V. Gorboulev

发表

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.

U. Brinkmann, M. Eichelbaum, H. Koepsell, 2002, Pharmacogenetics.

RS 1 ( RSC 1 A 1 ) regulates the exocytotic pathway of Na-D-glucose cotransporter SGLT 1

H. Koepsell, T. Keller, V. Gorboulev, 2006 .

RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1.

H. Koepsell, T. Keller, V. Gorboulev, 2006, American journal of physiology. Renal physiology.

differences and androgen-dependent gender Rat renal glucose transporter SGLT1 exhibits zonal

H. Koepsell, Mario Skarica, I. Sabolić, 2006 .

Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences.

H. Koepsell, Mario Skarica, I. Sabolić, 2006, American journal of physiology. Renal physiology.

Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

H. Parker, F. Reimann, F. Gribble, 2011, Diabetes.

Regulation of the human organic cation transporter hOCT1

H. Koepsell, E. Schlatter, J. Hirsch, 2004, Journal of cellular physiology.

Molecular Pharmacology of Organic Cation Transporters in Kidney

H. Koepsell, V. Gorboulev, P. Arndt, 1999, The Journal of Membrane Biology.

Membrane localization of the electrogenic cation transporter rOCT1 in rat liver.

H. Koepsell, F. Meyer-Wentrup, U. Karbach, 1998, Biochemical and biophysical research communications.

Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.

E. Bamberg, G. Nagel, H. Koepsell, 2001, American journal of physiology. Renal physiology.

The Cation Transporters rOCT1 and rOCT2 Interact with Bicarbonate but Play Only a Minor Role for Amantadine Uptake into Rat Renal Proximal Tubules

H. Koepsell, G. Lou, D. Sitar, 2002, Journal of Pharmacology and Experimental Therapeutics.

The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation.

H. Koepsell, E. Schlatter, H. Hohage, 2000, Journal of the American Society of Nephrology : JASN.

Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1

F. Lang, H. Koepsell, S. Waldegger, 1996, FEBS letters.

Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase

H. Koepsell, T. Mueller, J. Groll, 2016, Molecular Pharmacology.

Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases.

H. Koepsell, A. Velic, E. Schlatter, 2003, American journal of physiology. Renal physiology.

Downregulation of the Na+-D-glucose Cotransporter SGLT1 by Protein RS1 (RSC1A1) is Dependent on Dynamin and Protein Kinase C

F. Lang, H. Koepsell, C. Wagner, 2003, The Journal of Membrane Biology.

A glucose sensor hiding in a family of transporters

E. Wright, B. Hirayama, H. Koepsell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Response to Comment on: Gorboulev et al. Na+-d-glucose Cotransporter SGLT1 Is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion. Diabetes 2012;61:187–196

H. Koepsell, V. Gorboulev, 2012, Diabetes.

Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

H. Parker, F. Reimann, F. Gribble, 2011, Diabetes.

Na(+)-D-glucose cotransporter in muscle capillaries increases glucose permeability.

H. Koepsell, B. Kaissling, A. Deussen, 2004, Biochemical and biophysical research communications.

Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1.

H. Koepsell, M. Wiessler, V. Gorboulev, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Purification and functional reconstitution of the rat organic cation transporter OCT1.

H. Koepsell, H. Reiländer, T. Keller, 2005, Biochemistry.

The Plasma Membrane-associated Protein RS1 Decreases Transcription of the Transporter SGLT1 in Confluent LLC-PK1 Cells*

H. Koepsell, T. Korn, V. Gorboulev, 2001, The Journal of Biological Chemistry.

by PKA, PI3K, and calmodulin-dependent kinases Regulation of human organic cation transporter hOCT2

H. Koepsell, E. Schlatter, J. Hirsch, 2016 .

Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.

H. Koepsell, T. Keller, G. Ciarimboli, 2007, American journal of physiology. Renal physiology.

Identiﬁcation of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate afﬁnity

H. Koepsell, T. Keller, G. Ciarimboli, 2007 .

Characterization of regulatory mechanisms and states of human organic cation transporter 2.

H. Koepsell, A. Zvirbliene, H. Pavenstädt, 2006, American journal of physiology. Cell physiology.

Proximal Tubular Transport of Organic Compounds Polyspecific cation transporters in the proximal tubule

H. Koepsell, U. Karbach, V. Gorboulev, 2000 .

The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.

M. Schmid, H. Koepsell, B. Wissinger, 1997, Cytogenetics and cell genetics.

Transport of Lamivudine ( 3 TC ) and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors With Human Organic Cation Transporters 1 , 2 , and 3

G. Minuesa, V. Gorboulev, I. Erkizia, 2009 .

Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine.

H. Koepsell, E. Wischmeyer, T. Müller, 2009, American journal of physiology. Renal physiology.

High-affinity Cation Binding to Transporter OCT 1 Induces Movement of Helix 11 and Blocks Transport after Mutations in a Modelled Interaction Domain between Two Helices

E. Bamberg, T. Friedrich, H. Koepsell, 2007 .

Cell free expression and functional reconstitution of eukaryotic drug transporters.

V. Dötsch, H. Koepsell, C. Hunte, 2008, Biochemistry.

Organic cation transporters.

H. Koepsell, V. Gorboulev, B. Schmitt, 2003, Reviews of physiology, biochemistry and pharmacology.

Cloning and characterization of two human polyspecific organic cation transporters.

