Eung-Seok Lee

发表

Reactivity and suitability oft-boc-protected thiophosphotyrosine intermediate analogs for the solid or solution phase peptide synthesis

Eun-kyung Kim, Heesung Choi, Eung-Seok Lee, 1998, Archives of pharmacal research.

Preparation of an angiotensin i analog containing a p-phosphonomethyl-l-phenylalanine residue via asymmetric synthesis of t-boc-p- dimethylphosphonomethyl-l-phenylalanine

M. Cushman, Eung-Seok Lee, 1992 .

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

T. Jeong, Sangkyu Lee, M. Kang, 2018, Pharmaceutics.

Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells.

M. J. Kim, D. Sohn, Saroj Nepal, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification of a N7-guanine adduct of 1-bromopropane in calf thymus DNA by mass spectrometry

H. Jeong, T. Jeong, Sangkyu Lee, 2016, Molecular & Cellular Toxicology.

Depurination of Nucleosides and Calf Thymus DNA Induced by 2-Bromopropane at the Physiological Condition

Eung-Seok Lee, Jyoti Sherchan, Hoyoung Choi, 2009 .

Depurination of dA and dG Induced by 2-bromopropane at the Physiological Condition

T. Jeong, Pritam Thapa, Eung-Seok Lee, 2007 .

Acute effects of 2-bromopropane and 1,2-dibromopropane on hepatotoxic and immunotoxic parameters in female BALB/c mice

T. Jeong, N. Kim, S. Hyun, 2003, Archives of pharmacal research.

Ethanol increases matrix metalloproteinase-12 expression via NADPH oxidase-dependent ROS production in macrophages.

M. J. Kim, Saroj Nepal, Sang-Hyun Kim, 2013, Toxicology and applied pharmacology.

Novel protein kinase C inhibitors: α-terthiophene derivatives

C. Ashendel, Darrick S. H. L. Kim, D. S. Kim, 1998 .

Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells.

D. Nam, T. Jeong, Jung-Ae Kim, 2002, Cancer letters.

Hydroxychalcones as Potential Anti-Angiogenic Agent

Jung-Ae Kim, Youra Kang, Eung-Seok Lee, 2012 .

The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced signaling.

M. Kwak, K. Kang, S. Mousa, 2009, Vascular pharmacology.

Synthesis of novel oleanolic acid and ursolic acid in C-28 position derivatives as potential anticancer agents

Chun-hui Zhao, Xinyu Liu, Eung-Seok Lee, 2017, Archives of pharmacal research.

Synthesis and structure-activity relationships of hydroxylated and halogenated 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols as selective topoisomerase IIα inhibitors.

Youngjoo Kwon, G. Bist, Eung-Seok Lee, 2021, Bioorganic chemistry.

Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.

H. Chang, T. Jeong, H. Ju, 2004, Bioorganic & medicinal chemistry letters.

A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships.

Youngjoo Kwon, Eung-Seok Lee, Aarajana Shrestha, 2018, Bioorganic & medicinal chemistry.

Inhibition of Ca(2+) release-activated Ca(2+) channel (CRAC) by curcumin and caffeic acid phenethyl ester (CAPE) via electrophilic addition to a cysteine residue of Orai1.

Dong-Hoon Shin, Sung Joon Kim, J. Nam, 2012, Biochemical and biophysical research communications.

Hepatotoxic and Immunotoxic Effects produced by 1,3‐Dibromopropane and Its Conjugation with Glutathione in Female BALB/c Mice

D. Nam, H. Chang, T. Jeong, 2007, Journal of toxicology and environmental health. Part A.

Inhibition of LPS-stimulated ROS production by fluorinated and hydroxylated chalcones in RAW 264.7 macrophages with structure-activity relationship study.

P. Park, N. Pun, G. Bist, 2017, Bioorganic & medicinal chemistry letters.

Activation of the Nrf2‐antioxidant system by a novel cyclooxygenase‐2 inhibitor furan‐2‐yl‐3‐pyridin‐2‐yl‐propenone: implication in anti‐inflammatory function by Nrf2 activator

M. Kwak, Jung-Ae Kim, A. You, 2008, The Journal of pharmacy and pharmacology.

Chemopreventive effects of Furan-2-yl-3-pyridin-2-yl-propenone against 7,12-dimethylbenz[a]anthracene-inducible genotoxicity.

