M. Fábry

发表

Engineering enzyme subsite specificity: preparation, kinetic characterization, and X-ray analysis at 2.0-A resolution of Val111Phe site-mutated calf chymosin.

V. Kostka, P. Štrop, J. Pohl, 1990, Biochemistry.

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

V. Veverka, M. Hubálek, K. Cermakova, 2018, Proceedings of the National Academy of Sciences.

Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues.

R. Cummings, J. Brynda, K. Smetana, 2006, International journal of molecular medicine.

Lenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells

V. Král, M. Trněný, P. Klener, 2015, Oncoimmunology.

Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds

V. Král, J. Brynda, M. Hajdúch, 2021, Chembiochem : a European journal of chemical biology.

Carborane-based carbonic anhydrase inhibitors.

P. Mader, J. Brynda, P. Cígler, 2013, Angewandte Chemie.

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.

A. Brzozowski, J. Radosavljević, M. Fábry, 2018, Biochemistry.

Nanodiamonds as traps for fibroblast growth factors: Parameters influencing the interaction

V. Veverka, P. Cígler, Daria Miliaieva, 2022, Carbon.

Crystallization of the Effector-Binding Domain of Repressor DeoR from Bacillus subtilis

K. Procházková, P. Řezáčová, M. Fábry, 2013 .

Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors.

M. Federwisch, H. Reinauer, M. Wichert, 2001, The Biochemical journal.

Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells.

V. Král, T. Etrych, S. Filippov, 2018, Biomacromolecules.

Coiled coil peptides as universal linkers for the attachment of recombinant proteins to polymer therapeutics.

K. Ulbrich, V. Král, O. Vaněk, 2011, Biomacromolecules.

Fermentation conditions for high‐level expression of the tac‐promoter‐controlled calf prochymosin cDNA in Escherichia coli HB101

J. Sedláček, M. Fábry, P. Ječmen, 1991, Biotechnology and bioengineering.

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex.

J. Konvalinka, J. Brynda, P. Řezáčová, 2004, Acta crystallographica. Section D, Biological crystallography.

Recombinant fragment of an antibody tailored for direct radioiodination

V. Král, R. Mikołajczak, P. Řezáčová, 2012 .

Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases.

S. Williams, Steven R. Williams, D. Martin, 1985, The Journal of biological chemistry.

A new approach to CAR T-cell gene engineering and cultivation using piggyBac transposon in the presence of IL-4, IL-7 and IL-21.

V. Král, P. Lesný, Š. Němečková, 2018, Cytotherapy.

Avidin-conjugated polymers with monobiotinylated antibody fragments: A new strategy for the noncovalent attachment of recombinant proteins for polymer therapeutics

K. Ulbrich, V. Král, M. Pechar, 2013 .

Conformationally constrained nucleoside phosphonic acids--potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases.

J. Brynda, V. Veverka, P. Řezáčová, 2014, Organic & biomolecular chemistry.

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85.

V. Král, D. Svergun, Zdeněk Tošner, 2015, Journal of structural biology.

Base pairing mRNA-rRNA. The arrangement of nucleotides in the message for coat protein of phage MS 2.

A. Vítek, D. Volný, J. Sedláček, 1978, Acta virologica.

A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease.

J. Hašek, J. Konvalinka, J. Dušková, 2001, Acta crystallographica. Section D, Biological crystallography.

Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX.

V. Král, J. Brynda, P. Řezáčová, 2020, ChemPlusChem.

Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.

M. Havranek, V. Král, J. Brynda, 2020, European journal of medicinal chemistry.

A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution.

Milan Soucek, J. Konvalinka, J. Brynda, 2004, Journal of medicinal chemistry.

Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

Zdeněk Tošner, J. Brynda, V. Veverka, 2014, Biomolecular NMR assignments.

Backbone resonance assignments of human cytosolic dNT-1 nucleotidase

Zdeněk Tošner, J. Brynda, V. Veverka, 2013, Biomolecular NMR Assignments.

Thiopurine intolerance-causing mutations in NUDT15 induce temperature-dependent destabilization of the catalytic site.

D. Kavan, P. Man, P. Novák, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide.

J. Lescar, J. Brynda, P. Řezáčová, 2005, Journal of structural biology.

An improved double stranded DNA sequencing method using gene 32 protein.

