Xi-ming Yang

发表

Dose-response relationships of the protective and antiprotective effects of acute ethanol exposure in isolated rabbit hearts.

Michael V. Cohen, J. Downey, M. Krenz, 2002, Heart disease.

Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning’s success

Michael V. Cohen, J. Downey, Xi-ming Yang, 2008, Basic Research in Cardiology.

Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies.

Michael V. Cohen, J. Downey, Xi-ming Yang, 2006, Cardiovascular research.

Attenuation of S-T Segment elevation during repetitive coronary occlusions truly reflects the protection of Ischemic preconditioning and is not an epiphenomenon

J. Downey, M. Cohen, Xi-ming Yang, 1997, Basic Research in Cardiology.

P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

Michael V. Cohen, J. Downey, G. Grover, 2003, Journal of molecular and cellular cardiology.

CGX-1051, A Peptide from Conus Snail Venom, Attenuates Infarction in Rabbit Hearts When Administered at Reperfusion

Michael V. Cohen, J. Downey, Guang S. Liu, 2003, Journal of cardiovascular pharmacology.

Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity

Michael V. Cohen, J. Downey, Xiulan Yang, 2011, Basic Research in Cardiology.

Platelet P2Y12 Blockers Confer Direct Postconditioning-Like Protection in Reperfused Rabbit Hearts

Michael V. Cohen, J. Downey, Yongge Liu, 2013, Journal of cardiovascular pharmacology and therapeutics.

S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning.

Michael V. Cohen, J. Downey, S. Critz, 1999, American journal of physiology. Heart and circulatory physiology.

The Highly Selective Caspase-1 Inhibitor VX-765 Provides Additive Protection Against Myocardial Infarction in Rat Hearts When Combined With a Platelet Inhibitor

J. Downey, D. Alvarez, J. Audia, 2017, Journal of cardiovascular pharmacology and therapeutics.

Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart.

J. Downey, Xi-ming Yang, M. Cohen, 1999, American journal of physiology. Heart and circulatory physiology.

Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator

J. Downey, E. Iliodromitis, D. Kremastinos, 2007, Basic Research in Cardiology.

Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation

J. Downey, D. Yellon, R. Bell, 2016, Cardiovascular Drugs and Therapy.

A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin

J. Downey, T. Rich, Xiulan Yang, 2011, British journal of pharmacology.

Attenuation of infarction in cynomolgus monkeys: preconditioning and postconditioning

J. Downey, Yongge Liu, N. Tandon, 2009, Basic Research in Cardiology.

Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion.

J. Downey, S. Critz, T. Krahn, 2007, Journal of molecular and cellular cardiology.

Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.

J. Downey, S. Philipp, Xi-ming Yang, 2006, Cardiovascular research.

NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.

J. Downey, T. Krieg, Xi-ming Yang, 2004, Journal of molecular and cellular cardiology.

Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.

J. Downey, S. Critz, T. Krieg, 2004, American journal of physiology. Heart and circulatory physiology.

Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts

J. Downey, S. Philipp, Xi-ming Yang, 2006, Basic Research in Cardiology.

Cardioprotective PKG-independent NO signaling at reperfusion.

J. Downey, Yanping Liu, Xi-ming Yang, 2010, American journal of physiology. Heart and circulatory physiology.

Opening of Mitochondrial KATP Channels Triggers the Preconditioned State by Generating Free Radicals

J. Downey, S. Critz, M. Cohen, 2000, Circulation research.

The pH Hypothesis of Postconditioning: Staccato Reperfusion Reintroduces Oxygen and Perpetuates Myocardial Acidosis

J. Downey, Xi-ming Yang, M. Cohen, 2007, Circulation.

Postconditioning’s protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3–kinase and guanylyl cyclase activation

J. Downey, S. Philipp, Xi-ming Yang, 2004, Basic Research in Cardiology.

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

J. Downey, D. Alvarez, J. Audia, 2018, Basic Research in Cardiology.

Vascular endothelial growth factor gene expression regulated by protein kinase C pathway in endothelial cells during hypoxia.

