J. Lien

发表

Allyl Isothiocyanate Induces Cell Toxicity by Multiple Pathways in Human Breast Cancer Cells.

Hsu‐Feng Lu, Jing-Gung Chung, Chun‐Shu Yu, 2016, The American journal of Chinese medicine.

Suppression of the TNF‐alpha level is mediated by Gan‐Lu‐Yin (traditional Chinese medicine) in human oral cancer cells through the NF‐kappa B, AKT, and ERK‐dependent pathways

Kuang-Chi Lai, Jai-Sing Yang, Jing-Gung Chung, 2016, Environmental toxicology.

The crude extract of Corni Fructus inhibits the migration and invasion of U‐2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase‐2/‐9 by MAPK signaling

Shu-Chun Hsu, Jing-Gung Chung, F. Chueh, 2015, Environmental toxicology.

Synthetic Tryptanthrin Derivatives Induce Cell Cycle Arrest and Apoptosis via Akt and MAPKs in Human Hepatocellular Carcinoma Cells

J. Weng, Jing-Lan Hu, Chih-Shiang Chang, 2021, Biomedicines.

Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways.

Shu-Chun Hsu, Jai-Sing Yang, Jing-Gung Chung, 2013, Anticancer research.

DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling

S. Kuo, J. Lien, Shiu‐Wen Huang, 2016, Oncotarget.

Bisdemethoxycurcumin suppresses human brain glioblastoma multiforme GBM 8401 cell migration and invasion via affecting NF‐κB and MMP‐2 and MMP‐9 signaling pathway in vitro

T. Hsia, R. Wu, Chiung-Ju Chen, 2022, Environmental toxicology.

Demethoxycurcumin Suppresses Proliferation, Migration, and Invasion of Human Brain Glioblastoma Multiforme GBM 8401 Cells via PI3K/Akt Pathway

Po-Yuan Chen, Jing-Gung Chung, F. Chueh, 2021, AntiCancer Research.

Em08red, a dual functional antiproliferative emodin analogue, is a downregulator of ErbB2 expression and inducer of intracellular oxidative stress

Chien-Shu Chen, S. Juang, J. Lien, 2015, Drug design, development and therapy.

Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo

M. Fan, Jing-Gung Chung, N. Tang, 2017, Environmental toxicology.

A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models

Shu-Wha Lin, S. Kuo, Hui-Chin Peng, 2016, Thrombosis and Haemostasis.

NP-184[2-(5-methyl-2-furyl) benzimidazole], a novel orally active antithrombotic agent with dual antiplatelet and anticoagulant activities

S. Kuo, C. Chung, Chien-Hsin Chang, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Anti-Angiogenetic and Anti-Lymphangiogenic Effects of a Novel 2-Aminobenzimidazole Derivative, MFB

J. B. Hsu, Cheng-Yu Chen, M. Hsu, 2022, Frontiers in Oncology.

NP‐313, 2‐acetylamino‐3‐chloro‐1,4‐naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A2 synthesis and calcium entry

S. Kuo, C. Chung, Chien-Hsin Chang, 2011, British journal of pharmacology.

Molecular Interaction of Cytotoxic Anticancer Analogues as Inhibitors of β-Tubulin Protein against UACC-62 Melanoma Cell.

Kuan-Chung Chen, Chi-Rei Wu, J. Lien, 2020, Journal of biochemistry.

Naphthoquinone Derivative PPE8 Induces Endoplasmic Reticulum Stress in p53 Null H1299 Cells

T. Lu, Y. Kuo, Hong-Zin Lee, 2015, Oxidative medicine and cellular longevity.

Evaluation of the antioxidant activity of five endemic Ligustrum species leaves from Taiwan flora in vitro.

Y. Hseu, Chi-Rei Wu, J. Lien, 2011, Food chemistry.

Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model

T. Hsia, Kuang-Chi Lai, Jing-Gung Chung, 2017, Environmental toxicology.

Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress‐ and mitochondria‐dependent signaling pathways

Po-Yuan Chen, Jai-Sing Yang, Jing-Gung Chung, 2013, Environmental toxicology.

Protective Effect of Broussonetia papyrifera against Hydrogen Peroxide-Induced Oxidative Stress in SH-SY5Y Cells

Li-Wei Lin, Chi-Rei Wu, J. Lien, 2009, Bioscience, biotechnology, and biochemistry.

