M. Chambers

发表

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

Discovery of ONO-8590580: a novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders.

A. Beresford, H. Habashita, A. Macleod, 2020, Bioorganic & medicinal chemistry letters.

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor α5 Subtype-Selective Inverse Agonist

A. D. Rodrigues, K. Gingrich, G. Dawson, 2009, Journal of Pharmacology and Experimental Therapeutics.

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-

A. D. Rodrigues, K. Gingrich, G. Dawson, 2009 .

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2013, ACS medicinal chemistry letters.

ENANTIOMERIC SEPARATION OF A SERIES OF 1,4-BENZODIAZEPIN-2-ONE CCK B RECEPTOR ANTAGONISTS BEARING ACIDIC SUBSTITUENTS BY CHIRAL HPLC

H. Verrier, A. Watt, D. Rathbone, 1999 .

Potent, selective, water-soluble benzodiazepine-based CCKB receptor antagonists that contain lipophilic carboxylate surrogates

V. Matassa, S. Freedman, S. Fletcher, 1995 .

L-708,474: The C5-cyclohexyl analogue of L-365,260, a selective high affinity ligand for the CCKB/gastrin receptor

V. Matassa, S. Freedman, S. Fletcher, 1993 .

Derives de benzodiazepine

V. Matassa, S. Fletcher, K. Moore, 1993 .

3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.

J. Atack, A. Macleod, A. Macaulay, 2004, Bioorganic & medicinal chemistry letters.

Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.

M. Shultz, Jonathan E. Grob, R. Tommasi, 2011, Bioorganic & medicinal chemistry letters.

Spiropiperidines as high-affinity, selective sigma ligands.

E. Wong, D. Middlemiss, D. Billington, 1992, Journal of medicinal chemistry.

Can relief of ring-strain in a cyclopropylmethyllithium drive the Brook rearrangement?

J. Clayden, M. Chambers, D. Watson, 2005 .

Rapid analogue synthesis of C-5 substituted 1,2,3-triazolo-[1,5-a]quinazolines

M. Chambers, Philip Jones, 2002 .

CCK-B antagonists in the control of anxiety and gastric acid secretion.

S. Fletcher, M. Chambers, 2000, Progress in medicinal chemistry.

N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.

J. Metzger, D. Macintyre, R. Hargreaves, 1996, Journal of medicinal chemistry.

β-Lactams or γ-lactams by 4-exo-trig or 5-endo-trig anionic cyclisation of lithiated acrylamide derivatives

M. Helliwell, J. Clayden, M. Chambers, 2003 .

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.

G. Dawson, J. Atack, H. Broughton, 2002, Journal of medicinal chemistry.

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.

D. Middlemiss, V. Matassa, M. Beer, 1993, Journal of medicinal chemistry.

Total Synthesis and Determination of the Absolute Configuration of Epibatidine

R. Ball, H. Verrier, S. Fletcher, 1994 .

The synthesis of (+)- and (–)-epibatidine

S. Fletcher, R. Baker, P. Mitchell, 1993 .

Mono- and dithionopeptide synthesis

David W. Brown, M. Chambers, M. M. Campbell, 1987 .

Asymmetric synthesis of 5,5-disubstituted thiotetronic acids using anallyl xanthate to dithiocarbonate rearrangement: total synthesis of(5S)-thiolactomycin with revision of the absolute configurationof the natural

E. J. Thomas, M. Chambers, E. Thomas, 1997 .

An asymmetric synthesis of thiotetronic acids using chirality transfer via an allyl xanthate-to-dithiocarbonate rearrangement. X-Ray crystal structure of (5R)-2,5-dihydro-4-hydroxy-5-methyl-3-phenyl-5-prop-1′-enyl-2-oxothiophene

David J. Williams, E. J. Thomas, M. Chambers, 1987 .

ONO-8590580, a Novel GABAA α5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models

S. Kaneko, S. Katsumata, M. Chambers, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Aldehyde oxidase and its contribution to the metabolism of a structurally novel, functionally selective GABAA α5-subtype inverse agonist

D. O'connor, M. Braun, A. Macleod, 2006, Xenobiotica; the fate of foreign compounds in biological systems.

3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.

V. Matassa, M. Beer, J. Stanton, 1999, Journal of medicinal chemistry.

Rapid Analogue Synthesis of C-5 Substituted 1,2,3-Triazolo[1,5-a]quinazolines.

M. Chambers, Philip Jones, 2003 .

Total synthesis of (5S)-thiolactomycin: revision of the absolute configuration of the natural product

E. J. Thomas, M. Chambers, E. Thomas, 1989 .

Total Synthesis of (5S)-Thiolactomycin (I): Revision of the Absolute Configuration of the Natural Product.

E. J. Thomas, M. Chambers, 1989 .

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

G. Dawson, J. Atack, D. O'connor, 2004, Journal of medicinal chemistry.

Non-covalent inhibitors of rhinovirus 3C protease.

P. Rawlins, A. Morley, K. Edman, 2011, Bioorganic & medicinal chemistry letters.

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

M. Rigby, K. Tsao, F. Murray, 2006, Bioorganic & medicinal chemistry letters.

Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

G. Dawson, J. Atack, H. Broughton, 2003 .

Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.

V. Birault, Joelle Le, G. Dixon, 2012, Bioorganic & medicinal chemistry letters.

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.

Desmond O'Connor, Robert Maxey, J. Atack, 2006, Bioorganic & medicinal chemistry letters.

3,4‐Dihydronaphthalen‐1(2H)‐ones: Novel Ligands for the Benzodiazepine Site of α5‐Containing GABAA Receptors.

J. Atack, A. Macleod, A. Macaulay, 2004 .