M. Löffler

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HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases

P. Eyer, F. Worek, U. Spöhrer, 2005, Archives of Toxicology.

Simultaneous analysis of mitochondrial activity and DNA content in ehrlich ascites tumor cells by dual parameter flow cytometry

T. Hämmerle, M. Löffler, 2004, Histochemistry.

Differential susceptibility of dihydroorotate dehydrogenase/oxidase to Brequinar Sodium (NSC 368 390) in vitro.

M. Löffler, G. Lakaschus, 1992, Biochemical pharmacology.

Dihydroorotate Dehydrogenase mRNA and Protein Expression Analysis in Normal and Drug‐Resistant Cells

L. Konrad, W. Knecht, M. Löffler, 2004, Nucleosides, nucleotides & nucleic acids.

The "anti-pyrimidine effect" of hypoxia and brequinar sodium (NSC 368390) is of consequence for tumor cell growth.

M. Löffler, 1992, Biochemical pharmacology.

The biosynthetic pathway of pyrimidine (deoxy)nucleotides: a sensor of oxygen tension necessary for maintaining cell proliferation?

M. Löffler, Monika Löffler, 1989, Experimental cell research.

Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase.

R. Lill, K. Diekert, W. Knecht, 2000, European journal of biochemistry.

Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide.

C. Beuneu, G. Lemaire, M. Löffler, 2000, Free radical biology & medicine.

Region-Specific Distribution of Dihydroorotate Dehydrogenase in the Rat Central Nervous System Points to Pyrimidine De Novo Synthesis in Neurons

M. Schäfer, M. Löffler, C. M. Schaefer, 2010, Nucleosides, nucleotides & nucleic acids.

Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria

G. Schuster, M. Löffler, Elisabeth Wegerle, 1996, Histochemistry and Cell Biology.

Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides

G. Schuster, M. Löffler, J. Jöckel, 2004, Molecular and Cellular Biochemistry.

KATP channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart

J. Daut, U. Brandt, P. Hanley, 2002, The Journal of physiology.

Lipogenesis in Ehrlich ascites tumor cells under anaerobic culture conditions

M. Löffler, F. Schneider, 1979, Journal of Cancer Research and Clinical Oncology.

Evidence from in vitro studies that dihydroorotate dehydrogenase may be a source of toxic oxygen species.

M. Löffler, G. Lakaschus, H. Krüger, 1991, Advances in experimental medicine and biology.

Pyrimidine pathways in health and disease.

H. Simmonds, L. Fairbanks, A. Marinaki, 2005, Trends in molecular medicine.

Pyrimidine Biosynthesis and Degradation (Catabolism)

M. Löffler, E. Zameitat, 2013 .

Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa.

Dylan M Glubb, J. Lucocq, M. Löffler, 2002, Reproduction.

On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency.

M. Löffler, 1980, European journal of biochemistry.

The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman.

L. D. de Jong, J. Langenberg, I. Hagedorn, 1989, Biochemical pharmacology.

Characterization of the deoxynucleoside-dependent reversal of hypoxia-induced inhibition of cell cycle progression in Ehrlich ascites tumor cells.

M. Löffler, 1985, European journal of cell biology.

Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis.

E. Carrey, M. Löffler, E. Zameitat, 2015, Journal of genetics and genomics = Yi chuan xue bao.

W. Knecht, M. Löffler, 1998, Biochemical pharmacology.

New perspectives on the roles of pyrimidines in the central nervous system

E. Carrey, M. Löffler, E. Zameitat, 2018, Nucleosides, nucleotides & nucleic acids.

Immunocytochemical detection of mitochondrial dihydroorotate dehydrogenase in human spermatozoa.

E. Hinsch, M. Löffler, C. Dietz, 2000, International journal of andrology.

Orotate (orotic acid): An essential and versatile molecule

E. Carrey, M. Löffler, E. Zameitat, 2016, Nucleosides, nucleotides & nucleic acids.

Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro.

W. Knecht, A. Ullrich, M. Löffler, 2002, Insect biochemistry and molecular biology.

Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?

W. Knecht, A. Ullrich, M. Löffler, 2001, European journal of biochemistry.

Redoxal as a new leadstructure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism

W. Knecht, M. Löffler, 2000, FEBS letters.

Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.

W. Knecht, M. Löffler, M. Fries, 1998, Protein expression and purification.

Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells.

W. Knecht, S. Gonski, M. Löffler, 1997, Protein expression and purification.

Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme.

B. Kirschbaum, W. Knecht, S. Gonski, 1996, European journal of biochemistry.

A mimicked in-situ remediation study of metal-contaminated soils with emphasis on cadmium and lead

Monika Löffler, Michel Mench, M. Mench, 1994 .

Influence of bromoacetylsulfanilic acid and bromoacetylaminoisophthalic acid on sulfhydryl groups of ehrlich ascites tumor cells

G. Niebch, M. Löffler, 1976, FEBS letters.

Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.

W. Knecht, M. Löffler, J. Henseling, 2000, Chemico-biological interactions.

Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues.

A. Pierik, M. Löffler, K. Zocher, 2007, FEMS yeast research.

Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides.

G. Schuster, M. Löffler, J. Jöckel, 1997 .

A cytokinetic approach to determine the range of O2‐dependence of pyrimidine(deoxy)nucleotide biosynthesis relevant for cell proliferation

M. Löffler, 1992, Cell proliferation.

Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.

