K. Sugawara

发表

Effect of clarithromycin on the enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes.

N. Yasui-Furukori, M. Miura, Toshio Suzuki, 2005, Chirality.

Absolute bioavailability and metabolism of omeprazole in relation to CYP2C19 genotypes following single intravenous and oral administrations

M. Hayakari, N. Yasui-Furukori, T. Niioka, 2007, European Journal of Clinical Pharmacology.

The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers

K. Sugimoto, T. Uno, T. Tateishi, 2008, Journal of clinical pharmacy and therapeutics.

Carbamazepine augmentation therapy in three patients with trazodone‐resistant unipolar depression

K. Otani, S. Kaneko, N. Yasui, 1996, International clinical psychopharmacology.

Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam

K. Otani, S. Kaneko, T. Kondo, 2000, Psychopharmacology.

Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site

T. Ishizaki, S. Motomura, T. Uno, 2000, European Journal of Clinical Pharmacology.

The effects of grapefruit juice on the pharmacokinetics of erythromycin

K. Sugawara, T. Ohkubo, S. Kanazawa, 2001, European Journal of Clinical Pharmacology.

Lack of Significant Effect of Grapefruit Juice on the Pharmacokinetics of Lansoprazole and Its Metabolites in Subjects With Different CYP2C19 Genotypes

T. Uno, T. Takahata, T. Tateishi, 2005, Journal of clinical pharmacology.

Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects.

S. Motomura, T. Uno, K. Sugawara, 2006, British journal of clinical pharmacology.

Effect of Carbamazepine on the Single Oral Dose Pharmacokinetics of Alprazolam

K. Otani, S. Kaneko, T. Kondo, 1998, Neuropsychopharmacology.

Estimation of CYP2C19 activity by the omeprazole hydroxylation index at a single point in time after intravenous and oral administration

M. Hayakari, K. Sugimoto, T. Niioka, 2007, European Journal of Clinical Pharmacology.

Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine.

N. Yasui-Furukori, M. Miura, Toshio Suzuki, 2005, British journal of clinical pharmacology.

Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes.

A. Munakata, N. Yasui-Furukori, T. Uno, 2005, British journal of clinical pharmacology.

Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.

Mikiko Shimizu, T. Uno, T. Tateishi, 2006, British journal of clinical pharmacology.

Pharmacokinetics of low-dose nedaplatin and validation of AUC prediction in patients with non-small-cell lung carcinoma

N. Yasui-Furukori, T. Niioka, Mikiko Shimizu, 2007, Cancer Chemotherapy and Pharmacology.

The Role of Cytochrome P2C19 in R-warfarin Pharmacokinetics and its Interaction With Omeprazole

K. Sugimoto, T. Uno, T. Tateishi, 2008, Therapeutic drug monitoring.

Different effects of fluvoxamine on rabeprazole pharmacokinetics in relation to CYP2C19 genotype status.

N. Yasui-Furukori, Mikiko Shimizu, T. Uno, 2006, British journal of clinical pharmacology.

Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography: application to measuring CYP2C19 activity.

N. Yasui-Furukori, T. Uno, T. Takahata, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous Determination of Warfarin Enantiomers and Its Metabolite in Human Plasma by Column-Switching High-Performance Liquid Chromatography With Chiral Separation

M. Hayakari, T. Niioka, T. Uno, 2007, Therapeutic drug monitoring.

Effects of Genetically Determined S–Mephenytoin 4–Hydroxylation Status and Cigarette Smoking on the Single–Dose Pharmacokinetics of Oral Alprazolam

K. Chiba, T. Ishizaki, K. Otani, 1997, Neuropsychopharmacology.

Single-dose pharmacokinetics and pharmacodynamics of oral triazolam in relation to cytochrome P4502C19 (CYP2C19) activity.

K. Chiba, T. Ishizaki, K. Otani, 1997, Therapeutic drug monitoring.

Increases in plasma concentration of m-chlorophenylpiperazine, but not trazodone, with low-dose haloperidol.

K. Otani, A. Suzuki, S. Kaneko, 1997, Therapeutic drug monitoring.

Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.

Mikiko Shimizu, T. Uno, T. Tateishi, 2006, British journal of clinical pharmacology.

Sensitivity of the isolated vas deferens of the guinea-pig to norepinephrine and acetylcholine after denervation, decentralization and treatments by various agents.