Hyung Gyun Kim, E. Han, Y. Hwang, 2008, Toxicology and applied pharmacology.

Suppression of CYP1A1 expression by naringenin in murine Hepa-1c1c7 cells

E. Han, H. Jeong, Ji Young Kim, 2004, Archives of pharmacal research.

Hydroxyl‐ and Halogen‐containing Chalcones for the Inhibition of LPS‐stimulated ROS Production in RAW 264.7 Macrophages: Design, Synthesis and Structure–Activity Relationship Study

P. Park, Eung-Seok Lee, Aarajana Shrestha, 2019, Bulletin of the Korean Chemical Society.

Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.

Eung-Seok Lee, Youngjoo Kwon, Surendra Kunwar, 2022, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Fluorinated and/or Hydroxylated 2‐Arylidene‐1‐indanone Derivatives as an Inhibitor of LPS‐stimulated ROS Production in RAW 264.7 Macrophages with Structure–Activity Relationship Study

P. Park, Eung-Seok Lee, Aarajana Shrestha, 2018, Bulletin of the Korean Chemical Society.

Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor.

Youngjoo Kwon, Hwa-Jong Lee, T. Kadayat, 2017, European journal of medicinal chemistry.

Methoxychlor-induced inducible nitric oxide synthase and proinflammatory cytokines expression in macrophages via NF-kappaB, ERK, and p38 mitogen-activated protein kinases.

E. Han, H. Jeong, Ji Young Kim, 2005, Biochemical and biophysical research communications.

Effects of flupyrazofos on liver microsomal cytochrome P450 in the male Fischer 344 rat

Jung-Ae Kim, C. Yun, Eung-Seok Lee, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of polycyclic aromatic hydrocarbons on liver and lung cytochrome P450s in Mice

Ji Young Kim, T. Jeong, S. Yoo, 2003, Archives of pharmacal research.

YJI-7 Suppresses ROS Production and Expression of Inflammatory Mediators via Modulation of p38MAPK and JNK Signaling in RAW 264.7 Macrophages

P. Park, Eun Hye Kim, N. Pun, 2017, Biomolecules & therapeutics.

Progress in the Studies on Rutaecarpine

T. Jeong, Seung Ho Lee, Y. Jahng, 2008, Molecules.

NADPH oxidase inhibitors: a patent review

Jung-Ae Kim, G. Neupane, Byeong-Seon Jeong, 2011, Expert opinion on therapeutic patents.

Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes.

Jung-Ae Kim, Da-qing Jin, Eung-Seok Lee, 2003, European journal of pharmacology.

A novel anti‐cancer agent, FPDHP, induces anoikis in various human cancer cells through activation of calpain, and downregulation of anoikis‐related molecules

Dong Eun Kim, T. Kwon, Shin Kim, 2018, Journal of cellular biochemistry.

Potent Inhibitory Activity of Hydroxylated 2-Benzylidene-3,4-dihydronaphthalen-1(2H)-ones on LPS-stimulated Reactive Oxygen Species Production in RAW 264.7 Macrophages.

P. Park, Eung-Seok Lee, Aarajana Shrestha, 2022, Bioorganic & medicinal chemistry letters.

Ginsenoside RB1 the anti-ulcer constituent from the head ofPanax ginseng

Yeong Shik Kim, C. Jeong, Eung-Seok Lee, 2003, Archives of pharmacal research.

Design, synthesis, and structure-activity relationship study of halogen containing 2-benzylidene-1-indanone derivatives for inhibition of LPS-stimulated ROS production in RAW 264.7 macrophages.

M. J. Kim, P. Park, N. Pun, 2017, European journal of medicinal chemistry.

Inhibitory Activity of Halogenated 3‐Benzylidenechroman‐4‐ones Against Lipopolysaccharide‐stimulated Reactive Oxygen Species Production in RAW 264.7 Macrophages

P. Park, T. Kadayat, Eung-Seok Lee, 2017 .

Design, synthesis and anticonvulsive activity of analogs of γ-vinyl GABA

T. Jeong, Jongwon Choi, Y. Jahng, 2004 .

SKF 525-A INDUCES COCAINE N-DEMETHYLASE, ETHOXYRESORUFIN O-DEETHYLASE, AND PENTOXYRESORUFIN O-DEALKYLASE ACTIVITIES BY INDUCTION OF CYTOCHROME P-450 2B IN FEMALE B6C3F1 MICE

H. Jeong, H. Chang, T. Jeong, 2004, Journal of toxicology and environmental health. Part A.

1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP.

