclast-mediated bone resorption using unfractionated bone cells.

Y. Takada, H. Kawashima, T. Sato, 1992, Bone and mineral.

Cd38/Adp-Ribosyl Cyclase

Li Sun, M. Zaidi, S. Epstein, 1999, The Journal of cell biology.

Prostaglandin F2α Stimulates Tyrosine Phosphorylation and Mitogen-Activated Protein Kinase in Osteoblastic MC3T3-E1 Cells via Protein Kinase C Activation.

T. Kameda, M. Kumegawa, L. Raisz, 1997, Endocrinology.

Etidronate (EHDP) Inhibits Osteoclastic-Bone Resorption, Promotes Apoptosis and Disrupts Actin Rings in Isolate-Mature Osteoclasts

T. Kameda, M. Kumegawa, J. Shimada, 1999, Calcified Tissue International.

Regulation of Receptor Activator of NF-κB Ligand-induced Osteoclastogenesis by Endogenous Interferon-β (INF-β) and Suppressors of Cytokine Signaling (SOCS)

M. Kumegawa, Y. Toyama, Y. Hakeda, 2002, The Journal of Biological Chemistry.

Osteocytes Produce Interferon-β as a Negative Regulator of Osteoclastogenesis*

Y. Hakeda, Takuya Sato, Yoko Ohyama, 2014, The Journal of Biological Chemistry.

Prostaglandin E2 stimulates DNA synthesis by a cyclic AMP‐independent pathway in osteoblastic clone MC3T3‐E1 cells

N. Kurihara, M. Kumegawa, Y. Hakeda, 1986, Journal of cellular physiology.

Induction of osteoblastic cell differentiation by forskolin. Stimulation of cyclic AMP production and alkaline phosphatase activity.

N. Kurihara, M. Kumegawa, Y. Hakeda, 1985, Biochimica et biophysica acta.

Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues.

R. Kikuno, M. Kumegawa, T. Hashimoto-Gotoh, 1990, Biochemical and biophysical research communications.

Tissue Inhibitor of Metalloproteinases 1 and 2 Directly Stimulate the Bone‐Resorbing Activity of Isolated Mature Osteoclasts

M. Kumegawa, T. Aoki, T. Sobue, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Action of prostaglandins on clonal osteoblastic MC3T3-E1 cells

M. Kumegawa, Y. Hakeda, M. Okawa, 1991, Journal of Bone and Mineral Metabolism.

Prostaglandin E2 Directly Inhibits Bone-Resorbing Activity of Isolated Mature Osteoclasts Mainly Through the EP4 Receptor

M. Kumegawa, T. Yamada, T. Arakawa, 2000, Calcified Tissue International.

Inductive effects of prostaglandins on alkaline phosphatase in osteoblastic cells, clone MC3T3-E1.

N. Kurihara, M. Kumegawa, Y. Hakeda, 1985, Journal of biochemistry.

Effect of chlorpromazine on PZ-peptidase and several other peptidase activities in cloned osteoblastic cells (MC3T3-E1).

N. Kurihara, M. Kumegawa, Y. Ishii, 1987, Biochemical pharmacology.

Effect of 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity and collagen synthesis in osteoblastic cells, clone MC3T3-El1

N. Kurihara, K. Ikeda, M. Kumegawa, 1984 .

Existence of parathyroid hormone binding sites on murine hemopoietic blast cells.

E. Ogata, M. Kumegawa, T. Sato, 1989, Biochemical and biophysical research communications.