K. Sugawara, H. Ozawa, 1970, European journal of pharmacology.

A developed determination of midazolam and 1'-hydroxymidazolam in plasma by liquid chromatography-mass spectrometry: application of human pharmacokinetic study for measurement of CYP3A activity.

H. Kanazawa, Mikiko Shimizu, T. Uno, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

On acute hypotensive effects of pindolol and propranolol in conscious rats

M. Ozaki, K. Sugawara, 1980 .

Lack of Dose-Dependent Effects of Itraconazole on the Pharmacokinetic Interaction with Fexofenadine

Mikiko Shimizu, T. Uno, T. Tateishi, 2006, Drug Metabolism and Disposition.

interaction with fexofenadine

Mikiko Shimizu, T. Uno, K. Sugawara, 2006 .

Therapeutic spectrum of nemonapride and its relationship with plasma concentrations of the drug and prolactin.

K. Otani, S. Kaneko, T. Kondo, 2000, Journal of clinical psychopharmacology.

Correlation between steady-state plasma concentrations of mianserin and trazodone in depressed patients

K. Otani, S. Kaneko, G. Tybring, 1998, European Journal of Clinical Pharmacology.

Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S‐mephenytoin 4′‐hydroxylation phenotype and genotype *

T. Ishizaki, K. Otani, A. Suzuki, 1997, Clinical pharmacology and therapeutics.

Plasma concentrations of trazodonb and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone

K. Otani, S. Kaneko, T. Kondo, 1997, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine.

K. Otani, S. Kaneko, H. Higuchi, 1995, International clinical psychopharmacology.

Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine

S. Tsuchida, F. Gonzalez, K. Otani, 1997, Psychopharmacology.

PHARMACOKINETICS A ND D ISPOSITION

M. Miura, Toshio Suzuki, H. Tada, 2002 .

Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study.

N. Yasui-Furukori, Mikiko Shimizu, T. Uno, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S‐mephenytoin

T. Ishizaki, K. Otani, A. Suzuki, 2001, Clinical pharmacology and therapeutics.

Effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam

M. Miura, K. Otani, Y. Otsuji, 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

No Effect of Itraconazole on the Single Oral Dose Pharmacokinetics and Pharmacodynamics of Estazolam

M. Miura, K. Otani, Y. Otsuji, 2002, Therapeutic drug monitoring.

Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes

M. Miura, H. Tada, T. Uno, 2004, European Journal of Clinical Pharmacology.

Prolactin response to nemonapride, a new antipsychotic drug, in schizophrenic patients

K. Otani, A. Suzuki, S. Kaneko, 1997 .

A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: In vivo evidence for the involvement of CYP3A4 in alprazolam metabolism

T Ishizaki, K Chiba, K. Chiba, 1996, Clinical pharmacology and therapeutics.

Monitoring of phenytoin in human breast milk, maternal plasma and cord blood plasma by solid-phase extraction and liquid chromatography.

Yoshiharu Saito, K. Sugawara, T. Ohkubo, 1998, Journal of pharmaceutical and biomedical analysis.

Monitoring of zonisamide in human breast milk and maternal plasma by solid-phase extraction HPLC method.

K. Sugawara, T. Ohkubo, R. Shimoyama, 1999, Biomedical chromatography : BMC.

Sensitive Determination of Itraconazole and Its Active Metabolite in Human Plasma by Column-switching High-performance Liquid Chromatography With Ultraviolet Detection

Mikiko Shimizu, T. Uno, T. Tateishi, 2006, Therapeutic drug monitoring.

Monitoring of carbamazepine and carbamazepine 10,11-epoxide in breast milk and plasma by high-performance liquid chromatography

K. Sugawara, T. Ohkubo, R. Shimoyama, 2000, Annals of clinical biochemistry.

CHARACTERISTICS OF INTERACTION BETWEEN BARBITURATE DERIVATIVES AND VARIOUS SORBENTS ON LIQUID CHROMATOGRAPHY AND DETERMINATION OF PHENOBARBITAL IN JAPANESEHUMAN BREAST MILK

K. Sugawara, T. Ohkubo, R. Shimoyama, 2000 .

Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography: application to therapeutic drug monitoring in Japanese patients with schizophrenia.

S. Kaneko, N. Yasui, K. Sugawara, 1999, Journal of Pharmaceutical and Biomedical Analysis.

Determination of estazolam in plasma by high-performance liquid chromatography with solid-phase extraction.

