M. Kume

发表

Total synthesis and comparative evaluation of luzopeptin A-C and quinoxapeptin A-C

D. Boger, M. Ledeboer, M. Kume, 1999 .

Efficient Preparation of New Chiral Synthons Useful for (+)-Carbacyclin Synthesis by Utilizing Enzymatic Hydrolysis of Prochiral σ-Symmetric Diesters.

M. Ochiai, Y. Nagao, M. Kume, 1989 .

The 7α-methoxy substituent in cephem or oxacephem antibiotics enhances in vivo anti-Helicobacter felis activity in mice after oral administration

Yoshinao Kobayashi, K. Murakami, H. Nagata, 2000 .

Efficient and practical synthesis of 1⊝methylcarbapenems

H. Ishitobi, M. Kume, H. Ooka, 1997 .

ORALLY ACTIVE CEPHALOSPORINS

M. Kume, Y. Kimura, M. Nakano, 1993 .

Orally Active Cephalosporins. Part 1. Synthesis and Structure‐Activity Relationships of 7β‐(2‐(R)‐Amino‐2‐phenylacetamido)‐3‐(1H‐1,2,3‐ triazol‐4‐yl)alkylthiomethyl ‐3‐cephem‐4‐carboxylic Acid and Related Compounds

M. Kume, Y. Kimura, K. Motokawa, 1993 .

Orally active cephalosporins. III. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7 beta-[(Z)- 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-cephem-4 -carboxylic acids.

M. Kume, Y. Kimura, K. Motokawa, 1993, The Journal of antibiotics.

Total Synthesis of Luzopeptins A−C

D. Boger, M. Ledeboer, M. Kume, 1999 .

Novel and efficient synthesis of 1β-methylcarbapenems utilizing cyclization of hypervalent iodonium ylides

Y. Iso, M. Kume, T. Kubota, 1995 .

Efficient and Practical Synthesis of 1β‐Methylcarbapenems.

H. Ishitobi, M. Kume, H. Ooka, 1997 .

Remarkable Effect of D-Sorbitol on the Second Stage in the PLE-Catalyzed Hydrolyses of a σ-Symmetric Diester, cis-Cyclohex-4-ene-1,2-bis(methyl acetate)

Y. Nagao, M. Kume, Toshiaki Tohjo, 1992 .

Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.

H. Kai, M. Kume, Shoichi Yamamoto, 2017, Bioorganic & medicinal chemistry letters.

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization.

H. Kai, M. Kume, Shoichi Yamamoto, 2019, Bioorganic & medicinal chemistry letters.

Orally active cephalosporins. II. Synthesis and structure-activity relationships of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-cephalospori ns with 1,2,3-triazole in C-3 side chain.

M. Kume, Y. Kimura, M. Nakano, 1993, The Journal of antibiotics.

Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects.

H. Kai, T. Kanemasa, M. Kume, 2019, Bioorganic & medicinal chemistry letters.

Enzymatic Hydrolyses of the σ-Symmetric Dicarboxylic Diesters Bearing a Sulfinyl Group as the Prochiral Center

S. Miyauchi, Y. Nagao, S. Sano, 1994 .

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening.

Yoshikazu Tanaka, H. Kai, T. Kameyama, 2017, Bioorganic & medicinal chemistry letters.