Suppressing VEGF-A/VEGFR-2 Signaling Contributes to the Anti-Angiogenic Effects of PPE8, a Novel Naphthoquinone-Based Compound

M. Hsu, Yu-Han Huang, J. Lien, 2022, Cells.

Anthocyanins from Black Rice (Oryza sativa L.) Demonstrate Antimetastatic Properties by Reducing MMPs and NF-κB Expressions in Human Oral Cancer CAL 27 Cells

M. Fan, Jing-Gung Chung, Hui-Yi Lin, 2015, Nutrition and cancer.

Casticin impairs cell growth and induces cell apoptosis via cell cycle arrest in human oral cancer SCC‐4 cells

M. Fan, Jing-Gung Chung, Kung-Wen Lu, 2018, Environmental toxicology.

Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion

Chi-Rei Wu, Chia-Wen Tsai, J. Lien, 2022, International journal of molecular sciences.

Bp5250 inhibits vascular endothelial growth factor-induced angiogenesis and HIF-1α expression on endothelial cells

S. Kuo, C. Chung, Kuan-Ting Lin, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Antiviral Potential of a Novel Compound CW-33 against Enterovirus A71 via Inhibition of Viral 2A Protease

M. Hour, Cheng-Wen Lin, S. Kung, 2015, Viruses.

Regioselective and reductive cleavage of allyl ethers by NaBH4–HOAc

Chun-Hung Lin, F. Wong, J. Lien, 2013 .

Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2001, Journal of medicinal chemistry.

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

S. Kuo, C. Teng, M. Hour, 2001, Bioorganic & medicinal chemistry letters.

Synthesis of 2-alkoxy 1,4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Chemical & pharmaceutical bulletin.

Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones.

S. Kuo, C. Teng, K. Lee, 1996, Chemical & pharmaceutical bulletin.

Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.

S. Kuo, C. Teng, M. Hour, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and Cytotoxicity of 6‐Pyrrolidinyl‐2‐(2‐Substituted Phenyl)‐4‐Quinazolinones

Jai-Sing Yang, S. Kuo, Li‐Jiau Huang, 2007 .

Effect of Indole‐3‐Acetic Acid Analogs on the Differentiation of HL‐60 Cells

S. Kuo, Li‐Jiau Huang, C. Chen, 2008 .

Regioselective and Reductive Cleavage of Allyl Ethers by NaBH4—HOAc.

Chun-Hung Lin, F. Wong, J. Lien, 2013 .

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.

S. Kuo, Li‐Jiau Huang, C. Teng, 1997, Bioorganic & medicinal chemistry.

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of medicinal chemistry.

Synthesis of 1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole Analogues as Novel Antiplatelet Agents.

Chin‐Chung Wu, S. Kuo, Li‐Jiau Huang, 2010 .

Yuwen02f1 suppresses LPS-induced endotoxemia and adjuvant-induced arthritis primarily through blockade of ROS formation, NFkB and MAPK activation.

S. Kuo, Chien-Hsin Chang, Chun-Chieh Hsu, 2013, Biochemical pharmacology.

Triterpenoid Contents and Anti-Inﬂammatory Properties of the Methanol Extracts of Ligustrum Species Leaves

Y. Hseu, Li-Wei Lin, Chi-Rei Wu, 2010, Molecules.

Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy.

Jai-Sing Yang, T. Lai, Shu-Jen Chang, 2013, International journal of oncology.

Demethoxycurcumin Promotes Macrophage Cell Population and Phagocytosis in WEHI-3 Cell-generated Leukemia BALB/c Mice In Vivo

Kung-Wen Lu, Shu-Fen Peng, Chiung-Ju Chen, 2021, In Vivo.

Gefitinib and curcumin-loaded nanoparticles enhance cell apoptosis in human oral cancer SAS cells in vitro and inhibit SAS cell xenografted tumor in vivo.

Kuang-Chi Lai, Jing-Gung Chung, F. Chueh, 2019, Toxicology and applied pharmacology.

Determination of nalidixic acid by fluorometry with sodium borohydride and hydrogen peroxide.

Sheng-Chih Chen, S. Kuo, J. Lien, 2002, Journal of AOAC International.

Comprehensive evaluation of a novel nuclear factor‐κB inhibitor, quinoclamine, by transcriptomic analysis

S.-L. Wu, S. Chiang, Hsin-Yi Lo, 2009, British journal of pharmacology.

Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo

T. Hsia, Jing-Gung Chung, D. Bau, 2017, Environmental toxicology.

Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways.