P. Kašpar, M. Fábry, S. Zadražil, 1989, Nucleic acids research.

Tumor Marker B7-H6 Bound to the Coiled Coil Peptide-Polymer Conjugate Enables Targeted Therapy by Activating Human Natural Killer Cells

V. Král, O. Vaněk, J. Blaha, 2021, Biomedicines.

Processing, purification, and kinetic characterization of the Gag-Pol encoded retroviral proteinase of myeloblastosis associated virus expressed in E. coli.

J. Brynda, J. Sedláček, M. Fábry, 1995, Advances in experimental medicine and biology.

High‐level expression of enzymatically active bovine leukemia virus proteinase in E. coli

J. Konvalinka, P. Štrop, M. Andreánsky, 1991, FEBS letters.

Effects of temperature and novobiocin on the expression of calf prochymosin gene and on plasmid copy number in recombinantEscherichia coli

J. Sedláček, M. Fábry, P. Tichý, 2008, Folia Microbiologica.

Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X‐ray crystallography, microcalorimetry, and molecular dynamics simulations

V. Král, P. Mader, J. Brynda, 2007, Proteins.

A ubiquitous disordered protein interaction module orchestrates transcription elongation

Eric A. Smith, K. Adelman, V. Veverka, 2021, Science.

An Approach to Controlled Removal of the 3′ End of Ribosomal 16S RNA

J. Sedláček, M. Fábry, E. Holoda, 1985 .

Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody.

J. Lescar, J. Brynda, P. Řezáčová, 2001, Structure.

Inhibition of the HIV‐1 and HIV‐2 proteases by a monoclonal antibody

J. Lescar, J. Brynda, P. Řezáčová, 1999, Protein science : a publication of the Protein Society.

Three-dimensional structure of an Fab-peptide complex: structural basis of HIV-1 protease inhibition by a monoclonal antibody.

J. Lescar, J. Brynda, G. Bentley, 1997, Journal of molecular biology.

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

V. Veverka, P. Man, P. Řezáčová, 2016, BMC Biology.

N-Glycosylation can selectively block or foster different receptor–ligand binding modes

I. Vattulainen, V. Veverka, P. Řezáčová, 2021, Scientific Reports.

N-glycosylation blocks and simultaneously fosters different receptor-ligand binding sites: the chameleonic CD44–hyaluronan interaction

I. Vattulainen, V. Veverka, P. Řezáčová, 2020, bioRxiv.

Peptidomimetic inhibitors complexed with HIV-1 protease: crystallisation for X-ray diffraction studies.

J. Hašek, J. Konvalinka, J. Dohnálek, 1998, General physiology and biophysics.

Molecular Mechanism of LEDGF/p75 Dimerization.

J. Brynda, V. Veverka, K. Cermakova, 2020, Structure.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

V. Veverka, K. Cermakova, K. Procházková, 2015, Nature Communications.

Expression of Prochymosin cDNA in E.Coli

J. Sedláček, M. Fábry, F. Kaprálek, 1988 .

Metallacarborane sulfamides: unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX.

V. Král, J. Brynda, P. Džubák, 2019, Journal of medicinal chemistry.

Kinetic and structural characterization of an alternatively spliced variant of human mitochondrial 5′(3′)-deoxyribonucleotidase

J. Brynda, V. Veverka, P. Řezáčová, 2015, Journal of Enzyme Inhibition and Medicinal Chemistry.

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.

V. Veverka, J. Trka, D. Ascher, 2018 .

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation

David B. Ascher, Petr Novák, William L. Carroll, 2018, Leukemia.

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

I. Pichová, J. Brynda, P. Řezáčová, 2023, Journal of medicinal chemistry.

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

P. Hobza, J. Radosavljević, M. Lepšík, 2019, The Journal of Biological Chemistry.

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain*

Zdeněk Tošner, V. Veverka, P. Srb, 2016, The Journal of Biological Chemistry.

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

V. Veverka, P. Man, P. Řezáčová, 2016, BMC Biology.

Optimization of the crystallizability of a single-chain antibody fragment.

