Divesh Aidasani

Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme

D. Rock, R. Subramanian, G. Tonn, 2012, Drug Metabolism and Disposition.

Substrate redox potential controls superoxide production kinetics in the cytochrome bc complex.

M. Bowman, D. Kramer, Jonathan Cape, 2009, Biochemistry.

Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Daniel J. Freeman, J. McCarter, Nancy Zhang, 2012, Journal of medicinal chemistry.

Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione.

R. Subramanian, G. Skiles, D. Reid, 2011, Chemical research in toxicology.

In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition

C. Locuson, Divesh Aidasani, M. J. Zaya, 2008, Drug Metabolism and Disposition.

P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors.

D. Branstetter, H. Lebrec, R. Subramanian, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition

C. Locuson, Divesh Aidasani, M. J. Zaya, 2008, Drug Metabolism and Disposition.