Jai-Sing Yang, Jing-Gung Chung, Chun‐Shu Yu, 2012, Journal of agricultural and food chemistry.

Genistein enhances the effects of L‐asparaginase on inducing cell apoptosis in human leukemia cancer HL‐60 cells

T. Hsia, Po-Yuan Chen, Jing-Gung Chung, 2020, Environmental toxicology.

Demethoxycurcumin induces the apoptosis of human lung cancer NCI-H460 cells through the mitochondrial-dependent pathway.

Jing-Gung Chung, J. Lien, W. Hsu, 2015, Oncology reports.

Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor

Jai-Sing Yang, Chao‐Lin Kuo, Jing-Gung Chung, 2012, Evidence-based complementary and alternative medicine : eCAM.

Design, Synthesis and Evaluation of Novel Derivatives of Curcuminoids with Cytotoxicity

Chin-Chuan Hung, J. Lien, Hui-Chang Lin, 2021, International journal of molecular sciences.

Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress

J-S Yang, S. Lan, C. Chiu, 2012, Human & experimental toxicology.

Ouabain Suppresses Cell Migration and Invasion in Human Gastric Cancer AGS Cells Through the Inhibition of MMP Signaling Pathways

T. Hsia, Po-Yuan Chen, Chung‐Hung Chen, 2021, AntiCancer Research.

Tetrandrine inhibits human brain glioblastoma multiforme GBM 8401 cancer cell migration and invasion in vitro

Chao‐Lin Kuo, Jing-Gung Chung, Tzong-Der Way, 2018, Environmental toxicology.

Casticin Inhibits A375.S2 Human Melanoma Cell Migration/Invasion through Downregulating NF-κB and Matrix Metalloproteinase-2 and -1

M. Fan, Jing-Gung Chung, Y. Hsiao, 2016, Molecules.

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

M. Fan, Jing-Gung Chung, Fei-Ting Hsu, 2018, Environmental toxicology.

Crude extract of Euphorbia formosana induces apoptosis of DU145 human prostate cancer cells acts through the caspase‐dependent and independent signaling pathway

Chao‐Lin Kuo, Jing-Gung Chung, Ya-yin Chen, 2016, Environmental toxicology.

Induction of apoptosis by curcumin in murine myelomonocytic leukemia WEHI‐3 cells is mediated via endoplasmic reticulum stress and mitochondria‐dependent pathways

Po-Yuan Chen, Jai-Sing Yang, Jing-Gung Chung, 2013, Environmental toxicology.

Antiviral efficacy of bromo-anilino substituents of 4,5-dihydrofuran-3-carboxylate compound CW-33 against Japanese encephalitis virus.

Yu-Chi Tsai, Cheng-Wen Lin, Su-Hua Huang, 2019, Bioorganic & medicinal chemistry letters.

Structure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus

Cheng-Wen Lin, Su-Hua Huang, H. Lai, 2018, Scientific Reports.

Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload

Chao-Jung Chen, Cheng-Wen Lin, Su-Hua Huang, 2016, International journal of molecular sciences.

Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways.

T. Hsia, M. Fan, Jing-Gung Chung, 2018, The American journal of Chinese medicine.

Maslinic Acid Induces DNA Damage and Impairs DNA Repair in Human Cervical Cancer HeLa Cells

Po-Yuan Chen, Kuang-Chi Lai, Kung-Wen Lu, 2020, AntiCancer Research.

Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling.

S. Kuo, J. Lien, Shiu‐Wen Huang, 2012, Carcinogenesis.

Casticin Induces DNA Damage and Impairs DNA Repair in Human Bladder Cancer TSGH-8301 Cells

Jing-Gung Chung, Kung-Wen Lu, Shu-Fen Peng, 2019, AntiCancer Research.

A novel compound, NP-184, inhibits the vascular endothelial growth factor induced angiogenesis.

S. Kuo, C. Chung, Kuan-Ting Lin, 2010, European journal of pharmacology.

Tetrandrine Suppresses Human Brain Glioblastoma GBM 8401/luc2 Cell-Xenografted Subcutaneous Tumors in Nude Mice In Vivo

T. Hsia, Chao‐Lin Kuo, Fei-Ting Hsu, 2021, Molecules.

Inhibitory Effects of an Orally Active Thromboxane A2 Receptor Antagonist, nstpbp5185, on Atherosclerosis in ApoE-Deficient Mice

S. Kuo, J. Lien, Shiu‐Wen Huang, 2018, Thrombosis and Haemostasis.

Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives.

