C. Giam

发表

Human T-lymphotropic Virus Type I Tax Activates I-κB Kinase by Inhibiting I-κB Kinase-associated Serine/Threonine Protein Phosphatase 2A*

K. Jeang, Baoying Liu, D. Fu, 2003, The Journal of Biological Chemistry.

Posttranslational modification and processing of membrane lipoproteins in bacteria

H. Tokunaga, M. Tokunaga, H. C. Wu, 1983, Journal of cellular biochemistry.

An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300

Y. Nakatani, A. Vassilev, C. Nicot, 1998, Molecular and Cellular Biology.

Human herpesvirus-8-associated disseminated angiosarcoma in an HIV-seronegative woman: report of a case and limited case-control virologic study in vascular tumors.

F. Abdul-Karim, A. Dowlati, S. Remick, 2000, The American journal of medicine.

NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma

E. Harhaj, C. Giam, 2018, The FEBS journal.

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

O. J. Semmes, H. Shih, J. Glover, 2015, PLoS pathogens.

HTLV-1 Tax-Induced Rapid Senescence Is Driven by the Transcriptional Activity of NF-κB and Depends on Chronically Activated IKKα and p65/RelA

H. Shih, S. Philip, H. Zhi, 2012, Journal of Virology.

NF-κB-Induced R-Loops and Genomic Instability in HTLV-1-Infected and Adult T-Cell Leukemia Cells

C. Giam, Nagesh Pasupala, 2022, Viruses.

NF-κB–induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia

T. Waldmann, O. J. Semmes, H. Shih, 2021, Proceedings of the National Academy of Sciences.

Mycobacterium tuberculosis and its purified protein derivative activate expression of the human immunodeficiency virus.

M. Lederman, Z. Toossi, D. Kusner, 1994, Journal of acquired immune deficiency syndromes.

Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB.

I. Boros, W. Huang, L. Zhao, 1994, Proceedings of the National Academy of Sciences of the United States of America.

p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex*

Y. Nakatani, A. Vassilev, R. Harrod, 2000, The Journal of Biological Chemistry.

NF-κB hyper-activation by HTLV-1 Tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ

H. Shih, H. Zhi, Liangpeng Yang, 2011, Retrovirology.

NF-κB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-Sense Protein HBZ

H. Shih, H. Zhi, Liangpeng Yang, 2011, PLoS pathogens.

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis

S. Hinrichs, M. Liang, T. Geisbert, 2002, Journal of Virology.

Abundant synthesis of functional human T-cell leukemia virus type I p40x protein in eucaryotic cells by using a baculovirus expression vector

M. Nerenberg, K. Jeang, G. Khoury, 1987, Journal of virology.

p4Ox Protein in Eucaryotic Cells by Using a Baculovirus Expression Vector

M. Nerenberg, K. Jeang, G. Khoury, 2022 .

Human T cell leukaemia virus type 2 tax protein mediates CC‐chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical pathway

M. Beilke, H. Zhi, C. Giam, 2014, Clinical and experimental immunology.

An Extended α-Helix and Specific Amino Acid Residues Opposite the DNA-binding Surface of the cAMP Response Element Binding Protein Basic Domain Are Important for Human T Cell Lymphotropic Retrovirus Type I Tax Binding*

M. Glover, F. Tie, R. Harrod, 1998, The Journal of Biological Chemistry.

Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G1 Phase of the Cell Cycle

Baoying Liu, Liangpeng Yang, C. Giam, 2008, Journal of Virology.

HTLV-I tax gene product activates transcription via pre-existing cellular factors and cAMP responsive element.

C. Giam, Y. L. Xu, Yi-Ling Xu, 1989, The Journal of biological chemistry.

Regulation of Human T-Lymphotropic Virus Type I Latency and Reactivation by HBZ and Rex

S. Philip, H. Zhi, M. Zahoor, 2014, PLoS pathogens.

HTLV-1 infection of human retinal pigment epithelial cells and inhibition of viral infection by an antibody to ICAM-1.

R. Nussenblatt, Zhuqing Li, Baoying Liu, 2006, Investigative ophthalmology & visual science.

K-bZIP of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 (KSHV/HHV-8) Binds KSHV/HHV-8 Rta and Represses Rta-Mediated Transactivation

H. Kung, W. Liao, C. Giam, 2003, Journal of Virology.

Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2.