M. Miura, K. Otani, K. Sugawara, 2002, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

High‐performance Liquid Chromatographic Determination of Trazodone and 1‐m‐Chlorophenylpiperazine with Ultraviolet and Electrochemical Detector

N. Yasui, K. Sugawara, T. Ohkubo, 1995, The Journal of pharmacy and pharmacology.

Liquid chromatographic determination of manidipine in serum with electrochemical detection.

T. Uno, K. Sugawara, T. Ohkubo, 1996, Journal of chromatography. B, Biomedical applications.

High performance liquid chromatographic determination of levomepromazine in human breast milk and serum using solid phase extraction.

K. Sugawara, T. Ohkubo, R. Shimoyama, 1993, Biomedical chromatography : BMC.

Determination of chlorpromazine in human breast milk and serum by high-performance liquid chromatography.

K. Sugawara, T. Ohkubo, R. Shimoyama, 1993, Journal of chromatography.

Measurement of haloperidol in human breast milk by high-performance liquid chromatography.

K. Sugawara, T. Ohkubo, R. Shimoyama, 1992, Journal of pharmaceutical sciences.

Different Effects of Three Transporting Inhibitors, Verapamil, Cimetidine, and Probenecid, on Fexofenadine Pharmacokinetics

N. Yasui-Furukori, Kazunobu Sugawara, Norio Yasui-Furukori, 2005, Clinical pharmacology and therapeutics.

Liquid chromatographic determination of fexofenadine in human plasma with fluorescence detection.

T. Uno, T. Takahata, T. Tateishi, 2004, Journal of pharmaceutical and biomedical analysis.

Determination of ofloxacin in human serum by high-performance liquid chromatography with column switching.

K. Sugawara, T. Ohkubo, M. Kudo, 1992, Journal of chromatography.

Column-switching high-performance liquid chromatography of ofloxacin in human saliva and correlation of ofloxacin level in saliva and serum.

T. Uno, K. Sugawara, T. Ohkubo, 1996, Therapeutic Drug Monitoring.

Determination of Propylthiouracil in Human Breast Milk by Direct Injection High Performance Liquid Chromatography

T. Uno, K. Sugawara, T. Ohkubo, 1991 .

High-Performance Liquid Chromatographic Determination of Ofloxacin in Serum

K. Sugawara, T. Ohkubo, M. Kudo, 1991 .

Relationship Between Plasma Concentrations of Trazodone and Its Active Metabolite, m-Chlorophenylpiperazine, and Its Clinical Effect in Depressed Patients

K. Otani, S. Kaneko, T. Kondo, 2002, Therapeutic drug monitoring.

Sensitive determination of omeprazole and its two main metabolites in human plasma by column-switching high-performance liquid chromatography: application to pharmacokinetic study in relation to CYP2C19 genotypes.

T. Niioka, Mikiko Shimizu, T. Uno, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The determination of ofloxacin in human skin tissue by high‐performance liquid chromatography and correlation between skin tissue concentration and serum level of ofloxacin

K. Sugawara, T. Ohkubo, M. Kudo, 1994, The Journal of pharmacy and pharmacology.

[Development of measurement of new quinolones in body fluids by HPLC using column switching and their application to drug interaction].

K. Sugawara, T. Ohkubo, M. Kudo, 2001, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

No correlations between the urinary ratio of 6β-hydroxycortisol to free cortisol and pharmacokinetics of alprazolam

K. Chiba, K. Otani, S. Kaneko, 2001, European Journal of Clinical Pharmacology.

Determination of Fleroxacin in Plasma by Direct Injection High Performance Liquid Chromatography with Column Switching

K. Sugawara, T. Ohkubo, M. Kudo, 1999 .

Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder

K. Itoh, Toshio Suzuki, K. Otani, 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Sites of action of crystalline tetrodotoxin on sympathetic nervous systems.

K. Sugawara, H. Ozawa, 1967, Japanese journal of pharmacology.

Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes

Mikiko Shimizu, T. Uno, T. Tateishi, 2006, European Journal of Clinical Pharmacology.

High-performance liquid chromatographic determination of nifedipine and a trace photodegradation product in hospital prescriptions.

K. Sugawara, T. Ohkubo, H. Noro, 1992, Journal of pharmaceutical and biomedical analysis.

Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients

K. Otani, S. Kaneko, N. Yasui, 1997, International clinical psychopharmacology.

Potentiating effect of lithium chloride on aggressive behavior induced in mice by nialamide plus L-DOPA and by clonidine.

