Y. Mitsuoka

发表

A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.

Yusuke Nakamura, K. Kusakabe, Y. Daigo, 2015, Bioorganic & medicinal chemistry.

A bridged nucleic acid, 2′,4′-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNACOC monomers and RNA-selective nucleic-acid recognition

Y. Hari, S. Obika, T. Imanishi, 2009, Nucleic acids research.

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure.

Y. Hari, S. Obika, H. Aoyama, 2016, Organic & biomolecular chemistry.

RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides.

Shin-ichiro Hori, Y. Mitsuoka, A. Kugimiya, 2019, Nucleic acid therapeutics.

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.

Y. Hari, S. Obika, Tsuyoshi Yamamoto, 2017, The Journal of organic chemistry.

Sulfonamide-bridged nucleic acid: synthesis, high RNA selective hybridization, and high nuclease resistance.

Y. Hari, S. Obika, Tsuyoshi Yamamoto, 2014, Organic letters.

Development of a novel nucleoside analogue with S-type sugar conformation: 2′-deoxy-trans-3′,4′-bridged nucleic acids

S. Obika, T. Imanishi, T. Osaki, 2007 .

Synthesis and properties of 2'-deoxy-trans-3',4'-BNA with S-Type sugar puckering

S. Obika, T. Imanishi, T. Kodama, 2009 .

Synthesis and properties of trans-3',4'-bridged nucleic acids having typical S-type sugar conformation.

S. Obika, T. Imanishi, T. Osaki, 2006, Journal of Organic Chemistry.

Synthesis and properties of a 2'-deoxy analogue of trans-3',4'-BNA with an S-type sugar conformation.

S. Obika, T. Imanishi, T. Kodama, 2007, Nucleic acids symposium series.

Synthesis of Novel 2′-Deoxy Type Trans-3′,4′-Bridged Nucleic Acid

S. Obika, T. Imanishi, T. Osaki, 2007, Nucleosides, nucleotides & nucleic acids.

Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction.

K. Kusakabe, Y. Kido, Shiho Yamamoto, 2021, European journal of medicinal chemistry.

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

K. Kusakabe, Y. Kido, T. Fukushima, 2018, Journal of medicinal chemistry.

Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure.

Y. Hari, S. Obika, H. Aoyama, 2016, Organic & biomolecular chemistry.