J. Somerville

发表

CD28 ligation increases macrophage suppression of T-cell proliferation

A. Sharpe, M. Kozlowski, D. Silberman, 2012, Cellular and Molecular Immunology.

Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.

David S. Nirschl, David S Nirschl, A. Doweyko, 2013, Bioorganic & medicinal chemistry letters.

Multiple binding sites of carboxypeptidase B: the evaluation of dissociation constants by quantitative affinity chromatography.

B. Dunn, J. Danner, J. Somerville, 1979, Biochemistry.

Regulation of glutamine synthetase II activity in Rhizobium meliloti 104A14

R. Shatters, M. Kahn, J. Somerville, 1989, Journal of bacteriology.

Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to beta-lactamase.

H. P. Fell, D. Kerr, H. Svensson, 1993, Cancer research.

PHA eludes macrophage suppression to activate CD8+ T cells.

N. Goldman, J. Somerville, J. Riggs, 2019, Immunobiology.

Sulfated etoposide and nitrogen mustard prodrugs and their activation by streptomyces arylsulfatase

D. Lowe, P. Senter, V. M. Vrudhula, 1995 .

Core exploration in optimization of chemokine receptor CCR4 antagonists.

K. McIntyre, M. Poss, Wayne Vaccaro, 2007, Bioorganic & medicinal chemistry letters.

P fimbriae‐dependent, lipopolysaccharide‐independent activation of epithelial cytokine responses

L. Hang, C. Svanborg, M. Hedlund, 1999, Molecular microbiology.

Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide

Michael G. Yang, Michael A. Galella, K. McIntyre, 2015, Journal of medicinal chemistry.

Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-7918

A. Doweyko, D. Shuster, J. Barrish, 2011, Journal of medicinal chemistry.

Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators.

A. Doweyko, J. Barrish, T. Huynh, 2009, Bioorganic & medicinal chemistry letters.

Identification of chemokine receptor CCR4 antagonist.

J. Wityak, M. Poss, Wayne Vaccaro, 2005, Bioorganic & medicinal chemistry letters.

Macrophage regulation of B cell proliferation.

N. Goldman, J. Somerville, J. Riggs, 2017, Cellular immunology.

Erythropoietin increases macrophage-mediated T cell suppression.

M. Wood, N. Goldman, J. Somerville, 2016, Cellular immunology.

Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.

A. Doweyko, J. Barrish, S. Nadler, 2013, Bioorganic & medicinal chemistry letters.

Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.

J. Barrish, Hai-yun Xiao, S. Nadler, 2010, Journal of medicinal chemistry.

Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.

Michael G. Yang, A. Doweyko, D. Shuster, 2014, Bioorganic & medicinal chemistry letters.

Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists.

A. Doweyko, D. Shuster, J. Barrish, 2010, Journal of medicinal chemistry.

A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide.

R. Darveau, L. Cassiano, B. Bainbridge, 1996, The Journal of clinical investigation.

A Model of Nutrient Exchange in the Rhizobium-Legume Symbiosis

M. Kahn, J. Somerville, J. Kraus, 1985 .

Cloning of the glutamine synthetase I gene from Rhizobium meliloti

M. Kahn, J. Somerville, 1983, Journal of bacteriology.

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids

M. Weinblatt, N. Shadick, Somnath Bandyopadhyay, 2018, Arthritis & rheumatology.

Isolation, characterization, and complementation of Rhizobium meliloti 104A14 mutants that lack glutamine synthetase II activity

R. Shatters, M. Kahn, J. Somerville, 1989, Journal of bacteriology.

High macrophage PD-L1 expression not responsible for T cell suppression.

N. Goldman, A. Bucknum, J. Somerville, 2017, Cellular immunology.

Structure of the Bradyrhizobium japonicum gene hemA encoding 5-aminolevulinic acid synthase.

C. R. McClung, M. Guerinot, J. Somerville, 1987, Gene.

A High-Content Glucocorticoid Receptor Translocation Assay for Compound Mechanism-of-Action Evaluation

Mary Ellen Cvijic, Michele Agler, M. Cvijic, 2007, Journal of biomolecular screening.

Antagonists of CCR4 as immunomodulatory agents.

A. Purandare, J. Somerville, 2006, Current topics in medicinal chemistry.

Optimization of CCR4 antagonists: side-chain exploration.

K. McIntyre, M. Poss, Wayne Vaccaro, 2006, Bioorganic & medicinal chemistry letters.

Optimization of CCR4 Antagonists: Side‐Chain Exploration.

K. McIntyre, M. Poss, Wayne Vaccaro, 2006 .

Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core.

J. Barrish, Hai-yun Xiao, S. Nadler, 2013, Bioorganic & medicinal chemistry letters.

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

Michael A. Galella, D. Shen, J. Barrish, 2018, Bioorganic & medicinal chemistry letters.

Escherichia coli msbB Gene as a Virulence Factor and a Therapeutic Target

R. Darveau, L. Cassiano, J. Somerville, 1999, Infection and Immunity.

Expression of antibody fragments in Escherichia coli

H. P. Fell, R. Darveau, J. Somerville, 1992 .

Escherichia coli and Porphyromonas gingivalis lipopolysaccharide interactions with CD14: implications for myeloid and nonmyeloid cell activation.

J. Bajorath, R. Darveau, M. D. Cunningham, 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Bacterial aspects associated with the expression of a single-chain antibody fragment in Escherichia coli

H. P. Fell, R. Darveau, J. Somerville, 1994, Applied Microbiology and Biotechnology.