Hui-Yi Lin, Chi-Hung Huang, Yi-Chien Lin, 2013, European journal of medicinal chemistry.

Anthocyanins from black rice (Oryza sativa) promote immune responses in leukemia through enhancing phagocytosis of macrophages in vivo

M. Fan, Jing-Gung Chung, Hui-Yi Lin, 2017, Experimental and therapeutic medicine.

A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐angiogenesis effects by targeting VEGFR‐2 signalling

M. Hsu, C. Chung, J. Lien, 2019, British Journal of Pharmacology.

Allyl Isothiocyanate Induces DNA Damage and Impairs DNA Repair in Human Breast Cancer MCF-7 Cells

Po-Yuan Chen, T. Chiang, F. Chueh, 2021, AntiCancer Research.

Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase‐dependent pathways and associated with beclin‐1‐induced cell autophagy

Kuang-Chi Lai, Jing-Gung Chung, Shu-Jen Chang, 2017, Environmental toxicology.

Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.

Kuang-Chi Lai, Jing-Gung Chung, J. Lien, 2015, Anticancer research.

PW06 Triggered Fas-FADD to Induce Apoptotic Cell Death In Human Pancreatic Carcinoma MIA PaCa-2 Cells through the Activation of the Caspase-Mediated Pathway

P. Lyu, T. Hsia, Kuang-Chi Lai, 2023, Oxidative medicine and cellular longevity.

Solvent Effect of Dimethyl Sulfoxide on the Chemical Shifts of Phenyl Vinyl Ketones

Sheng-Chih Chen, S. Kuo, Li‐Jiau Huang, 2004 .

Ethyl 2-anilino-4-oxo-4,5-dihydrofuran-3-carboxylate exhibits anti-proliferative activity and induces apoptosis in promyelocytic leukemia HL-60 cells

Cheng-Wen Lin, H. Lai, W. Lin, 2020, Oncology letters.

Antioxidant Effects and Phytochemical Properties of Seven Taiwanese Cirsium Species Extracts

Chi-Rei Wu, Hui-Chi Huang, Hung-Chi Chang, 2021, Molecules.

Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways.

Jing-Gung Chung, Shu-Jen Chang, Y. Hsiao, 2015, Anticancer research.

Fisetin Inhibits Cell Proliferation through the Induction of G0/G1 Phase Arrest and Caspase-3-Mediated Apoptosis in Mouse Leukemia Cells.

M. Fan, Jing-Gung Chung, Shu-Fen Peng, 2019, The American journal of Chinese medicine.

Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells

F. Chueh, Shu-Fen Peng, Wen-Wen Huang, 2020, In Vivo.

Crude extract of Polygonum cuspidatum promotes immune responses in leukemic mice through enhancing phagocytosis of macrophage and natural killer cell activities in vivo.

Jing-Gung Chung, F. Chueh, J. Lien, 2015, In vivo.

Tetrandrine inhibits cell migration and invasion in human nasopharyngeal carcinoma NPC-TW 039 cells through inhibiting MAPK and RhoA signaling pathways.

T. Hsia, Po-Yuan Chen, F. Chueh, 2020, Journal of food biochemistry.

Kuang-Chi Lai, Jing-Gung Chung, Shu-Jen Chang, 2017, Environmental toxicology.

Bp5250 inhibits vascular endothelial growth factor-induced angiogenesis and HIF-1α expression on endothelial cells

S. Kuo, C. Chung, Kuan-Ting Lin, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pculin02H, a curcumin derivative, inhibits proliferation and clinical drug resistance of HER2-overexpressing cancer cells.

Chi-Tang Ho, S. Kuo, Tzong-Der Way, 2015, Chemico-biological interactions.

Molecular interaction of the antiviral compound CW-33 and its analogues with the NS2B-NS3 protease of the Japanese encephalitis virus

Cheng-Wen Lin, Jing Gao, J. Lien, 2019, International journal of molecular medicine.

PW06 suppresses cancer cell metastasis in human pancreatic carcinoma MIA PaCa‐2 cells via the inhibitions of p‐Akt/mTOR/NF‐κB and MMP2/MMP9 signaling pathways in vitro

Po-Yuan Chen, Kuang-Chi Lai, J. Lien, 2024, Environmental toxicology.

Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds.

S. Kuo, D. Lednicer, K. Lee, 1996, Journal of medicinal chemistry.