Xiaolin Zhang

发表

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases

M. Ahn, Dong-Wan Kim, J. Yang, 2016, Science Translational Medicine.

Differential Effects of Rifampin and Ketoconazole on the Blood and Liver Concentration of Atorvastatin in Wild-Type and Cyp3a and Oatp1a/b Knockout Mice

E. Plise, J. Cheong, J. Ly, 2014, Drug Metabolism and Disposition.

Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage

Jing‐Yan Han, Xiaojun Zhu, L. Zhang, 2017, Disease Models & Mechanisms.

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors.

M. Belvin, E. Bradley, M. Ultsch, 2013 .

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.

K. Varnäs, P. Johnström, Xiaolin Zhang, 2015, Journal of medicinal chemistry.

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma

L. Rangell, H. Phillips, H. Koeppen, 2016, Drug Metabolism and Disposition.

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

S. Sideris, Leslie B. Lee, K. Edgar, 2016, ACS medicinal chemistry letters.

Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression

Yi-long Wu, Jin-Ji Yang, Xue-Ning Yang, 2010, Molecular Cancer.

Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets

Shuqiong Fan, Lili Tang, Jiafu Ji, 2014, Genes, chromosomes & cancer.

Inhibiting Kinases in the CNS

Xiaolin Zhang, Kan Chen, H. Tsui, 2017 .

Oncogenic HER2 fusions in gastric cancer

J. Ji, Lianhai Zhang, G. Zhu, 2015, Journal of Translational Medicine.

Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

J. Shao, Q. Ji, Jie Du, 2014, Molecular Cancer.

Predictive Biomarkers and Personalized Medicine FGFR 2 Gene Ampli fi cation in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD 4547

J. Ji, Lianhai Zhang, E. Kilgour, 2013 .

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

K. Scearce-Levie, M. P. van der Brug, Xingrong Liu, 2012, Science Translational Medicine.

Individual serum bile acid profiling in rats aids in human risk assessment of drug‐induced liver injury due to BSEP inhibition

Y. Ran, L. Salphati, J. Tarrant, 2018, Toxicology and applied pharmacology.

Clock-controlled StAR’s expression and corticosterone production contribute to the endotoxemia immune response

Zhongsheng Sun, Huajing Teng, Yonglun Luo, 2015, Chronobiology international.

Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer

A. Eastman, D. Bates, E. Demidenko, 2016, Clinical Cancer Research.

A convenient method to measure blood-plasma concentration ratio using routine plasma collection in in vivo pharmacokinetic studies.

J. Cheong, L. Berezhkovskiy, Xiaolin Zhang, 2011, Journal of pharmaceutical sciences.

Supercritical fluid chromatography‐tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery

Jianshuang Wang, B. Dean, Xiaolin Zhang, 2019, Journal of pharmaceutical and biomedical analysis.

The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.

S. Sideris, Leslie B. Lee, K. Edgar, 2012, Journal of medicinal chemistry.

Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human

Leslie B. Lee, D. Sampath, E. Plise, 2012, Drug Metabolism and Disposition.

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human

E. Plise, L. Salphati, J. Halladay, 2011 .

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human.

E. Plise, L. Salphati, J. Halladay, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening.

Xingrong Liu, B. Liederer, C. Hop, 2013, Rapid communications in mass spectrometry : RCM.

Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse

J. Cheong, J. Ly, E. Chen, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier

J. Sarkaria, H. Phillips, S. Kharbanda, 2012, Clinical Cancer Research.

Role of P-Glycoprotein and Breast Cancer Resistance Protein-1 in the Brain Penetration and Brain Pharmacodynamic Activity of the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941

Leslie B. Lee, E. Plise, L. Salphati, 2010, Drug Metabolism and Disposition.

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model

X. Chu, M. Mezler, O. Langer, 2016, Molecular Pharmacology.

Open Access RESEARCH

Young Yang, Peter Suber, Yi-long Wu, 2010 .

Oncogenic HER2 fusions in gastric cancer

J. Ji, Lianhai Zhang, L. Tang, 2015, Journal of Translational Medicine.