M. Kwak, Han‐Gon Choi, D. Thapa, 2007, European journal of pharmacology.

1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression of NF-κB activation and IL-8 induction.

S. Ku, Jung-Ae Kim, Eung-Seok Lee, 2012, Chemico-biological interactions.

TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1

M. J. Kim, P. Park, D. Kim, 2014, Biomolecules & Therapeutics.

Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s.

H. Chang, T. Jeong, Han‐Gon Choi, 2004, Planta medica.

Asiatic Acid Derivatives Protect Primary Cultures of Rat Hepatocytes against Carbon Tetrachloride-Induced Injury via the Cellular Antioxidant System

Mi Kyeong Lee, S. Sung, Y. C. Kim, 2009, Natural product communications.

Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study.

Youngjoo Kwon, T. Kadayat, Eung-Seok Lee, 2015, Bioorganic chemistry.

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines.

Y. Na, Youngjoo Kwon, Pritam Thapa, 2015, Bioorganic & medicinal chemistry.

Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity.

Youngjoo Kwon, Kyu-Yeon Jun, T. Kadayat, 2015, Bioorganic & medicinal chemistry.

Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

P. Park, W. Cho, Youngjoo Kwon, 2012, European journal of medicinal chemistry.

Identification of DNA and glutathione adducts in male Sprague–Dawley rats exposed to 1-bromopropane

T. Jeong, K. Noh, M. Nepal, 2019, Journal of toxicology and environmental health. Part A.

The phenyl-thiophenyl propenone RK-I-123 reduces the levels of reactive oxygen species and suppresses the activation of NF-κB and AP-1 and IL-8 expression in Helicobacter pylori-infected gastric epithelial AGS cells

Jung Mogg Kim, Hyeyoung Kim, Eung-Seok Lee, 2013, Inflammation Research.

2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.

Y. Na, W. Cho, Youngjoo Kwon, 2010, Bioorganic & medicinal chemistry letters.

2,6-Dithienyl-4-arylpyridines: Synthesis, Topoisomerase I and II Inhibition and Structure—Activity Relationship.

Eung-Seok Lee, 2009 .

2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

T. Jeong, Y. Na, Y. Jahng, 2007, Bioorganic & medicinal chemistry.

Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits ofEvodia officinalis

H. Chang, Seung-Ho Lee, M. Woo, 2006, Archives of pharmacal research.

One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine.

Seung Ho Lee, Y. Jahng, C. Seo, 2008, Chemical & pharmaceutical bulletin.

Synthesis, Cytotoxicity and Topoisomerase II Inhibition Study of New Thioxanthone Analogues.

Y. Na, Youngjoo Kwon, Y. Jahng, 2008 .

Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase IIα-targeted Chemotherapeutic Agents for Breast Cancer.

T. Jeong, Kil-Soo Kim, Youngjoo Kwon, 2019, Journal of medicinal chemistry.

Synthesis, topoisomerase I inhibition and structure-activity relationship study of 2,4,6-trisubstituted pyridine derivatives.

T. Jeong, Sun-Young Lee, Sang-Un Choi, 2004, Bioorganic & medicinal chemistry letters.

Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA.

Kyung-Tae Lee, W. Cho, C. Ahn, 2010, European journal of medicinal chemistry.

New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor.

Y. Na, Youngjoo Kwon, Y. Jahng, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities.

T. Jeong, Y. Na, Y. Jahng, 2008, European journal of medicinal chemistry.

Synthesis, cytotoxicity and structure-activity relationship study of terpyridines

Jung Ki Park, T. Jeong, Y. Jahng, 2006, Archives of pharmacal research.

Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Y. Na, W. Cho, Youngjoo Kwon, 2011, European journal of medicinal chemistry.

Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors.

M. Seo, Youngjoo Kwon, T. Kadayat, 2021, European journal of medicinal chemistry.

Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors.

Y. Na, Youngjoo Kwon, Kyu-Yeon Jun, 2016, European journal of medicinal chemistry.

Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor.

Y. Na, Youngjoo Kwon, Kyu-Yeon Jun, 2011, European journal of medicinal chemistry.

Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues.

Y. Na, Youngjoo Kwon, Eun-Mi Ha, 2010, European journal of medicinal chemistry.

New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.