M. Beilke, H. Zhi, C. Giam, 2013, Viral immunology.

Recombinant human T-cell leukemia virus types 1 and 2 Tax proteins induce high levels of CC-chemokines and downregulate CCR5 in human peripheral blood mononuclear cells

E. Murphy, M. Beilke, M. Lairmore, 2011, Retrovirology.

Alpha-ketoamide Phe-Pro isostere as a new core structure for the inhibition of HIV protease.

Chi‐Huey Wong, C. Wong, B. Muñoz, 1994, Bioorganic & medicinal chemistry.

Polymyxin B, in combination with fluconazole, exerts a potent fungicidal effect.

Jun Zhang, X. Xiang, B. Zhai, 2010, The Journal of antimicrobial chemotherapy.

HTLV-1 Replication and Adult T Cell Leukemia Development.

C. Giam, 2021, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Modification and processing of internalized signal sequences of prolipoprotein in Escherichia coli and in Bacillus subtilis.

H. C. Wu, S. Hayashi, C. Giam, 1985, The Journal of biological chemistry.

Biogenesis of membrane lipoproteins in Escherichia coli.

H. C. Wu, S. Hayashi, C. Giam, 1982, Biophysical journal.

Assembly of the outer membrane lipoprotein in Escherichia coli.

J. Lin, H. C. Wu, C. Giam, 1980, The Journal of biological chemistry.

Prolipoprotein modification and processing in Escherichia coli. A unique secondary structure in prolipoprotein signal sequence for the recognition by glyceryl transferase.

H. C. Wu, T. Chai, S. Hayashi, 1984, European journal of biochemistry.

Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Transcriptional Activator Rta Is an Oligomeric DNA-Binding Protein That Interacts with Tandem Arrays of Phased A/T-Trinucleotide Motifs

W. Liao, Baoying Liu, Y. Kuo, 2003, Journal of Virology.

No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders.

G. Wood, C. Giam, S. Purvis, 1997, The Journal of investigative dermatology.

High incidence of Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus in tumor lesions and peripheral blood mononuclear cells from patients with Kaposi's sarcoma in Uganda.

C. Elmets, D. Leonard, R. Wallis, 1997, The Journal of infectious diseases.

Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 and Epstein-Barr virus in iatrogenic Kaposi sarcoma.

G. Wood, D. Leonard, C. Giam, 1997, Archives of dermatology.

HTLV-1 Tax and adult T-cell leukemia.

Kuan-Teh Jeang, K. Jeang, Chou-Zen Giam, 2007, Frontiers in bioscience : a journal and virtual library.

Requirement of hCenexin for Proper Mitotic Functions of Polo-Like Kinase 1 at the Centrosomes

Kyung S. Lee, Y. Seong, Keetae Kim, 2006, Molecular and Cellular Biology.

A Human Suppressor of c-Jun N-terminal Kinase 1 Activation by Tumor Necrosis Factor α*

K. Jeang, J. Gutkind, D. Jin, 1997, The Journal of Biological Chemistry.

Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

Yuetsu Tanaka, T. Tsukazaki, N. Mori, 2001, Blood.

KSHV vCyclin Counters the Senescence/G1 Arrest Response Triggered by NF-κB Hyper-activation

H. Zhi, M. Zahoor, C. Giam, 2014, Oncogene.

HTLV-1 and Oncogenesis

C. Giam, 2012 .

Heptad Repeats Regulate Protein Phosphatase 2A Recruitment to I-κB Kinase γ/NF-κB Essential Modulator and Are Targeted by Human T-lymphotropic Virus Type 1 Tax*

H. Shih, H. Kung, Ling-Chi Wang, 2007, Journal of Biological Chemistry.

Versatile Reporter Systems Show that Transactivation by Human T-Cell Leukemia Virus Type 1 Tax Occurs Independently of Chromatin Remodeling Factor BRG1

C. Giam, R. Merling, Meihong Liu, 2006, Journal of Virology.

Activation of the anaphase promoting complex by HTLV‐1 tax leads to senescence

Y. Kuo, C. Giam, 2006, The EMBO journal.

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

I. Boros, M. Liang, W. Liao, 2003, Molecular and Cellular Biology.

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

A. Cereseto, J. Mulloy, C. Nicot, 1998, Journal of Virology.

Cells of adult T-cell leukemia evade HTLV-1 Tax/NF-κB hyperactivation-induced senescence.

Abigail M Druck Shudofsky, C. Giam, 2019, Blood advances.

