D. James

发表

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Callen T. Wallace, Simon C Watkins, A. Nesvizhskii, 2020, Nature Structural & Molecular Biology.

M. Priault, J. Martinou, S. Nothwehr, 2003, Essays in biochemistry.

IncucyteDRC: An R package for the dose response analysis of live cell imaging data

Philip J. Chapman, A. Watson, D. Ogilvie, 2016, F1000Research.

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib

H. Bryant, Amit Nathubhai, Kate M Smith, 2018, DNA repair.

Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase

H. Bryant, Kate M Smith, P. Gravells, 2017, DNA repair.

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells

M. O’Connor, D. Ogilvie, I. Waddell, 2016, F1000Research.

A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase.

D. Ogilvie, I. Waddell, D. James, 2016, Analytical biochemistry.

An HTS-compatible HTRF assay measuring the glycohydrolase activity of human PARG

Caroline, D. Ogilvie, I. Waddell, 2016 .

Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.

A. Jordan, James R. Hitchin, D. Ogilvie, 2012, Journal of medicinal chemistry.

Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells

C. Chresta, S. Guichard, P. Sini, 2010, Autophagy.

Mitochondrial dynamics and apoptosis: a painful separation.

J. Martinou, D. James, 2008, Developmental cell.

157 The mTOR kinase inhibitor AZD8055 induces cell death in Her2+ tumours partially or intrinsically resistant to ErbB2 inhibitors

J. Dry, S. Guichard, A. Logié, 2010 .

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Lisa L. Smith, C. Chresta, S. Guichard, 2010, Cancer research.

Quality Control Parameters for Mitochondria Transplant in Cardiac Tissue

S. Levitsky, J. Preble, D. James, 2014 .

Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis

J. Martinou, O. Donzé, Yves Mattenberger, 2006, Molecular and Cellular Biology.

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.

Bohdan Waszkowycz, Allan M Jordan, J. Tucker, 2016, ACS chemical biology.

Mitochondrial bioenergetics and structural network organization

T. Letellier, R. Rossignol, N. Bellance, 2007, Journal of Cell Science.

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

J. Martinou, Yves Mattenberger, S. Da Cruz, 2008, PloS one.

Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells

I. Agoulnik, D. Ogilvie, I. Waddell, 2020, Scientific Reports.

hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery*

J. Martinou, Yves Mattenberger, D. James, 2003, Journal of Biological Chemistry.

Mitochondria: regulating the inevitable.

J. Martinou, D. James, P. Parone, 2002, Biochimie.

The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis.

L. Scorrano, J. Martinou, L. Vergani, 2006, Molecular biology of the cell.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

M. Lopes, L. Wessels, J. Bartek, 2018, Cancer cell.

The Development of an Immunohistochemical Method to Detect the Autophagy-Associated Protein LC3-II in Human Tumor Xenografts

R. Wilkinson, B. Wyspiańska, J. Foster, 2011, Toxicologic pathology.

Role of mitochondrial membrane permeabilization in apoptosis and cancer

J. Martinou, C. Dive, D. James, 2004, Oncogene.

Ca2+ Homeostasis during Mitochondrial Fragmentation and Perinuclear Clustering Induced by hFis1*[boxs]

J. Martinou, A. Danckaert, N. Demaurex, 2004, Journal of Biological Chemistry.

Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin

J. Martinou, Yves Mattenberger, D. James, 2003, FEBS letters.

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

Stephen S. Taylor, D. Spierings, D. Jackson, 2019, Cancer cell.

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

J. Tucker, B. Waszkowycz, A. Jordan, 2018, Journal of medicinal chemistry.

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.

M. O’Connor, D. Ogilvie, I. Waddell, 2016, F1000Research.

Poly (ADP) ribose glycohydrolase can be effectively targeted in pancreatic cancer.

C. Yeo, M. Pishvaian, K. Olive, 2019, Cancer research.

Abstract C39: First-in-class inhibitors of the putatively undruggable DNA repair target Poly(ADP-ribose) glycohydrolase (PARG)

B. Waszkowycz, A. Jordan, D. Ogilvie, 2015 .

Abstract 2745: Pharmacological characterisation of cell active inhibitors of Poly(ADP-ribose) glycohydrolase (PARG)

B. Waszkowycz, A. Jordan, D. Ogilvie, 2014 .

Abstract 1943: PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition

Kedar S Vaidya, M. P. Dillon, M. Fischer, 2018, Experimental and Molecular Therapeutics.

Studying Catabolism of Protein ADP-Ribosylation.

I. Ahel, L. Palazzo, I. Waddell, 2017, Methods in molecular biology.

Mechanisms of mitochondrial outer membrane permeabilization.

J. Martinou, S. Montessuit, D. James, 2007, Novartis Foundation symposium.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

M. Lopes, L. Wessels, J. Bartek, 2019, Cancer cell.

Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells

I. Agoulnik, D. Ogilvie, I. Waddell, 2020, Scientific Reports.

Mitochondrial dynamics and apoptosis: a painful separation.

J. Martinou, D. James, 2008, Developmental cell.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

M. Lopes, L. Wessels, J. Bartek, 2018, Cancer cell.