Y. Na, Youngjoo Kwon, M. Jung, 2010, Bioorganic & medicinal chemistry.

Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents.

S. Seo, Youngjoo Kwon, T. Kadayat, 2018, Bioorganic & medicinal chemistry.

Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.

Y. Na, Youngjoo Kwon, Kyu-Yeon Jun, 2015, Bioorganic & medicinal chemistry.

A facile synthesis of α,α-bis (substituted -benzylidene )-cycloalkanones and substituted-benzylidene heteroaromatics : utility of NaOAc as a catalyst for aldol-type reaction

Jung Ki Park, A. Rahman, Y. Jahng, 2007 .

A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases.

S. Rho, Y. Na, Youngjoo Kwon, 2015, Journal of medicinal chemistry.

Potent analgesic and anti-inflammatory activities of 1-furan-2-yl-3-pyridin-2-yl-propenone with gastric ulcer sparing effect.

Han‐Gon Choi, C. Yong, Jung-Ae Kim, 2006, Biological & pharmaceutical bulletin.

Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study.

I. Park, W. Cho, Eung-Seok Lee, 2002, Bioorganic & medicinal chemistry.

6‐Hydroxy ‐benzofuran‐3‐( 2 H )‐ones as Potential Anti‐Inflammatory Agents: Synthesis and Inhibitory Activity of LPS ‐Stimulated ROS Production in RAW 264.7 Macrophage

P. Park, Eung-Seok Lee, Aarajana Shrestha, 2021 .

A Facile Synthesis of Simple Alkaloids — Synthesis of 2,3-Polymethylene-4(3H)-quinazolinones and Related Alkaloids.

Y. Jahng, Eung-Seok Lee, Jae-Gyu Park, 2003 .

A facile synthesis of simple alkaloids—synthesis of 2,3-polymethylene-4(3H)-quinazolinones and related alkaloids

Y. Jahng, Eung-Seok Lee, Jae-Gyu Park, 2003 .

A Simple Synthesis of Rutaecarpine

Y. Jahng, Seung Ho Lee, Jae Gyu Park, 2001 .

Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.

Youngjoo Kwon, Kyu-Yeon Jun, T. Kadayat, 2017, European journal of medicinal chemistry.

Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines.

Y. Na, Youngjoo Kwon, Kyu-Yeon Jun, 2016, Bioorganic & medicinal chemistry letters.

Hydroxylated 2,4-diphenyl indenopyridine derivatives as a selective non-intercalative topoisomerase IIα catalytic inhibitor.

Youngjoo Kwon, Kyu-Yeon Jun, T. Kadayat, 2015, European journal of medicinal chemistry.

Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors.

Sang Kook Lee, W. Cho, Youngjoo Kwon, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors.

Y. Na, Youngjoo Kwon, Eung-Seok Lee, 2013, Bioorganic chemistry.

Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives

T. Moon, H. Chang, T. Jeong, 2005 .

Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Y. Na, W. Cho, Youngjoo Kwon, 2010, Bioorganic & medicinal chemistry.

Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines.

Y. Na, Youngjoo Kwon, T. Kadayat, 2010, Bioorganic & medicinal chemistry.

New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases

Seung Ho Lee, Y. Jahng, Eung-Seok Lee, 2012, Archives of pharmacal research.

Synthesis and Biological Properties of Luotonin a Derivatives

A. Rahman, Y. Na, Youngjoo Kwon, 2008 .

Acetate-Promoted Aldol-Type Reaction: Scope and Reactivity of Acetates and Aldehydes

A. Rahman, Y. Jahng, Byeong-Seon Jeong, 2009 .

SYNTHESIS AND BIOLOGICAL PROPERTIES OF SELECTED 2-ARYL-4(3H)-QUINAZOLINONES

Y. Na, Y. Jahng, J. Son, 2004 .

Synthesis and Properties of Luotonin A Homologues and Their Aza-analogues

Y. Jahng, Jae Gyu Park, Eung-Seok Lee, 2006 .

Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study

M. J. Kim, P. Park, T. Kadayat, 2014 .

Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety.

Y. Na, W. Cho, Youngjoo Kwon, 2012, European journal of medicinal chemistry.

Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison.

Youngjoo Kwon, Kyu-Yeon Jun, T. Kadayat, 2015, European journal of medicinal chemistry.

Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo(h)quinoline Moiety

Y. Na, Youngjoo Kwon, Eun-Mi Ha, 2011 .

Reduced renal toxicity of nanoparticular amphotericin B micelles prepared with partially benzylated poly-L-aspartic acid.

