N. Benoiton

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N‐METHYLAMINO ACIDS IN PEPTIDE SYNTHESIS PART 4, RACEMIZATION AND YIELDS IN PEPTIDE‐BOND FORMATION

J. Mcdermott, N. Benoiton, 1973 .

Peptide Synthesis: Coupling Methods

N. Benoiton, 2008 .

2-ALKOXY-5 (4H) -OXAZOLONES AND THE ENANTIOMERIZATION OF N-ALKOXYCARBONYLAMINO ACIDS

N. Benoiton, 1996 .

Studies on sensitivity to racemization of activated residues in couplings of N-benzyloxycarbonyldipeptides.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

Metabolism of o-hydroxy-L- and o-hydroxy-D-phenylalanine-2-14C in the rat.

C. Petitclerc, N. Benoiton, A. D'lorio, 1969, Canadian journal of biochemistry.

Formation of meta-tyrosine form L-phenylalanine by beef adrenal medulla. A new biosynthetic route to catecholamines.

N. Benoiton, A. D'iorio, J. Tong, 1971, Biochemical and biophysical research communications.

The carboxypeptidase B-catalyzed hydrolysis of poly-ϵ-N-methyl-L-lysine and poly-ϵ-N, ϵ-N-dimethyl-L-lysine☆

J. H. Seely, N. Benoiton, 1969 .

A quick separation of the ϵ-N-methyl-lysines using the amino acid analyzer

J. H. Seely, N. Benoiton, R. Edattel, 1969 .

Synthesis and resolution of o‐hydroxy‐DL‐phenylalanine‐2‐14C

C. Petitclerc, N. Benoiton, A. D'iorio, 1969 .

A new method of quaternizing amines and its use in amino acid and peptide chemistry

N. Benoiton, Francis M. F. Chen, 1976 .

Determination of several ammonia or amino acid samples on one chromatogram with an amino acid analyzer.

J. H. Seely, N. Benoiton, R. Edattel, 1969, Journal of chromatography.

Studies on racemization during couplings using a series of model tripeptides involving activated residues with unfunctionalized side chains.

N. Benoiton, K. Kuroda, 2009, International journal of peptide and protein research.

A Simple Preparation of 5-Oxo-4,5-dihydro-1,3-oxazoles (Oxazolones)

N. Benoiton, K. Kuroda, Francis M. F. Chen, 1979 .

Racemisation of activated, urethane-protected amino-acids by p-dimethyl-aminopyridine. Significance in solid-phase peptide synthesis

R. Sheppard, B. Williams, E. Atherton, 1981 .

Simple preparations of N-(tert-butyloxycarbonyl)-O-methyl-L-serine and N-(tert-butyloxycarbonyl)-O-methyl-L-threonine by direct methylation

N. Benoiton, Francis M. F. Chen, 1979 .

Positive cooperativity in the porcine carboxypeptidase B-catalyzed hydrolysis of neutral peptide substrates.

G. J. Moore, N. Benoiton, 1972, Biochemical and biophysical research communications.

N-Methylamino acids in peptide synthesis. V. The synthesis of N-tert-butyloxycarbonyl, N-methylamino acids by N-methylation

N. Benoiton, S. Cheung, 1977 .

N-Methylamino Acids in Peptide Synthesis. II. A New Synthesis of N-Benzyloxycarbonyl, N-Methylamino Acids

J. Mcdermott, N. Benoiton, 1973 .

Mixed carboxylic-carbonic acid anhydrides of acylamino acids and peptides as a convenient source of 2,4-dialkyl-5(4H)-oxazolones

M. Ślebioda, N. Benoiton, Francis M. F. Chen, 2009 .

A General Method for Formylating Sensitive Amino Acid Esters

N. Benoiton, Francis M. F. Chen, 1979 .

A General Method for Formylating Sensitive Amino Acid Esters

N. Benoiton, Francis M. F. Chen, 1979 .

Studies on racemization associated with the use of benzotriazol-1-yl-tris (dimethylamino)phosphonium hexafluorophosphate (BOP).

R. Steinauer, N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

STRUCTURAL REQUIREMENTS IN CHIRAL DIPHOSPHINE‐RHODIUM COMPLEXES. XII. ASYMMETRIC HOMOGENEOUS HYDROGENATION OF Z‐α‐N‐METHYLACETAMIDOCINNAMIC ACID AND METHYL ESTER CATALYZED BY RHODIUM(I) COMPLEXES OF DIOP AND ITS CARBOCYCLIC ANALOGS

R. Glaser, N. Benoiton, S. Geresh, 1978 .

A series of lysyldipeptide derivatives for racemization studies in peptide synthesis.

N. Benoiton, F. Chen, K. Kuroda, 2009, International journal of peptide and protein research.

N-9-fluorenylmethoxycarbonylpyroglutamate. Preparation of the acid, chloride and succinimidyl ester.

