K. Vastag

发表

pH-dependent oral absorption of L-735,524, a potent HIV protease inhibitor, in rats and dogs.

J. Lin, I. Chen, D. Ostovic, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Efficacious, orally bioavailable thrombin inhibitors based on 3-aminopyridinone or 3-aminopyrazinone acetamide peptidomimetic templates.

J. Vacca, J. Shafer, Z. Chen, 1998, Journal of medicinal chemistry.

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.

J. Vacca, J. Shafer, Z. Chen, 1998, Bioorganic & medicinal chemistry letters.

C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption.

J. Vacca, S. Gardell, S. D. Lewis, 1998, Bioorganic & medicinal chemistry letters.

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.

C. Coburn, J. Vacca, S. D. Lewis, 2000, Bioorganic & medicinal chemistry letters.

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.

C. Coburn, J. Vacca, S. D. Lewis, 2000, Bioorganic & medicinal chemistry letters.

Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption

B. E. Evans, P. Anderson, Jiunn H. Lin, 1995 .

High-performance liquid chromatographic determination of a potent and selective HIV protease inhibitor (L-735,524) in rat, dog and monkey plasma.

J. Lin, I. Chen, K. Vastag, 1995, Journal of chromatography. B, Biomedical applications.

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

S K Balani, J. Lin, M. Chiba, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence.

J. Lin, M. Chiba, I. Chen, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

P. Anderson, P. Darke, W. Schleif, 1995 .

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

P. Anderson, P. Darke, W. Schleif, 1995 .

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

P. Anderson, P. Darke, W. Schleif, 1994 .

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.

S. Brady, J. Vacca, S. Gardell, 1998, Journal of medicinal chemistry.

Metabolite-P450 complex formation by methylenedioxyphenyl HIV protease inhibitors in rat and human liver microsomes.

J. Vacca, J. Lin, M. Chiba, 1998, Biochemical pharmacology.