D. Puleston

发表

T cell senescence is thought to contribute to immune function decline, but the pathways that mediate senescence in these cells are not clear. Here, we evaluated T cell populations from healthy volunteers and determined that human CD8

S. J. Griffiths, S. Tooze, A. Lanna, 2014 .

Autophagy is a critical regulator of memory CD8+ T cell formation

P. Klenerman, V. Cerundolo, I. Panse, 2014, eLife.

Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway

A. Regev, N. Yosef, Allon Wagner, 2020, bioRxiv.

Autophagy Controls Acquisition of Aging Features in Macrophages

D. Ferguson, M. Veldhoen, V. Cerundolo, 2015, Journal of Innate Immunity.

Techniques for the Detection of Autophagy in Primary Mammalian Cells.

S. Chittaranjan, S. Gorski, N. Ktistakis, 2015, Cold Spring Harbor protocols.

Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells

L. Jostins, C. Behrends, S. Sanderson, 2021, bioRxiv.

Ancillary Activity: Beyond Core Metabolism in Immune Cells.

E. Pearce, Erika L. Pearce, M. Villa, 2017, Cell metabolism.

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation

L. Jostins, R. Fischer, Svenja Hester, 2022, Nature Communications.

Essential role for autophagy during invariant NKT cell development

G. Besra, V. Cerundolo, A. Simon, 2014, Proceedings of the National Academy of Sciences.

An LKB1–mitochondria axis controls TH17 effector function

Joerg M. Buescher, T. Jenuwein, D. O’Sullivan, 2022, Nature.

Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

K. Keshari, Rachel Chirayil, Justin S. A. Perry, 2022, bioRxiv.

The Role of Reactive Oxygen Species in Oxidative-Induced Neoplastic Transformation

D. Puleston, 2009 .

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments.

K. Keshari, Rachel Chirayil, Justin S. A. Perry, 2022, Cell metabolism.

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy

C. Bryant, A. Simon, H. Bayes, 2015, Autophagy.

Phosphoinositide acyl chain saturation drives CD8^+ effector T cell signaling and function

Joerg M. Buescher, Liang Zhao, Jonathan D. Curtis, 2023, Nature Immunology.

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

A. Regev, N. Yosef, Allon Wagner, 2021, Cell.

Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection.

C. Bryant, A. Simon, H. Bayes, 2014, Cell host & microbe.

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development

T. Höfer, T. Korn, M. Klingenspor, 2023, Nature Immunology.

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

E. Pearce, K. Grzes, M. Corrado, 2019, Cell metabolism.

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

Joerg M. Buescher, D. Green, N. Yosef, 2021, Cell.

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Joerg M. Buescher, S. Austin, S. Balabanov, 2019, Cell metabolism.

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells.

S. J. Griffiths, S. Tooze, A. Lanna, 2014, The Journal of clinical investigation.

p 38 signaling inhibits mTORC 1-independent autophagy in senescent human CD 8 + T cells

S. J. Griffiths, S. Tooze, A. Lanna, 2014 .

Polyamine metabolism regulates the T cell epigenome through hypusination

Joerg M. Buescher, D. Green, N. Yosef, 2020, bioRxiv.

Fever supports CD8+ effector T cell responses by promoting mitochondrial translation

M. Buck, Jonathan D. Curtis, E. Pearce, 2021, Proceedings of the National Academy of Sciences.

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

D. Ferguson, B. Kessler, M. MacFarlane, 2015, Cell Death Discovery.

New roles for autophagy and spermidine in T cells

A. Simon, D. Puleston, 2015, Microbial cell.

Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy

Joerg M. Buescher, Jonathan D. Curtis, E. Pearce, 2020, Nature Metabolism.

Detection of Mitochondrial Mass, Damage, and Reactive Oxygen Species by Flow Cytometry.

D. Puleston, Daniel J. Puleston, 2015, Cold Spring Harbor protocols.

Autophagy and Immune Senescence.

A. Simon, Hanlin Zhang, D. Puleston, 2016, Trends in molecular medicine.

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

Joerg M. Buescher, E. Pearce, B. Kelly, 2019, Nature Immunology.

Autophagy in the immune system

A. Simon, D. Puleston, Daniel J. Puleston, 2013, Immunology.

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

Joerg M. Buescher, E. Pearce, B. Kelly, 2019, Nature Immunology.

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

Joerg M. Buescher, E. Pearce, K. Grzes, 2023, bioRxiv.

Appetite for Arginine: Metabolic Control of Macrophage Hunger.

Erika L. Pearce, D. Puleston, 2020, Cell metabolism.

A metabolic vulnerability of pancreatic cancer

D. Puleston, 2023, Nature.