K. Kohlhaas

发表

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

Nimrod D. Rubinstein, D. Donnelly-roberts, A. Swensen, 2018, bioRxiv.

eIF2B activator prevents neurological defects caused by a chronic Integrated Stress Response

Nimrod D. Rubinstein, D. Donnelly-roberts, A. Swensen, 2018 .

An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo

C. Briggs, E. Nielsen, M. Gopalakrishnan, 2007, Journal of Pharmacology and Experimental Therapeutics.

In Vivo Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease

K. Browman, J. Buccafusco, M. Decker, 2010, Journal of Pharmacology and Experimental Therapeutics.

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.

A. Gomtsyan, R. Snyder, Chih-Hung Lee, 2005, Bioorganic & medicinal chemistry.

Impact of neonatal NOS-1 inhibitor exposure on neurobehavioural measures and prefrontal-temporolimbic integration in the rat nucleus accumbens.

A. West, M. Wolf, K. Hoque, 2014, The international journal of neuropsychopharmacology.

Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.

Chih-Hung Lee, S. Bhagwat, E. Bayburt, 2005, Bioorganic & medicinal chemistry letters.

Preclinical abuse liability assessment of ABT-126, an agonist at the α7 nicotinic acetylcholine receptor (nAChR)

E. Mohler, J. J. Lynch, W. Bracken, 2017, Pharmacology Biochemistry and Behavior.

Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists.

E. Mohler, L. Rueter, R. Radek, 2010, Current pharmaceutical design.

Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

E. Kowaluk, J. Kerwin, M. Cowart, 1996 .

4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.

A. Gomtsyan, S. Muchmore, Chih-Hung Lee, 2007, Bioorganic & medicinal chemistry.

Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002, Pain.

Pyridopyrimidine analogues as novel adenosine kinase inhibitors.

A. Gomtsyan, S. Muchmore, M. Jarvis, 2001, Bioorganic & medicinal chemistry letters.

Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain

C. Surowy, L. Rueter, P. Curzon, 2003, Pain.

Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain

G. Dubé, C. Briggs, C. Surowy, 2005, Neuroscience Letters.

Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.

M. Jarvis, C. Lee, K. Kohlhaas, 2001, Bioorganic & medicinal chemistry letters.

5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.

Chih-Hung Lee, S. Bhagwat, E. Bayburt, 2003, Journal of medicinal chemistry.

Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.

Chih-Hung Lee, Changcheng Zhu, M. Jarvis, 2003, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.

A. Gomtsyan, Chih-Hung Lee, S. Bhagwat, 2002, Journal of medicinal chemistry.

Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.

S. Bhagwat, E. Bayburt, M. Jarvis, 2001, Bioorganic & medicinal chemistry letters.

PII: S0304-3959(01)00435-3

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002 .

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.

M. Williams, M. Jarvis, E. Kowaluk, 2000, The Journal of pharmacology and experimental therapeutics.

Characterization of the Effects of Adenosine Kinase Inhibitors on Acute Thermal Nociception in Mice

K. Gunther, A. Bannon, M. Jarvis, 1999, Pharmacology Biochemistry and Behavior.

Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.

R. Henry, T. Dyhring, C. Surowy, 2006, Journal of medicinal chemistry.

Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis

M. Gopalakrishnan, L. Rueter, R. Bitner, 2012, Psychopharmacology.

Chronic low dose risperidone and clozapine alleviate positive but not negative symptoms in the rat neonatal ventral hippocampal lesion model of schizophrenia

M. E. Ballard, L. Rueter, P. Curzon, 2004, Psychopharmacology.

Nitric oxide synthase in ferret brain: localization and characterization

F. Murad, J. Mitchell, H. Schmidt, 1992, British journal of pharmacology.

Effect of Dopamine D3 Antagonists on PPI in DBA/2J Mice or PPI Deficit Induced by Neonatal Ventral Hippocampal Lesions in Rats

Min Zhang, K. Browman, A. Jongen-Rêlo, 2006, Neuropsychopharmacology.

Nicotinic modulation of auditory evoked potential electroencephalography in a rodent neurodevelopmental model of schizophrenia.

L. Rueter, K. Kohlhaas, Holly M. Robb, 2015, Biochemical pharmacology.

Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.

E. Kowaluk, J. Kerwin, M. Cowart, 1998, Journal of Medicinal Chemistry.

Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-beta.

F. Murad, H. Schmidt, U. Förstermann, 1992, European journal of pharmacology.

Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors

F. Murad, J. Vane, J. Mitchell, 1993, British journal of pharmacology.

Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages.

F. Murad, H. Schmidt, J. Pollock, 1992, Molecular pharmacology.

Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties

J. Waring, S. Otte, K. Browman, 2008, CNS neuroscience & therapeutics.

Impact of neonatal NOS-1 inhibitor exposure on neurobehavioural measures and prefrontal-temporolimbic integration in the rat nucleus accumbens.

A. West, M. Wolf, K. Hoque, 2014, The international journal of neuropsychopharmacology.

Augmentation of cognitive function by NS9283, a stoichiometry‐dependent positive allosteric modulator of α2‐ and α4‐containing nicotinic acetylcholine receptors

E. Nielsen, T. Dyhring, D. Peters, 2012, British journal of pharmacology.

Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis

M. Gopalakrishnan, L. Rueter, R. Bitner, 2011, Psychopharmacology.

Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

J. Waring, Jinhe Li, Chih-Hung Lee, 2013, Alzheimer's & Dementia.