Shigeto Hirayama

发表

Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway

Y. Higami, Y. Uezono, M. Narita, 2021, Cells.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.

H. Nagase, Shigeto Hirayama, H. Fujii, 2012, Bioorganic & medicinal chemistry.

Usefulness of Olanzapine as an Adjunct to Opioid Treatment and for the Treatment of Neuropathic Pain

M. Rahmadi, M. Narita, Akira Yamashita, 2012, Anesthesiology.

Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives

H. Gouda, Daichi Hayakawa, Shigeto Hirayama, 2020, Molecules.

Discovery of δ opioid receptor full agonists lacking a basic nitrogen atom and their antidepressant-like effects.

Daisuke Yamada, A. Saitoh, Shigeto Hirayama, 2020, Bioorganic & medicinal chemistry letters.

Development of Novel δ Opioid Receptor Inverse Agonists without a Basic Nitrogen Atom and Their Antitussive Effects in Mice.

H. Ikeda, J. Kamei, Shigeto Hirayama, 2019, ACS chemical neuroscience.

Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.

H. Nagase, Toshihiro Takahashi, Shigeto Hirayama, 2017, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Yurie Watanabe, M. Yanagisawa, D. Kuroda, 2017, Journal of medicinal chemistry.

Synthesis and evaluation of novel opioid ligands with a C-homomorphinan skeleton.

K. Nagai, Shigeto Hirayama, H. Fujii, 2016, Bioorganic & medicinal chemistry.

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2015, Bioorganic & medicinal chemistry letters.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

H. Nagase, T. Kanemasa, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry.

Opioid Kappa Receptor Selective Agonist TRK-820 (Nalfurafine Hydrochloride)

H. Nagase, Shigeto Hirayama, H. Fujii, 2012 .

Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT

S. Shioda, M. Rahmadi, Tsutomu Suzuki, 2016, Psychopharmacology.

Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice

Tsutomu Suzuki, Tomohisa Mori, D. Masukawa, 2020, Behavioural Brain Research.

Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.

S. Hirono, H. Gouda, Shigeto Hirayama, 2014, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Upregulation of bradykinin receptors is implicated in the pain associated with caerulein‐induced acute pancreatitis

M. Narita, S. Imai, N. Kuzumaki, 2011, Synapse.

Visible-Light-Induced Synthesis of Imidazolidines Through Formal [3+2] Cycloaddition of Aromatic Imines with N,N,N',N'-Tetramethyldiaminomethane

M. Hashimoto, Fumika Karaki, N. Sato, 2022, SSRN Electronic Journal.

Synthesis of 1,2,5‐Oxadiazinane Derivatives by Photochemical Cycloaddition of Nitrones with Diaminomethanes

K. Tokunaga, H. Suga, R. Kato, 2020 .

Synthesis of (-)-homogalanthamine from naltrexone.

H. Tomoda, H. Nagase, J. Inokoshi, 2011, Journal of Organic Chemistry.

A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives

Y. Uezono, N. Ishibashi, Fumika Karaki, 2019, ChemMedChem.

Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies.

N. Yamaotsu, S. Hirono, H. Nagase, 2012, Chemical & pharmaceutical bulletin.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

Y. Nagumo, H. Nagase, A. Saitoh, 2015, Bioorganic & medicinal chemistry.

Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways

Y. Uezono, K. Yamaguchi, M. Iseki, 2022, Molecules.

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.

N. Yamaotsu, S. Hirono, N. Wada, 2014, Bioorganic & Medicinal Chemistry Letters.

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

N. Wada, H. Nagase, Shigeto Hirayama, 2013, Bioorganic & medicinal chemistry letters.

Rearrangement of 4,5α-epoxymorphinan derivatives with carbamoylepoxy rings provide novel oxazatricyclodecane structures

H. Nagase, Shigeto Hirayama, H. Fujii, 2011 .

Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT

S. Shioda, M. Rahmadi, Tsutomu Suzuki, 2016, Psychopharmacology.

Identification of a Putative β‐Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR)

Y. Uezono, Fumika Karaki, N. Sato, 2021, ChemMedChem.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator.

N. Sata, Y. Ueta, Y. Uezono, 2018, Journal of pharmacological sciences.

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & Medicinal Chemistry Letters.

Investigation of Beckett-Casy model 3: synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology.

S. Hirono, H. Gouda, H. Nagase, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.

H. Nagase, Shigeto Hirayama, H. Fujii, 2012, Bioorganic & medicinal chemistry letters.

Delta Opioid Receptor Inverse Agonists and Their in vivo Pharmacological Effects.

Shigeto Hirayama, H. Fujii, 2020, Current topics in medicinal chemistry.

Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration.

T. Kanda, H. Nagase, Toshihiro Takahashi, 2017, Bioorganic & medicinal chemistry letters.

Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors.

S. Hirono, H. Gouda, H. Nagase, 2015, Bioorganic & medicinal chemistry.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).

N. Wada, H. Nagase, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).

N. Wada, H. Nagase, Mayumi Nakajima, 2011, Bioorganic & medicinal chemistry letters.

Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors.

H. Gouda, H. Nagase, Shigeto Hirayama, 2021, Bioorganic & medicinal chemistry.

Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.

N. Wada, H. Nagase, Shigeto Hirayama, 2014, ACS medicinal chemistry letters.

Synthesis of a Novel Universal Opioid Receptor Agonist with the 1,3,5‐Trioxazatriquinane Skeleton and Its Pharmacologies.

N. Yamaotsu, S. Hirono, N. Wada, 2015 .

Effects of mirtazapine on sleep disturbance under neuropathic pain‐like state

E. Inada, M. Narita, Akira Yamashita, 2012, Synapse.

Discovery of δ Opioid Receptor Full Inverse Agonists and Their Effects on Restraint Stress-Induced Cognitive Impairment in Mice.

M. Tanabe, Shigeto Hirayama, H. Fujii, 2019, ACS chemical neuroscience.

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.

H. Nagase, Satomi Imaide, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry letters.

Visible-Light-Induced Synthesis of 1,2,3,4-Tetrahydroquinolines via Formal [4+2] Cycloaddition of Acyclic α,β-Unsaturated Amides and Imides with N,N-Dialkylanilines.

K. Tokunaga, M. Hashimoto, Fumika Karaki, 2020, Chemistry.

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & medicinal chemistry letters.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2015, Bioorganic & medicinal chemistry letters.

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

H. Nagase, T. Kanemasa, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry.

Visible-Light-Induced Formal [3+2] Cycloaddition of α, β-Unsaturated Imides or Amide with N,N,N',N'-Tetramethyldiaminomethane for the Synthesis of 4-Alkyl- and 4-Aryl-1-methyl-2-pyrrolidinones

M. Hashimoto, Fumika Karaki, Shun‐ichi Nagao, 2022, HETEROCYCLES.

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol

Y. Uezono, Fumika Karaki, Shigeto Hirayama, 2023, Molecules.