N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

Preparation of N-9-fluorenylmethoxycarbonylamino acid chlorides from mixed anhydrides by the action of hydrogen chloride.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

High-performance liquid chromatography of 2,4-disubstituted-5(4H)-oxazolones, anhydrides and other activated forms of N-acyl- and N-alkoxycarbonylamino acids.

N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

Mixed anhydrides in peptide synthesis. Reduction of urethane formation and racemization using N-methylpiperidine as the tertiary amine base

N. Benoiton, Francis M. F. Chen, Rene Stainauer, 1983 .

N-methylamino acids in peptide synthesis: VIII. A simple procedure for monitoring the N-methylation reaction using high-performance liquid chromatography

R. Steinauer, N. Benoiton, Francis M. F. Chen, 2009 .

N,N-dialkoxycarbonylamino acids from the sodium hydride-mediated reaction of alkyl chloroformates with mixed anhydrides of N-alkoxycarbonylamino acids.

N. Benoiton, F. Chen, D. Akyurekli, 2009, International journal of peptide and protein research.

The dolastatins 25. Conformational isomerism of N-benzyloxycarbonl-N-methylisoleucinol and related substances

Michael D. Williams, G. Pettit, J. Srirangam, 1995 .

Determination of epimeric peptides for assessing enantiomeric purity of starting materials and studying racemization in peptide synthesis using high-performance liquid chromatography☆

R. Steinauer, N. Benoiton, Francis M. F. Chen, 1985 .

Chemistry of Peptide Synthesis

N. Benoiton, 2005 .

Identification and suppression of decomposition during carbodiimide-mediated reactions of Boc-amino acids with phenols, hydroxylamines and amino acid ester hydrochlorides.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

General procedure for preparing a reference mixture and determining the amount of dipeptide contaminant in N-alkoxycarbonylamino acids by high-performance liquid chromatography

R. Steinauer, N. Benoiton, Francis M. F. Chen, 2009 .

N-alkoxycarbonyl-glutamic and aspartic acids. Studies on the activation and cyclodehydration and side-reaction encountered in analysis of glutamic acid using Fmoc-chloride.

N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

Racemization of acylamino acids and the carboxy‐terminal residue of peptides

N. Benoiton, Francis M. F. Chen, 2009 .

1H n.m.r. long-range coupling in 2,4-disubstituted-5(4H)-oxazolones and 4-alkyl-5(2H)-oxazolones generated therefrom by the action of triethylamine.

N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

Diisopropylethylamine eliminates dipeptide formation during the acylation of amino acids using benzoyl chloride and some alkyl chloroformates

N. Benoiton, Francis M. F. Chen, 1987 .

Mixed anhydrides in peptide synthesis. A study of urethane formation with a contribution on minimization of racemization

R. Steinauer, N. Benoiton, Francis M. F. Chen, 1987 .

The preparation and reactions of mixed anhydrides of N-alkoxycarbonylamino acids

N. Benoiton, Francis M. F. Chen, 1987 .

The dependence of asymmetric induction on solvent polarity and temperature in peptide synthesis

N. Benoiton, K. Kuroda, Francis M. F. Chen, 1982 .

Not the alkoxycarbonylamino-acid O-acylisourea

N. Benoiton, Francis M. F. Chen, 1981 .

The Effect of N-Substitution on the Rates of Saponification of Some Amino Acid Esters

N. Benoiton, J. E. Purdie, 1971 .

Preparation of activated esters of N-alkoxycarbonylamino and other acids by a modification of the mixed anhydride procedure.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

A new method of quaternizing amines and its use in amino acid and peptide chemistry

N. Benoiton, Francis M. F. Chen, 1976 .

Transamination of ring-substituted L-phenylalanines by an extract from rat liver mitochondria.

N. Benoiton, A. D'iorio, J. Tong, 1973, Canadian journal of biochemistry.

High-performance liquid chromatography of epimeric N-protected peptide acids and esters for assessing racemization

R. Steinauer, N. Benoiton, B. Liberek, 2009 .

Piperazinedione formation from esters of dipeptides containing glycine, alanine, and sarcosine: the kinetics in aqueous solution

N. Benoiton, J. E. Purdie, 1973 .

Synthesis of N-Methylamino Acid Derivatives from Amino Acid Derivatives using Sodium Hydride/Methyl Iodide

J. Coggins, N. Benoiton, 1971 .

The methylation of some phenols and alcohols with sodium hydride / methyl iodide in tetrahydrofuran at room temperature☆

N. Benoiton, B. Stoochnoff, 1973 .

Preparation of 2-alkoxy-4-alkyl-5(4H)-oxazolones from mixed anhydrides of N-alkoxycarbonylamino acids.