F. Lang, H. Koepsell, A. Busch, 1997, DNA and cell biology.

Organic cation transporter capable of transporting serotonin is up‐regulated in serotonin transporter‐deficient mice

K. Lesch, D. Murphy, H. Koepsell, 2003, Journal of neuroscience research.

Transport of Lamivudine [(-)-β-l-2′,3′-Dideoxy-3′-thiacytidine] and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors with Human Organic Cation Transporters 1, 2, and 3

B. Clotet, J. Martinez-Picado, H. Koepsell, 2009, Journal of Pharmacology and Experimental Therapeutics.

Localization of organic cation transporters OCT1 and OCT2 in rat kidney.

H. Koepsell, S. Bachmann, B. Kaissling, 2000, American journal of physiology. Renal physiology.

Drug excretion mediated by a new prototype of polyspecific transporter

H. Koepsell, S. Gambaryan, D. Gründemann, 1994, Nature.

Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer

V. Dötsch, H. Koepsell, T. Mueller, 2018, Molecular Pharmacology.

The Large Extracellular Loop of Organic Cation Transporter 1 Influences Substrate Affinity and Is Pivotal for Oligomerization*

H. Sitte, V. Dötsch, H. Koepsell, 2011, The Journal of Biological Chemistry.

Mice without the Regulator Gene Rsc1A1 Exhibit Increased Na+-d-Glucose Cotransport in Small Intestine and Develop Obesity

K. Knobeloch, H. Koepsell, H. Joost, 2005, Molecular and Cellular Biology.

Structure and Function of Renal Organic Cation Transporters.

H. Koepsell, A. Busch, V. Gorboulev, 1998, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

Electrogenic Properties and Substrate Specificity of the Polyspecific Rat Cation Transporter rOCT1*

F. Lang, H. Koepsell, S. Waldegger, 1996, The Journal of Biological Chemistry.

Transportersand Function of Renal Organic Cation

A. Busch, V. Gorboulev, P. Arndt, 2016 .

Roct1, a rat polyspecific transporter gene for the excretion of cationic drugs, maps to Chromosome 1q11-12

C. Steinlein, M. Schmid, H. Koepsell, 1996, Mammalian Genome.

Erratum to the report of the third international workshop on human Y chromosome mapping 1997

A. Uitterlinden, E. Mullaart, A. Protopopov, 1997 .

Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.

F. Lang, H. Koepsell, S. Waldegger, 1998, Molecular pharmacology.

Novel Shuttling Domain in a Regulator (RSC1A1) of Transporter SGLT1 Steers Cell Cycle‐Dependent Nuclear Location

H. Koepsell, S. Hübner, Y. Reinders, 2009, Traffic.

Tripeptides of RS1 (RSC1A1) Inhibit a Monosaccharide-dependent Exocytotic Pathway of Na+-d-Glucose Cotransporter SGLT1 with High Affinity*

G. Burckhardt, H. Koepsell, R. Pipkorn, 2007, Journal of Biological Chemistry.

OCT-3, Organic Cation Transporter 3

H. Koepsell, V. Gorboulev, 2008 .

Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2.

G. Nagel, H. Koepsell, V. Gorboulev, 2003, Molecular pharmacology.

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA‐methyltransferase inhibitors

J. Martinez-Picado, H. Koepsell, M. Pastor-Anglada, 2014, British journal of pharmacology.

Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake

H. Koepsell, T. Mueller, M. Tzvetkov, 2018, Molecular Pharmacology.

Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.

H. Koepsell, F. Thévenod, T. Keller, 2013, Molecular pharmaceutics.

A Substrate Binding Hinge Domain Is Critical for Transport-related Structural Changes of Organic Cation Transporter 1*

H. Koepsell, T. Mueller, T. Keller, 2012, The Journal of Biological Chemistry.

Five Amino Acids in the Innermost Cavity of the Substrate Binding Cleft of Organic Cation Transporter 1 Interact with Extracellular and Intracellular Corticosterone

H. Koepsell, A. Kotzsch, V. Gorboulev, 2009, Molecular Pharmacology.

High-Affinity Cation Binding to Organic Cation Transporter 1 Induces Movement of Helix 11 and Blocks Transport after Mutations in a Modeled Interaction Domain between Two Helices

E. Bamberg, T. Friedrich, H. Koepsell, 2008, Molecular Pharmacology.

Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation.

H. Koepsell, E. Schlatter, B. Edemir, 2005, Journal of the American Society of Nephrology : JASN.

Subtype-Specific Affinity for Corticosterone of Rat Organic Cation Transporters rOCT1 and rOCT2 Depends on Three Amino Acids within the Substrate Binding Region

H. Koepsell, V. Gorboulev, C. Volk, 2005, Molecular Pharmacology.

Amino Acids Critical for Substrate Affinity of Rat Organic Cation Transporter 1 Line the Substrate Binding Region in a Model Derived from the Tertiary Structure of Lactose Permease

H. Koepsell, Dmitry Gorbunov, V. Gorboulev, 2005, Molecular Pharmacology.

Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate.

H. Koepsell, V. Gorboulev, C. Volk, 1999, Molecular pharmacology.

Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption

H. Koepsell, R. Pipkorn, J. Groll, 2016, Molecular Pharmacology.

Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus.

H. Koepsell, M. Kroiss, V. Gorboulev, 2006, American journal of physiology. Renal physiology.

Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis.

S. Kuerten, A. Rottlaender, V. Gorboulev, 2015, Clinical immunology.

OCT-1, Organic Cation Transporter 1

H. Koepsell, V. Gorboulev, 2008 .

OCT-2, Organic Cation Transporter 2

H. Koepsell, V. Gorboulev, 2008 .

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA‐methyltransferase inhibitors

J. Martinez-Picado, H. Koepsell, M. Pastor-Anglada, 2014, British journal of pharmacology.

Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis.

S. Kuerten, A. Rottlaender, V. Gorboulev, 2015, Clinical immunology.