B. Harrison

发表

A Diels-Alder macrocyclization enables an efficient asymmetric synthesis of the antibacterial natural product abyssomicin C.

E. J. Sorensen, C. Zapf, B. Harrison, 2005, Angewandte Chemie.

LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice

Alan G. E. Wilson, N. C. Goodwin, F. Mseeh, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.

D. Burnett, Raksha A. Acharya, H. Patzke, 2017, Journal of medicinal chemistry.

LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2

Alan G. E. Wilson, N. C. Goodwin, F. Mseeh, 2015, Pharmacology research & perspectives.

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3–sp2 Suzuki Coupling of a Benzyl Carbonate

B. Harrison, Lauren E. Sirois, Ngiap-Kie Lim, 2019, Organic Process Research & Development.

Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.

Alan G. E. Wilson, Y. Liu, D. Rice, 2009, Journal of medicinal chemistry.

Unpredictable stereochemical preferences for mu opioid receptor activity in an exhaustively stereodiversified library of 1,4-enediols.

G. Verdine, Zhangjie Shi, B. Harrison, 2003, Organic letters.

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Alan G. E. Wilson, N. C. Goodwin, F. Mseeh, 2009, Journal of medicinal chemistry.

Strategic and Tactical Approaches to the Synthesis of 5,6-Dihydro-[1,2,4]oxadiazines

W. Zonneveld, E. Heijne, D. Burnett, 2016 .

Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon?

M. Bursavich, B. Harrison, J. Blain, 2016, Journal of medicinal chemistry.

Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.

D. Burnett, Raksha A. Acharya, H. Patzke, 2021, Journal of medicinal chemistry.

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

D. Burnett, H. Patzke, Cuyue Tang, 2016, Alzheimer's Research & Therapy.

Sodium Glucose Cotransporter Inhibitors for the Treatment of Diabetes

Ana R. Jesus, T. M. Dore, B. Harrison, 2021, Burger's Medicinal Chemistry and Drug Discovery.

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

Alan G. E. Wilson, N. C. Goodwin, F. Mseeh, 2012, Clinical pharmacology and therapeutics.

High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols.

G. Pasternak, G. Verdine, C. Neilan, 2002, Journal of the American Chemical Society.

Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.

Alan G. E. Wilson, N. C. Goodwin, F. Mseeh, 2017, Journal of medicinal chemistry.

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.

Alan G. E. Wilson, N. C. Goodwin, Y. Liu, 2015, ACS medicinal chemistry letters.

Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.

D. Rice, A. Abuin, B. Gerhardt, 2009, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

D. Burnett, H. Patzke, Cuyue Tang, 2016, Alzheimer's Research & Therapy.

The synthesis of an exhaustively stereodiversified library of cis-1,5 enediols by silyl-tethered ring-closing metathesis.

G. Verdine, B. Harrison, 2001, Organic letters.

2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists.

G. Pasternak, G. Verdine, B. Harrison, 2003, Journal of medicinal chemistry.

Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.

Y. Liu, Nita Patel, David B Rawlins, 2015, ACS medicinal chemistry letters.