K. Sugawara, T. Miyauchi, H. Ozawa, 1975, European journal of pharmacology.

Association between -1438G/A Promoter Polymorphism in the 5-HT2A Receptor Gene and Fluvoxamine Response in Japanese Patients with Major Depressive Disorder

Tetsuo Shimizu, Kunihiko Itoh, Hisashi Higuchi, 2002, Neuropsychobiology.

Effects of Fluvoxamine on Lansoprazole Pharmacokinetics in Relation to CYP2C19 Genotypes

T. Uno, T. Takahata, T. Tateishi, 2004, Journal of clinical pharmacology.

Identification of a Single Time-point for Plasma Lansoprazole Measurement That Adequately Reflects Area Under the Concentration-Time Curve

T. Niioka, S. Kaneko, T. Uno, 2006, Therapeutic drug monitoring.

Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates.

T. Uno, T. Takahata, T. Tateishi, 2004, Basic & clinical pharmacology & toxicology.

Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine.

K. Otani, S. Kaneko, K. Sugawara, 1996, Therapeutic drug monitoring.

β-Adrenoceptor blocking agents release catecholamines from rat adrenal medulla

M. Niwa, M. Ozaki, K. Sugawara, 1980 .

Relationship between single oral dose pharmacokinetics of alprazolam and triazolam

K. Otani, S. Kaneko, H. Tasaki, 1997, International clinical psychopharmacology.

Pharmacological analysis of acetylcholine-induced contraction in mouse vas deferens.

K. Sugawara, F. Abe, H. Ozawa, 1974, Japanese journal of pharmacology.

Hypotensive actions of several beta-adrenoceptor blocking agents in conscious normotensive rats.

M. Ozaki, K. Sugawara, N. Takami, 1979, Japanese journal of pharmacology.

Hypotensive action of OPC-1427, a new beta-adrenergic blocking agent in rats.

M. Ozaki, K. Sugawara, N. Takami, 1979, Archives internationales de pharmacodynamie et de therapie.

Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients

K. Itoh, Toshio Suzuki, K. Otani, 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Inhibition of Trazodone Metabolism by Thioridazine in Humans

K. Otani, S. Kaneko, T. Kondo, 1995, Therapeutic drug monitoring.

Enantiomer separation of dihydropyridine derivatives by liquid chromatography with chiral stationary phase

T. Uno, K. Sugawara, T. Ohkubo, 1992 .

Effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolam

K. Otani, S. Kaneko, Tadashi Ohkubo, 1998, Psychopharmacology.

Graphic roots of CYP2C19 genetic polymorphism in Japanese population (preliminary report)

S. Motomura, K. Sugawara, T. Ohkubo, 2002 .

Structure-activity relationship of alkylguanidines on smooth muscle organs.

K. Sugawara, H. Ozawa, 1968, Chemical and pharmaceutical bulletin.

No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment

Kunihiko Ito, Toshio Suzuki, H. Higuchi, 2002, European Neuropsychopharmacology.

Relation between Kidney Function and Use Trend of Renal Excreted Agents on Inpatients of Digestive Organ Surgery in Hirosaki University Hospital.

T. Morita, M. Sasaki, T. Niioka, 2001 .

Concentration of orally administered antimicrobial agent in burn scar tissue, granulation tissue, normal skin and serum.

K. Sugawara, T. Ohkubo, M. Kudo, 1993, Burns : journal of the International Society for Burn Injuries.

An evaluation of a new lactic acid polymer drug delivery system: a preliminary report.

K. Otani, K. Sugawara, T. Ohkubo, 1994, British Journal of Plastic Surgery.

Enantioselective high-performance liquid chromatographic determination of nicardipine in human plasma.

T. Uno, K. Sugawara, T. Ohkubo, 1997, Journal of chromatography. B, Biomedical sciences and applications.

ENANTIOSELECTIVE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF MANIDIPINE IN HUMAN PLASMA

T. Uno, K. Sugawara, T. Ohkubo, 1999 .

Prolactin response to nemonapride, a new antipsychotic drug, in schizophrenic patients

K. Otani, A. Suzuki, S. Kaneko, 1997 .

Identification of the time-point which gives a plasma rabeprazole concentration that adequately reflects the area under the concentration-time curve

T. Niioka, Mikiko Shimizu, T. Uno, 2006, European Journal of Clinical Pharmacology.

Synthesis and cataleptic effects of optically active dihydrohaloperidols and dihydrobromoperidols.

T. Araki, Y. Oshima, Y. Takeshita, 1997, Chirality.