M. Ledeboer

发表

Total synthesis and comparative evaluation of luzopeptin A-C and quinoxapeptin A-C

D. Boger, M. Ledeboer, M. Kume, 1999 .

Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs

F. Salituro, A. Fryer, D. Jacoby, 2013, PloS one.

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.

F. Salituro, S. Pazhanisamy, L. Swenson, 2009, Bioorganic & medicinal chemistry letters.

Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.

P. Charifson, Tiansheng Wang, E. Perola, 2015, Bioorganic & medicinal chemistry letters.

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.

J. Griffith, Tiansheng Wang, V. Damagnez, 2015, Journal of medicinal chemistry.

Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.

Maolin Yu, John F. Reilly, M. Beconi, 2019, ACS medicinal chemistry letters.

Total Synthesis of Luzopeptins A−C

D. Boger, M. Ledeboer, M. Kume, 1999 .

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.

F. Maltais, P. Charifson, Alice Tsai, 2017, ACS medicinal chemistry letters.

Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones.

K. A. Parker, M. Ledeboer, 1996, The Journal of organic chemistry.

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

S. Raunser, Oliver Hofnagel, F. Merino, 2020, bioRxiv.

A translational kidney organoid system bolsters human relevance of clinical development candidate

M. Emani, J. Harmange, P. Mundel, 2019, bioRxiv.

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.

F. Salituro, Hui-Sheng Huang, Edmund M. Harrington, 2015, Journal of medicinal chemistry.

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

M. Murcko, P. Charifson, A. Kwong, 2014, Antimicrobial Agents and Chemotherapy.

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.

M. Murcko, F. Maltais, P. Charifson, 2014, Journal of medicinal chemistry.

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

F. Salituro, Tiansheng Wang, A. Pierce, 2010, Bioorganic & medicinal chemistry letters.

A Novel Chemotype of Kinase Inhibitors

Tiansheng Wang, H. Zuccola, M. Ledeboer, 2009 .

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.

G. Bemis, F. Salituro, Edmund M. Harrington, 2009, Bioorganic & medicinal chemistry letters.

Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

M. Emani, J. Harmange, P. Mundel, 2022, Science advances.

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.

G. Bemis, F. Salituro, Edmund M. Harrington, 2009, Bioorganic & medicinal chemistry letters.

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.

F. Maltais, P. Charifson, Alice Tsai, 2017, ACS medicinal chemistry letters.

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.

M. Murcko, F. Maltais, P. Charifson, 2014, Journal of medicinal chemistry.