NF-κB Inhibition Facilitates the Establishment of Cell Lines That Chronically Produce Human T-Lymphotropic Virus Type 1 Viral Particles

S. Philip, H. Zhi, M. Zahoor, 2014, Journal of Virology.

NF-κB Inhibition Facilitates Establishment of Cell Lines Chronically

S. Philip, H. Zhi, M. Zahoor, 2014 .

Complex Cell Cycle Abnormalities Caused by Human T-Lymphotropic Virus Type 1 Tax

M. Schell, H. Zhi, Liangpeng Yang, 2011, Journal of Virology.

Induction of p21CIP1/WAF1 expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization

H. Zhi, Y. Kuo, C. Giam, 2009, Retrovirology.

HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex

Y. Kuo, C. Giam, R. Merling, 2007, Retrovirology.

Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.

K. Jeang, Baoying Liu, D. Fu, 2003, The Journal of biological chemistry.

In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax

B. Cullen, I. Boros, J. Cross, 1994, Molecular and cellular biology.

Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer.

L. Zhao, C. Giam, L. Zhao, 1991, Proceedings of the National Academy of Sciences of the United States of America.

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency*

S. Elledge, Hongyu Miao, K. Gurova, 2015, The Journal of Biological Chemistry.

Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation*

K. Jeang, M. Aboud, C. Giam, 2004, Journal of Biological Chemistry.

Differential immune responsiveness to the immunodominant epitopes of regulatory proteins (tax and rex) in human T cell lymphotropic virus type I-associated myelopathy.

J. Coligan, R. Lal, D. Rudolph, 1994, The Journal of infectious diseases.

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

L. Zhao, C. Giam, L. Zhao, 1992, Proceedings of the National Academy of Sciences of the United States of America.

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ

O. J. Semmes, C. Giam, O. Semmes, 2016, Viruses.

Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat

W. Greene, F. Tie, N. Adya, 1996, Journal of virology.

Cytoplasmic Forms of Human T-Cell Leukemia Virus Type 1 Tax Induce NF-κB Activation

C. Nicot, F. Tie, C. Giam, 1998, Journal of Virology.

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule.

Hongtao Yu, Hongtao Yu, Zhanyun Tang, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 Tax proteins in vitro.

M. Beilke, Li Wu, C. Giam, 2013, AIDS research and human retroviruses.

In vitro association of empty adenovirus capsids with double-stranded DNA

C. Tibbetts, C. Giam, 1979, Journal of virology.

Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax.

H. Shih, H. Kung, Ling-Chi Wang, 2007, The Journal of biological chemistry.

Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors

N. Adya, C. Giam, 1995, Journal of virology.

Dissecting protein:protein interactions between transcription factors with an RNA aptamer.

A. Ellington, M. Green, N. Adya, 1995, RNA.

In vivo and in vitro autoprocessing of human immunodeficiency virus protease expressed in Escherichia coli.

I. Boros, C. Giam, 1988, The Journal of biological chemistry.

Interaction of bovine leukemia virus transactivator Tax with bZip proteins.

I. Boros, F. Tie, C. Giam, 1995, Virology.

Kinase-inducible domain-like region of HTLV type 1 tax is important for NF-kappaB activation.

R. Harrod, Y. Kuo, C. Giam, 2000, AIDS research and human retroviruses.

Cellular factors involved in transcription and Tax-mediated trans-activation directed by the TGACGT motifs in human T-cell leukemia virus type I promoter.

E. Siores, N. Adya, C. Giam, 1990, The Journal of biological chemistry.

RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia

O. J. Semmes, Xin Guo, H. Zhi, 2020, PLoS pathogens.

HTLV-1 Tax mutants that do not induce G1arrest are disabled in activating the anaphase promoting complex

Y. Kuo, C. Giam, R. Merling, 2007, Retrovirology.

Expression of the complete human T-cell leukemia virus type I pX coding sequence as a functional protein in Escherichia coli.

M. Nerenberg, G. Khoury, G. Jay, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Human T cell leukaemia virus type 2 tax protein mediates CC‐chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical pathway

M. Beilke, H. Zhi, C. Giam, 2014, Clinical and experimental immunology.

Versatile Reporter Systems Show that Transactivation by Human T-Cell Leukemia Virus Type 1 Tax Occurs Independently of Chromatin Remodeling Factor BRG1

C. Giam, R. Merling, Meihong Liu, 2006, Journal of Virology.