J. Kühnl

发表

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model.

U. Müller-Vieira, U. Marx, N. Hewitt, 2020, Toxicology.

Human Peripheral Blood Monocyte Derived Dendritic Cells Assay for the Detection and Characterization of Sensitizers

A. Schepky, P. Aeby, J. Kühnl, 2017 .

Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data.

S. Hoffmann, E. van Vliet, N. Alépée, 2022, Regulatory toxicology and pharmacology : RTP.

Skin Doctor CP: Conformal Prediction of the Skin Sensitization Potential of Small Organic Molecules

U. Norinder, J. Kirchmair, Christina de Bruyn Kops, 2020, Chemical research in toxicology.

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients.

Martina Klaric, Sebastian Hoffmann, Petra S Kern, 2020, Regulatory toxicology and pharmacology : RTP.

Genomic allergen rapid detection in-house validation--a proof of concept.

Andreas Schepky, Malin Lindstedt, Jochen Kühnl, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Computational approaches for skin sensitization prediction

Johannes Kirchmair, Jochen Kühnl, Anke Wilm, 2018, Critical reviews in toxicology.

Oxytocin modulates proliferation and stress responses of human skin cells: implications for atopic dermatitis

A. Bürkle, H. Wenck, G. Neufang, 2013, Experimental dermatology.

Licochalcone A activates Nrf2 in vitro and contributes to licorice extract‐induced lowered cutaneous oxidative stress in vivo

Sandra A. Gehrke, H. Wenck, L. Kolbe, 2015, Experimental dermatology.

SWAP-70 associates transiently with macropinosomes.

S. Grabbe, M. Bähler, S. Balkow, 2007, European journal of cell biology.

Non-animal methods to predict skin sensitization (II): an assessment of defined approaches**

Bertrand Desprez, Martina Klaric, David Allen, 2018, Critical reviews in toxicology.

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database*

Bertrand Desprez, Martina Klaric, David Allen, 2018, Critical reviews in toxicology.

Predicting the Skin Sensitization Potential of Small Molecules with Machine Learning Models Trained on Biologically Meaningful Descriptors

U. Norinder, J. Kirchmair, Steffen Hirte, 2021, Pharmaceuticals.

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

N. Hewitt, I. Maschmeyer, A. Najjar, 2023, Frontiers in Pharmacology.

Functional analysis of the methylmalonyl‐CoA epimerase from Caenorhabditis elegans

E. Liebau, K. Lüersen, R. D. Walter, 2005, The FEBS journal.

alpha-Glucosylrutin plus Licochalcone A: Enhanced protective efficacy in PLE

L. Kolbe, G. Neufang, J. Kühnl, 2011 .

Role of fibroblasts in the pathogenesis of atopic dermatitis.

Horst Wenck, Jochen Kühnl, Thomas Schwarz, 2013, The Journal of allergy and clinical immunology.

Skin Doctor: Machine Learning Models for Skin Sensitization Prediction that Provide Estimates and Indicators of Prediction Reliability

Andreas Schepky, Johannes Kirchmair, Jochen Kühnl, 2019, International journal of molecular sciences.

Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model

U. Marx, N. Hewitt, I. Maschmeyer, 2021, Journal of applied toxicology : JAT.

State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop.

L. Gribaldo, M. Pallardy, D. Naisbitt, 2018, ALTEX.

Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein.

I. Maschmeyer, A. Schepky, J. Kühnl, 2023, Journal of Applied Toxicology.

Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first‐pass skin metabolism of the hair dye, 4‐amino‐2‐hydroxytoluene

I. Maschmeyer, A. Schepky, J. Kühnl, 2023, Journal of applied toxicology : JAT.

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

A. Najjar, A. Schepky, D. Lange, 2024, Frontiers in pharmacology.