B. Yoo, Kun Han, Eung-Seok Lee, 2006, Biological & pharmaceutical bulletin.

Synthesis of 2,4,6-Tripyridyl Pyridines, and Evaluation of Their Antitumor Cytotoxicity, Topoisomerase I and II Inhibitory Activity, and Structure-activity Relationship

Byeong-Seon Jeong, Eung-Seok Lee, Hoyoung Choi, 2011 .

2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

Y. Na, Youngjoo Kwon, Y. Jahng, 2010, Bioorganic & medicinal chemistry.

Synthesis of decapeptide ofl-aspartic acid and benzyl-l-aspartic acid by solid phase peptide synthesis

B. Yoo, Kun Han, M. A. Jalil Miah, 2005 .

Modification of C2,3,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects

Byeong-Seon Jeong, Eung-Seok Lee, Young Choong Kim, 2007 .

A new stilbene glucoside from the roots ofPolygonum multiflorum Thunb.

H. Chang, M. Zheng, Seung-Ho Lee, 2006, Archives of pharmacal research.

Modification of C2,3,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects.

Byeong-Seon Jeong, Eung-Seok Lee, Young Choong Kim, 2007 .

Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects

Mi Kyeong Lee, Y. C. Kim, Byeong-Seon Jeong, 2007, Archives of pharmacal research.

Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells.

K. Bosire, Jung-Ae Kim, Yong Soo Lee, 2005, Cancer letters.

Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators

Ju-Hyun Kim, T. Jeong, Sangkyu Lee, 2019, Pharmaceutics.

Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.

J. Jee, Jun-Ho Lee, Kyu-Yeon Jun, 2014, European journal of medicinal chemistry.

Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease.

W. Suo, Mukut Sharma, S. Upadhyay, 2021, Bioorganic chemistry.

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex.

T. S. Kim, W. Cho, Kwang Youl Lee, 2007, Bioorganic & medicinal chemistry letters.

Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects

Hyeung‐geun Park, Y. Jahng, Byeong-Seon Jeong, 2007 .

Role of glutathione conjugation in the hepatotoxicity and immunotoxicity induced by 1‐bromopropane in female BALB/c mice

H. Jeong, T. Jeong, T. Jeon, 2007, Journal of applied toxicology : JAT.

Hepatotoxic effect of 1-bromopropane and its conjugation with glutathione in male ICR mice

T. Jeong, T. Jeon, Eung-Seok Lee, 2005, Archives of pharmacal research.

Prenylated Flavanones from Derris laxiflora

R. Geahlen, C. Ashendel, Young Ho Kim, 1995 .

Synthesis of [L-3-Deoxymimosine4]-angiotensin I as an approach to the preparation of selective protein-tyrosine kinase (PTK) inhibitors

J. Jurayj, M. Cushman, Eung-Seok Lee, 1994 .

Pretreatment with 1,8-cineole potentiates thioacetamide-lnduced hepatotoxicity and immunosuppression

Y. Chun, T. Jeong, N. Kim, 2004, Archives of pharmacal research.

Deguanylation of Guanine Based-Nucleosides and Calf Thymus DNA Induced by Halogenated Alkanes at the Physiological Condition

Eung-Seok Lee, Jyoti Sherchan, 2009 .

Inhibition of Nitric Oxide and Tumor Necrosis Factor-α (TNF-α) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-κB Activation in Cultured Murine Macrophages

H. Chang, Eunkyung Lee, S. Baek, 2004 .

Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.

W. Cho, H. Jeong, Eung-Seok Lee, 2014, European journal of medicinal chemistry.

Immunotoxicological Investigation of 1-furan-2-yl-3-pyridin-2-yl-propenone in Female BALB/c Mice

H. Jeong, T. Jeong, Sangkyu Lee, 2009 .

Hepatotoxic Effects of 1-Furan-2-yl-3-pyridin-2-yl-propenone, a New Anti-Inflammatory Agent, in Mice

J. Choi, Sang-Hyun Kim, T. Jeong, 2009 .

The effect of 1-furan-2-yl-3-pyridine-2-yl-propenone on pharmacokinetic parameters of warfarin

S. Shanmugam, T. Jeong, Han‐Gon Choi, 2007, Archives of pharmacal research.

Metabolism of FPP-3, an anti-inflammatory propenone compound, in rat by liquid chromatography-electrospray ionization tandem mass spectrometry.

