H. O'Dowd

发表

N- and C-terminal modifications of negamycin.

Sampathkumar Anandan, D. Patel, C. Hackbarth, 2003, Bioorganic & medicinal chemistry letters.

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1.

Kevin J. Gagnon, F. Maltais, P. Charifson, 2021, Journal of medicinal chemistry.

An asymmetric synthesis of (2S,5S)-5-substituted azepane-2-carboxylate derivatives.

K. Farley, D. Wishka, Brian Samas, 2011, The Journal of organic chemistry.

Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

P. Charifson, D. Nicolau, B. Hanzelka, 2015, ACS medicinal chemistry letters.

7. Lincosamide Antibacterials

A. Erwin, H. O'Dowd, J. G. Lewis, 2014 .

Conformationally restricted analogs of deoxynegamycin.

Shihai Gu, Sampathkumar Anandan, D. Patel, 2004, Bioorganic & medicinal chemistry letters.

Novel 6-position modified 1-thioalkyl-lincosamines

M. Gordeev, H. O'Dowd, J. G. Lewis, 2008 .

Antimalarial artemisinin analogs. Synthesis via chemoselective CC bond formation and preliminary biological evaluation

T. Shapiro, G. Posner, P. Ploypradith, 1999 .

Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).

J. Griffith, V. Damagnez, S. Mahajan, 2018, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones.

P. Charifson, Tiansheng Wang, E. Perola, 2012, Bioorganic & medicinal chemistry letters.

Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.

P. Charifson, T. Grossman, Tiansheng Wang, 2014, Journal of medicinal chemistry.

Preparation of tetra-Boc-protected polymyxin B nonapeptide

P. Margolis, B. Kim, H. O'Dowd, 2007 .

Antimalarial sulfide, sulfone, and sulfonamide trioxanes.

T. Shapiro, G. Posner, M. Krasavin, 2000, Bioorganic & medicinal chemistry.

Antimalarial sulfone trioxanes

J. Cumming, T. Shapiro, G. Posner, 1998 .

Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives.

H. O'Dowd, J. Cochran, Seth A Freedman, 2022, Organic letters.

Novel antibacterial azetidine lincosamides.

Wen Wang, J. Trias, M. Gordeev, 2008, Bioorganic & medicinal chemistry letters.

Antimalarial cyclic peroxy ketals.

J. Cumming, T. Shapiro, G. Posner, 1998, Journal of Medicinal Chemistry.

Synthesis of a 6-Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3-Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization.

A. Aronov, H. O'Dowd, Philip N. Collier, 2018, ACS medicinal chemistry letters.

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

T. Shapiro, T. Kensler, S. Woo, 1999, Journal of medicinal chemistry.

Enantioselective synthesis of N1999A2.

Brad M. Rosen, A. Myers, H. O'Dowd, 2006, Journal of the American Chemical Society.