Zhihong Zhou, Zhi Zhou, Xi-ming Yang, 2002, Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering.

Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity

J. Downey, Sarah L Sayner, J. Audia, 2023, International journal of molecular sciences.

Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.

J. Downey, T. Krieg, Xi-ming Yang, 2004, Journal of the American College of Cardiology.

Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial KATP Channels

J. Downey, G. Heusch, Xi-ming Yang, 2001, Circulation research.

Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism.

J. Downey, T. Lincoln, S. Critz, 2004, American journal of physiology. Heart and circulatory physiology.

AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts

J. Downey, T. Krieg, Xiulan Yang, 2009, Basic Research in Cardiology.

Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C.

J. Downey, A. Kuno, Yanping Liu, 2008, American journal of physiology. Heart and circulatory physiology.

Two Classes of Anti-Platelet Drugs Reduce Anatomical Infarct Size in Monkey Hearts

J. Downey, Yongge Liu, N. Tandon, 2013, Cardiovascular Drugs and Therapy.

Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion

J. Downey, G. Wilson, M. Gillespie, 2015, Basic Research in Cardiology.

Ticagrelor Does Not Protect Isolated Rat Hearts, Thus Clouding Its Proposed Cardioprotective Role Through ENT 1 in Heart Tissue

J. Downey, D. Alvarez, J. Audia, 2019, Journal of cardiovascular pharmacology and therapeutics.

Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart

J. Downey, Xi-ming Yang, Lin Cui, 2013, Cardiovascular Drugs and Therapy.

Feasibility of using thermal response to Ka band millimeter wave heating to assess skin blood flow

J. Downey, D. Nelson, S. Leavesley, 2018, Physiological measurement.

BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts.

J. Downey, S. Felix, J. Stasch, 2009, European heart journal.

A new animal model of controlled coronary artery occlusion in conscious rabbits.

J. Downey, Yongge Liu, M. Cohen, 1994, Cardiovascular research.

Favorable remodeling enhances recovery of regional myocardial function in the weeks after infarction in ischemically preconditioned hearts.

J. Downey, M. Cohen, G. Heusch, 2000, Circulation.

Role of bradykinin in protection of ischemic preconditioning in rabbit hearts.

J. Downey, Yongge Liu, M. Cohen, 1995, Circulation research.

Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing.

J. Downey, Yongge Liu, M. Cohen, 1994, The American journal of physiology.

Limitation of infarct size in rabbit hearts by the novel adenosine receptor agonist AMP 579 administered at reperfusion.

J. Downey, M. Cohen, G. Heusch, 2000, Journal of molecular and cellular cardiology.

Infarct limitation of the second window of protection in a conscious rabbit model.

J. Downey, D. Yellon, M. Cohen, 1996, Cardiovascular research.

Protection of ischemic preconditioning is dependent upon a critical timing sequence of protein kinase C activation.

J. Downey, M. Cohen, H. Sato, 1997, Journal of molecular and cellular cardiology.

Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits.

J. Downey, M. Cohen, K. Mullane, 1995, Cardiovascular research.

Protective and anti-protective effects of acute ethanol exposure have similar thresholds in isolated rabbit hearts

J. Downey, M. Krenz, Xi-ming Yang, 2001 .

Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning.

J. Downey, M. Cohen, X. Yang, 1994, Circulation research.

A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin

J. Downey, T. Rich, Xiulan Yang, 2011, British journal of pharmacology.

Acute ethanol exposure fails to elicit preconditioning-like protection in in situ rabbit hearts because of its continued presence during ischemia.

J. Downey, C. Baines, M. Cohen, 2001, Journal of the American College of Cardiology.

BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts.

J. Downey, S. Felix, J. Stasch, 2009, European heart journal.