V. Král, V. Veverka, P. Řezáčová, 2014, Acta crystallographica. Section F, Structural biology communications.

Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies.

V. Král, J. Konvalinka, J. Brynda, 2008, Antiviral research.

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX

M. Havranek, V. Král, J. Brynda, 2020, Journal of enzyme inhibition and medicinal chemistry.

Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors.

J. Brynda, P. Řezáčová, I. Rosenberg, 2014, Acta crystallographica. Section D, Biological crystallography.

Structure-based design of a bisphosphonate 5′(3′)-deoxyribonucleotidase inhibitor

J. Brynda, P. Řezáčová, M. Buděšínský, 2015 .

Expression and properties of prochymosin derivatives containing extensions of various length in the pro-part.

J. Sedláček, P. Kašpar, M. Fábry, 1988, Gene.

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases.

J. Lescar, J. Brynda, P. Řezáčová, 2003, Acta crystallographica. Section D, Biological crystallography.

Inhibition of HIV protease by monoclonal antibodies

J. Lescar, J. Brynda, P. Řezáčová, 2002, Journal of molecular recognition : JMR.

Anti-HIV proteinase monoclonal antibody F11.2.32 that inhibits enzyme activity.

J. Lescar, J. Brynda, P. Řezáčová, 1998, General physiology and biophysics.

Structural studies of HIV-1 protease-inhibiting antibodies.

J. Lescar, J. Brynda, G. Bentley, 1998, General physiology and biophysics.

Preliminary crystallographic studies of an anti‐HIV‐1 protease antibody that inhibits enzyme activity

J. Lescar, J. Brynda, G. Bentley, 1996, Protein science : a publication of the Protein Society.

Structure of the effector‐binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis

Z. Otwinowski, M. Hubálek, P. Řezáčová, 2014, The FEBS journal.

Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.

K. Ulbrich, V. Král, M. Pechar, 2013, Biomacromolecules.

Cloning, Bacterial Expression, and Characterization of the Mason-Pfizer Monkey Virus Proteinase (*)

P. Štrop, M. Andreánsky, I. Bláha, 1995, The Journal of Biological Chemistry.

Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors.

J. Hašek, J. Konvalinka, T. Skálová, 2004, European journal of biochemistry.

Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor.

J. Hašek, J. Konvalinka, J. Dušková, 2002, Journal of medicinal chemistry.

On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution.

J. Hašek, J. Konvalinka, T. Skálová, 2006, Acta crystallographica. Section D, Biological crystallography.

Structure of the mouse galectin-4 N-terminal carbohydrate-recognition domain reveals the mechanism of oligosaccharide recognition.

J. Brynda, P. Malý, P. Řezáčová, 2011, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray diffraction analysis of mouse galectin-4 N-terminal carbohydrate recognition domain in complex with lactose.

J. Brynda, P. Malý, P. Řezáčová, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Myeloblastosis associated virus (MAV) proteinase site-mutated to be HIV-like has a higher activity and allows production of infectious but morphologically altered virus.

P. Štrop, J. Sedláček, R. Luftig, 1993, Virology.

Polymer Cancerostatics Targeted with an Antibody Fragment Bound via a Coiled Coil Motif: In Vivo Therapeutic Efficacy against Murine BCL1 Leukemia.

V. Král, O. Janoušková, M. Pechar, 2018, Macromolecular Bioscience.

Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.

H. Berchtold, J. Knolle, J. Sedláček, 1997, European journal of biochemistry.

Inhibitor–Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms

V. Šubr, V. Král, J. Konvalinka, 2019, ACS Omega.

Structural Studies of Mouse Galectin-4 N-Terminal Domain

P. Malý, M. Fábry, G. Jenikova, 2003 .

Heterogeneity of insulin receptors in rat tissues as detected with the partial agonist B29,B29'-suberoyl-insulin.

H. Joost, W. Becker, D. Müller-Wieland, 1993, Molecular pharmacology.

Mutagenesis, biochemical characterization and X-ray structural analysis of point mutants of bovine chymosin.

T. Blundell, J. Pitts, V. Dhanaraj, 1997, Protein engineering.

Multivalency of nucleosome recognition by LEDGF

V. Veverka, J. Nováček, P. Srb, 2023, Nucleic acids research.