Z. Szombathelyi

发表

4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.

J. Galambos, G. Keserű, Z. Szakács, 2016, Bioorganic & medicinal chemistry letters.

Functional characterization of sodium channel blockers by membrane potential measurements in cerebellar neurons: Prediction of compound preference for the open/inactivated state

I. Tarnawa, S. Kolok, J. Nagy, 2006, Neurochemistry International.

Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.

J. Galambos, A. Gere, É. Schmidt, 2012, Bioorganic & medicinal chemistry letters.

Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.

J. Galambos, B. Kiss, L. Molnár, 2010, Bioorganic & medicinal chemistry letters.

Comparative pharmacology of adrenergic α2C receptors coupled to Ca2+ signaling through different Gα proteins

A. Gere, A. Baki, Dalma Kurkó, 2009, Neurochemistry International.

Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.

B. Dalmadi, K. Tihanyi, S. Farkas, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.

B. Kiss, L. Molnár, G. Keserű, 2010, Bioorganic & medicinal chemistry letters.

P.3.c.047 Pharmacokinetics of RGH-188, a new dopamine D3/D2 antagonist/partial agonist atypical antipsychotic, in healthy subjects

I. Laszlovszky, Z. Szombathelyi, M. Borsos, 2007, European Neuropsychopharmacology.

P.3.c.053 Dopamine D2/D3 receptor occupancy of RGH-188, a D3/D2 antagonist/partial agonist antipsychotic, in healthy volunteers

D. Brooks, N. Pavese, I. Laszlovszky, 2007, European Neuropsychopharmacology.

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15

B. Kiss, G. Pásztor, O. Elekes, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Flow cytometry-based method to analyze the change in Tau phosphorylation in a hGSK-3β and hTau over-expressing EcR-293 cell line

M. Sárvári, G. Szendrei, Dalma Kurkó, 2006, Neurochemistry International.

Inducible expression and pharmacological characterization of recombinant rat NR1a/NR2A NMDA receptors

Dalma Kurkó, S. Kolok, Z. Szombathelyi, 2005, Neurochemistry International.

Participation of AMPA- and NMDA-type excitatory amino acid receptors in the spinal reflex transmission, in rat

P. Kocsis, I. Tarnawa, S. Farkas, 2003, Brain Research Bulletin.

NR2B containing NMDA receptor dependent windup of single spinal neurons

P. Kocsis, I. Tarnawa, S. Farkas, 2004, Neuropharmacology.

Neuroprotective Effects of Vinpocetine and its Major Metabolite Cis‐apovincaminic Acid on NMDA‐Induced Neurotoxicity in a Rat Entorhinal Cortex Lesion Model

Csaba Nyakas, K. Felszeghy, C. Nyakas, 2009, CNS neuroscience & therapeutics.

Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones

S. Kolok, J. Nagy, Z. Szombathelyi, 2003, Neurochemistry International.

Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat.

Orsolya Galamb, Béla Molnár, Norbert Solymosi, 2010, Endocrinology.

Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

Eva Schmidt, István Laszlovszky, Béla Kiss, 2010, Journal of Pharmacology and Experimental Therapeutics.

NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones

S. Kolok, S. Farkas, J. Nagy, 2004, Neurochemistry International.

Cariprazine (RGH-188), a D3-preferring dopamine D3/D2 receptor partial agonist antipsychotic candidate demonstrates anti-abuse potential in rats

B. Kiss, V. Román, I. Gyertyán, 2013, Psychopharmacology.

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

B. Kiss, G. Pásztor, K. Tihanyi, 2011, Neurochemistry International.

Effects of RGH-237 [N-{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D3 Receptor Partial Agonist in Animal Models of Cocaine Abuse

B. Kiss, G. Pásztor, K. Tihanyi, 2007, Journal of Pharmacology and Experimental Therapeutics.

Cariprazine (RGH-188), a D3-preferring dopamine D3/D2 receptor partial agonist antipsychotic candidate demonstrates anti-abuse potential in rats

B. Kiss, V. Román, I. Gyertyán, 2012, Psychopharmacology.

Concerted action of antiepileptic and antidepressant agents to depress spinal neurotransmission: Possible use in the therapy of spasticity and chronic pain

K. Tihanyi, B. Farkas, P. Kocsis, 2007, Neurochemistry International.

NR2B receptors are involved in the mediation of spinal segmental reflex potentials but not in the cumulative motoneuronal depolarization in vitro

Gyula Kovács, Csilla Horváth, Pál Kocsis, 2004, Brain Research Bulletin.

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15

É. Schmidt, B. Kiss, I. Laszlovszky, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.

J. Galambos, G. Balogh, G. Keserű, 2017, Journal of medicinal chemistry.

Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.

A. Gere, B. Kiss, A. Nemes, 2008, Journal of medicinal chemistry.

Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.

J. Galambos, B. Kiss, G. Keserű, 2017, European journal of medicinal chemistry.

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

B. Kiss, K. Tihanyi, T. Szabados, 2011, Neurochemistry International.

[Mydeton: a centrally acting muscle relaxant drug from Gedeon Richter LTD].

P. Kocsis, I. Tarnawa, S. Farkas, 2002, Acta pharmaceutica Hungarica.

Comparative pharmacology of adrenergic α2C receptors coupled to Ca2+ signaling through different Gα proteins

A. Gere, A. Baki, Dalma Kurkó, 2009, Neurochemistry International.