K. Tivel

发表

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

P. D. Cook, M. Manoharan, T. V. van Berkel, 1997, Nucleic acids research.

Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation.

M. Manoharan, T. V. van Berkel, T. V. Berkel, 2000, Nucleic acids research.

Pharmacokinetic properties of several novel oligonucleotide analogs in mice.

R. Griffey, M. Manoharan, S. Crooke, 1996, The Journal of pharmacology and experimental therapeutics.

Inhibition of expression of the multidrug resistance-associated P-glycoprotein of by phosphorothioate and 5' cholesterol-conjugated phosphorothioate antisense oligonucleotides.

M. Manoharan, N. Dean, R. Juliano, 1996, Molecular pharmacology.

Lipidic nucleic acids

P. D. Cook, M. Manoharan, K. Tivel, 1995 .

Modification of a Phosphorothioate Oligonucleotide with Cholesterol Induces Association of the Oligonucleotide to Serum Lipoproteins and Affects Its Biological Fate

P. D. Cook, M. Manoharan, T. J. Berkel, 1997 .

Base-Sequence Dependence of Emission Lifetimes for D141018-30-6NA Oligomers and Duplexes Covalently Labeled with Pyrene: Relative Electron-Transfer Quenching Efficiencies of A, G, C, and T Nucleosides toward Pyrene

M. Manoharan, T. Netzel, Kambiz Nafisi, 1995 .

2′- and 3′- Biotin Conjugated Nucleoside Building Blocks: Synthesis of Biotinylated Oligonucleotides

P. D. Cook, M. Manoharan, K. Stecker, 1997 .

2′-O- and 3′-O- pyrimidine aminotether-containing oligonucleotides: Synthesis and conjugation chemistry

P. D. Cook, M. Manoharan, K. Tivel, 1995 .

2′- and 3′- Cholesterol-Conjugated Adenosine and Cytosine Nucleoside Building Blocks: Synthesis of Lipidic Nucleic Acids

P. D. Cook, M. Manoharan, B. Ross, 1997 .

A 2'-O-thiol tether in the ribose moiety of nucleic acids for conjugation chemistry.

P. D. Cook, M. Manoharan, B. Ross, 1994, Gene.

Introduction of a lipophilic thioether tether in the minor groove of nucleic acids for antisense applications

P. D. Cook, M. Manoharan, K. Tivel, 1993 .

Introduction of a Lipophilic Thioether Tether in the Minor Groove of Nucleic Acids for Antisense Applications.

P. D. Cook, M. Manoharan, K. Tivel, 2010 .

Synthesis of 14 C-radiolabeled oligonucleotides with a novel phosphoramidite reagent.

M. Manoharan, A. Guzaev, K. Tivel, 1998, Bioorganic & medicinal chemistry letters.

SFC/MS in drug discovery at Pfizer, La Jolla

W. Farrell, T. Quenzer, Ben Bolanos, 2004 .

Oligonucleotide Conjugates: Alteration of the Pharmacokinetic Properties of Antisense Agents

P. D. Cook, M. Manoharan, V. Mohan, 1995 .

High-throughput preparative process utilizing three complementary chromatographic purification technologies.

O. Grøn, W. Farrell, M. Greig, 2004, Journal of chromatography. A.