H. Jeong, T. Jeong, Eung-Seok Lee, 2007, Biological & pharmaceutical bulletin.

Identification of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory agent, and its metabolites in rat liver subcellular fractions

H. Jeong, T. Jeong, T. Jeon, 2006, Archives of pharmacal research.

Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry.

T. Jeong, T. Jeon, Eung-Seok Lee, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The effect of 1-furan-2-yl-3-pyridine-2-yl-propenone on pharmacokinetic parameters of theophylline.

S. Shanmugam, B. Yoo, C. Yong, 2006, Biological & pharmaceutical bulletin.

Cytotoxic constituents isolated from the fruit bodies ofHypsizigus marmoreus

H. Chang, Seung-Ho Lee, M. Woo, 2007, Archives of pharmacal research.

Cytokine-mediated induction of metallothionein in Hepa-1c1c7 cells by oleanolic acid.

H. Jeong, Ji Young Kim, T. Jeong, 2004, Biochemical and biophysical research communications.

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling.

Kyung-Tae Lee, W. Cho, Eung-Seok Lee, 2011, Bioorganic & medicinal chemistry.

Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors.

Kyung-Tae Lee, W. Cho, Eung-Seok Lee, 2011, Bioorganic & medicinal chemistry.

Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.

G. Bist, Eung-Seok Lee, Seojeong Park, 2017, European journal of medicinal chemistry.

Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling

M. J. Kim, P. Park, T. Jeong, 2015, Biomolecules & therapeutics.

Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.

S. Banskota, Jung-Ae Kim, T. Kadayat, 2018, Bioorganic & medicinal chemistry letters.

Ameliorating effect of TI‐1‐162, a hydroxyindenone derivative, against TNBS‐induced rat colitis is mediated through suppression of RIP/ASK‐1/MAPK signaling

T. Jeong, S. Banskota, D. Choi, 2018, European journal of pharmacology.

Down-regulation of Bcl-2 is mediated by NF-κB activation in Helicobacter pylori-induced apoptosis of gastric epithelial cells

Hyeyoung Kim, S. Chu, J. Lim, 2011, Scandinavian journal of gastroenterology.

Inhibitory effects of asiatic acid on 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice.

Han‐Gon Choi, C. Yong, Jung-Ae Kim, 2007, Biological & pharmaceutical bulletin.

The anti-angiogenic and anti-tumor activity of synthetic phenylpropenone derivatives is mediated through the inhibition of receptor tyrosine kinases.

D. Thapa, Youra Kang, Jong Tae Kim, 2012, European journal of pharmacology.

A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.

Y. Na, T. Kadayat, G. Bist, 2016, European journal of medicinal chemistry.

Globular adiponectin modulates expression of programmed cell death 4 and miR‐21 in RAW 264.7 macrophages through the MAPK/NF‐κB pathway

W. Park, D. Sohn, Saroj Nepal, 2013, FEBS letters.

2,4-Diaryl-5,6-dihydro-1,10-phenanthrolines with Furyl or Thienyl Moiety at 4-Position: Synthesis, Topoisomerase I and II Inhibitory Activity, and Cytotoxicity

Pritam Thapa, Eung-Seok Lee, 2012 .

2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

P. Park, Y. Na, W. Cho, 2012, Bioorganic chemistry.

FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells.

T. Kwon, B. Jang, Jong-Wook Park, 2014, International journal of molecular medicine.

Synthesis, Topoisomerase I and II Inhibitory Activities, and Cytotoxicity of 4,6-Diaryl-2,4'-bipyridine Derivatives

Pritam Thapa, Eung-Seok Lee, Radha Karki, 2010 .

Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors.

Hyunji Jo, Eung-Seok Lee, Y. Kwon, 2018, Bioorganic & medicinal chemistry letters.

2,4-Diaryl-5H-chromeno [4,3-b]pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, and Cytotoxicity

Pritam Thapa, Eung-Seok Lee, 2012 .

AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells

Eung-Seok Lee, Seojeong Park, Youngjoo Kwon, 2021, International journal of molecular sciences.

Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.

T. Kadayat, Eung-Seok Lee, Daeun Kim, 2021, European journal of medicinal chemistry.

2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.

Hwa-Jong Lee, T. Kadayat, G. Bist, 2017, Bioorganic & medicinal chemistry letters.

Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.

Y. Na, Seok-Ho Kim, Eung-Seok Lee, 2013, Bioorganic & medicinal chemistry letters.

Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase IIα

M. Seo, Eung-Seok Lee, Jeong-Ahn Kim, 2021, Biomolecules & therapeutics.

IMMUNOTOXIC EFFECTS OF 2-BROMOPROPANE IN MALE SPRAGUE-DAWLEY RATS: A 28-DAY EXPOSURE STUDY

T. Jeong, B. Kang, Eung-Seok Lee, 2002, Journal of toxicology and environmental health. Part A.

Synthesis, characterization andIn vitro identification ofN7-Guanine adduct of 2-bromopropane

T. Jeong, Nam-Hee Kim, Eun-kyung Kim, 2002, Archives of pharmacal research.

Hydrophobic binding peptide-conjugated hybrid lipid-mesoporous silica nanoparticles for effective chemo-photothermal therapy of pancreatic cancer

S. Ku, Han‐Gon Choi, Jong Oh Kim, 2017, Drug delivery.

Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor.

Pritam Thapa, Eung-Seok Lee, Radha Karki, 2014, European journal of medicinal chemistry.

Induction of cytochrome p450 1a and 2b by α-and β-lonone in sprague dawley rats

H. Jeong, Y. Chun, T. Jeong, 2002 .

Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

M. J. Kim, D. Sohn, J. Hong, 2015, Oncotarget.

Design and synthesis of anticonvulsive agents as γ-vinyl GABA-based potential dual acting prodrugs and their biological activities

Yong‐Chul Kim, Y. Jahng, Eun-kyung Kim, 2000 .

Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain

T. Jeong, Y. Jahng, Jae Gyu Park, 2003, Archives of pharmacal research.

Design and Synthesis of Anticonvulsive Agents as γ-Vinyl GABA-Based Potential Dual Acting Prodrugs and Their Biological Activities.

Eung-Seok Lee, 2000 .

Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 induction.

M. J. Kim, Saroj Nepal, P. Park, 2012, Biochemical pharmacology.

Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein

S. Shanmugam, Han‐Gon Choi, B. Yoo, 2010, Archives of pharmacal research.

Two New Diarylheptanoids from Juglans mandshurica

H. Chang, M. Woo, Y. Jahng, 2005 .

3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.

Y. Na, Eung-Seok Lee, Eunyoung Lee, 2013, European journal of medicinal chemistry.

4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships.

M. Seo, Eung-Seok Lee, Youngjoo Kwon, 2021, Bioorganic chemistry.

Introduction of amino moiety enhances the inhibitory potency of 1-tetralone chalcone derivatives against LPS-stimulated reactive oxygen species production in RAW 264.7 macrophages.

P. Park, Eung-Seok Lee, Aastha Shrestha, 2019, Bioorganic chemistry.

Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.

S. Banskota, Jung-Ae Kim, T. Kadayat, 2017, European journal of medicinal chemistry.

Selective inhibitory effects of HYIpro‐3‐1 on CYP1A2 in human liver microsomes

T. Jeong, J. Bae, Sangkyu Lee, 2021, Biopharmaceutics & drug disposition.

Identification of sulfonyl‐loxoprofen as novel phase 2 conjugate in rat

T. Jeong, Sangkyu Lee, Taeho Lee, 2019, Biopharmaceutics & drug disposition.

Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines.

G. Bist, Eung-Seok Lee, Seojeong Park, 2018, Bioorganic chemistry.

Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.

Y. Na, Pritam Thapa, T. Kadayat, 2016, Bioorganic chemistry.

In vitro characterization of the enzymes involved in the metabolism of 1-Furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound

H. Jeong, T. Jeong, Ju ng-Hyun Kim, 2008, Archives of pharmacal research.

Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure-activity relationships.

M. Seo, Yi Liu, Hyunji Jo, 2023, Bioorganic & medicinal chemistry.

Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines.

Y. Na, T. Kadayat, G. Bist, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues.

Youngsoo Kim, Y. Na, Eun-Mi Ha, 2011, Bioorganic & medicinal chemistry.

Lignans from the roots of Saururus chinensis.

Eung-Seok Lee, H. Chang, M. Zheng, 2008, Journal of natural products.

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines.

T. Jeong, Y. Na, W. Cho, 2010, Bioorganic & medicinal chemistry.