Manuel F. Garavito, M. Huynh, V. Carruthers, 2012, Molecular and biochemical parasitology.

Uridine, but not cytidine can sustain growth of Ehrlich ascites tumor cells in glucose-deprived medium with altered proliferation kinetics.

M. Löffler, F. Schneider, W. Linker, 1985, European journal of cell biology.

The pathway to pyrimidines: The essential focus on dihydroorotate dehydrogenase, the mitochondrial enzyme coupled to the respiratory chain

W. Knecht, E. Carrey, M. Löffler, 2020, Nucleosides, nucleotides & nucleic acids.

Separation ofN-carbamoyl aspartate andl-dihydroorotate from serum by high-performance liquid chromatography with fluorimetric detection

M. Löffler, M. Hayek-Ouassini, J. Henseling, 2002 .

Essential Role of Mitochondria in Pyrimidine Metabolism

E. Carrey, M. Löffler, E. Zameitat, 2015 .

Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts

J. Piškur, C. Neuvéglise, W. Knecht, 2004, Molecular Genetics and Genomics.

Functional Expression of Human Dihydroorotate Dehydrogenase (DHODH) in pyr4 Mutants of Ustilago maydis Allows Target Validation of DHODH Inhibitors In Vivo

M. Bölker, M. Löffler, G. Freymark, 2007, Applied and Environmental Microbiology.

Analysis of pyrimidine synthesis "de novo" intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometry.

A. V. van Kuilenburg, H. van Lenthe, M. Löffler, 2004, Clinical chemistry.

Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans

J. Piškur, W. Knecht, Z. Gojkovic, 2006, The FEBS journal.

The effect of glucosone on the proliferation and energy metabolism of in vitro grown Ehrlich ascites tumor cells.

K. Reiffen, M. Löffler, F. Schneider, 1981, Zeitschrift fur Naturforschung. Section C, Biosciences.

Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria.

B. Wendt, M. Löffler, J. Jöckel, 1998, Biochemical pharmacology.

Restimulation of cell cycle progression by hypoxic tumour cells with deoxynucleosides requires ppm oxygen tension.

M. Löffler, 1987, Experimental cell research.

Towards a further understanding of the growth-inhibiting action of oxygen deficiency. Evaluation of the effect of antimycin on proliferating Ehrlich ascites tumour cells.

M. Löffler, 1985, Experimental cell research.

Deoxycytidylate shortage is a cause of G1 arrest of ascites tumor cells under oxygen deficiency

H. Follmann, M. Löffler, G. Schimpff-Weiland, 1983, FEBS letters.

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane‐associated N‐terminal domain

E. Johansson, S. Larsen, J. Le Nours, 2004, Protein science : a publication of the Protein Society.

Phytophthora infestans Dihydroorotate Dehydrogenase Is a Potential Target for Chemical Control – A Comparison With the Enzyme From Solanum tuberosum

Manuel F. Garavito, S. Restrepo, H. Judelson, 2019, Front. Microbiol..

Two different dihydroorotate dehydrogenases from yeast Saccharomyces kluyveri

J. Piškur, W. Knecht, M. Löffler, 2004, FEBS letters.

Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes

J. Piškur, W. Knecht, A. Ullrich, 2002, FEBS letters.

Synthesis of β-hydroxy-propenamide derivatives and the inhibition of human dihydroorotate dehydrogenase

T. Kim, M. Löffler, Hye-Sun Na, 2003, Archives of pharmacal research.

Dihydroorotate dehydrogenase. Profile of a novel target for antiproliferative and immunosuppressive drugs.

W. Knecht, M. Löffler, A. Klein, 1997, Advances in experimental medicine and biology.

Anaerobiosis and oxygen recovery: Changes in cell cycle distribution of ehrlich ascites tumor cells grown in vitro

M. Löffler, F. Schneider, Stefan Postius, 1978, Virchows Archiv. B, Cell pathology.

The effect of SH‐blocking agents on the p‐nitrophenylphosphatase activity of intact ehrlich ascites tumor cells

M. Löffler, F. Schneider, 1975, FEBS letters.

Gene Expression of Enzymes Required for the De Novo Synthesis and Degradation of Pyrimidines in Rat Peripheral Tissues and Brain

M. Schäfer, J. Gerlach, M. Löffler, 2011, Nucleosides, nucleotides & nucleic acids.

Two different dihydroorotate dehydrogenases from yeast Saccharomyces kluyveri

J. Piškur, W. Knecht, M. Löffler, 2004, FEBS letters.

Anti-peptide immunoglobulins from rabbit and chicken eggs recognise recombinant human dihydroorotate dehydrogenase and a 44-kDa protein from rat liver mitochondria.

W. Knecht, M. Löffler, M. Minet, 1996, European journal of biochemistry.

Localization of dihydroorotate oxidase in myocardium and kidney cortex of the rat

S. Angermüller, M. Löffler, 1995, Histochemistry and Cell Biology.

Increased level of histone H1(0) messenger RNA in hypoxic Ehrlich ascites tumor cells.

D. Doenecke, H. Bouterfa, M. Löffler, 1990, Experimental cell research.

Cytokinetic studies on the switch from glucose to uridine metabolism, and vice versa, of Ehrlich ascites tumour cells in vitro

M. Löffler, F. Schneider, A. Wenzel, 1987, Cell and tissue kinetics.