N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

2-Alkoxy-5(4H)-oxazolones from N-alkoxycarbonylamino acids and their implication in carbodiimide-mediated reactions in peptide synthesis

N. Benoiton, Francis M. F. Chen, 1981 .

2,4-Dimethyl-5(4H)-oxazolone as reagent for activation and coupling of N-substituted aspartic acid.

N. Benoiton, F. Chen, 2009, International journal of peptide and protein research.

Studies on the disproportionation of mixed anhydrides of N-alkoxycarbonylamino acids.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

General procedures for preparing 2-alkoxy-5(4H)-oxazolones from mixed anhydrides and for determining activated forms of amino acids by HPLC

N. Benoiton, Francis M. F. Chen, 1991 .

Further studies on the synthesis of symmetrical anhydrides and 2,4-disubstituted-5(4H)-oxazolones from N-alkoxycarbonylamino acids using soluble carbodiimide

N. Benoiton, Francis M. F. Chen, A. Paquet, 1984 .

Reaction of N-t-butoxycarbonylamino acid anhydrides with tertiary amines and carbodi-imides. New precursors for 2-t-butoxyoxazol-5(4H)-one and N-acylureas

N. Benoiton, Francis M. F. Chen, 1981 .

Racemization during aminolysis of mixed and symmetrical anhydrides of N-alkoxycarbonylamino acids by amino acid anions in aqueous dimethylformamide

N. Benoiton, Francis M. F. Chen, Young C. Lee, 2009 .

Racemization during aminolysis of activated esters of N-alkoxycarbonylamino acids by amino acid anions in partially aqueous solvents and a tactic to minimize it.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

Identification of the Side-Reaction of Boc-Decomposition During the Coupling of Boc-Amino Acids with Amino Acid Ester Salts,

N. Benoiton, Francis M. F. Chen, 1992 .

Reaction mechanisms in peptide synthesis. Part 2. Tautomerism of the peptide bond

Jerzy Ciarkowski, Francis M. F. Chen, N. Leo Benoiton, 1991, J. Comput. Aided Mol. Des..

Activation and Racemization in Peptide Bond Formation

N. Benoiton, F. Chen, 1990 .

Examination of chiral stability during the preparation of hydrazides and coupling by the azide procedure using a series of model peptides.

N. Benoiton, F. Chen, K. Kuroda, 2009, International journal of peptide and protein research.

Determination of N-methylamino acids and their optical purity with an amino acid analyzer.

J. Coggins, N. Benoiton, 1970, Journal of chromatography.

Studies on asymmetric induction associated with the coupling of N-acylamino acids and N-benzyloxycarbonyldipeptides.

N. Benoiton, F. Chen, Y. Lee, 2009, International journal of peptide and protein research.

4-Alkyl-5(4H)-oxazolones from mixed anhydrides of N-formylamino acids.

N. Benoiton, 2009, International journal of peptide and protein research.

Reaction mechanisms in peptide synthesis. Part 1. Semiquantitative characteristics of the reactivity of 2-methyl-5(4H)-oxazolone with water and ammonia in the gas phase and weakly polar media

Jerzy Ciarkowski, Francis M. F. Chen, N. Leo Benoiton, 1991, J. Comput. Aided Mol. Des..

Racemization in peptide synthesis. A laboratory experiment for senior undergraduates.

N. Benoiton, F. Chen, K. Kuroda, 2009, International journal of peptide and protein research.

Amino-acid conjugates of the hapten 2-phenyl-4-ethoxymethylene-5(4H)-oxazolone. Synthesis and confirmation of structure.

N. Benoiton, F. Chen, F. Hudecz, 2009, International journal of peptide and protein research.

Effect of N-methylation and chain length on kinetic constants of trypsin substrates. Epsilon-N-methyllysine and homolysine derivatives as substrates.

J. H. Seely, N. Benoiton, 1970, Canadian journal of biochemistry.

Letter to the editor: Hydrochloride salts of amino acid benzyl esters from p-toluenesulfonate salts

N. Benoiton, Francis M. F. Chen, 2009 .

A Simple Preparation of Symmetrical Anhydrides of N-Alkyloxycarbonylamino Acids

N. Benoiton, K. Kuroda, Francis M. F. Chen, 1978 .

The trypsin-catalysed hydrolysis of D-lysine and D-arginine ethyl esters.

J. H. Seely, N. Benoiton, J. E. Purdie, 1972, Biochimica et biophysica acta.

Solid-Phase Synthesis

N. Benoiton, 2005 .

N-Ethylamino acid synthesis and N-acylamino acid cleavage using Meerwein's reagent

N. Benoiton, Francis M. F. Chen, 1977 .

A modified synthesis of -N-carbobenzoxy-L-lysine and the preparation and analysis of mixtures of -N-methyllysines.

J. Coggins, G. J. Moore, N. Benoiton, 1971, Canadian Journal of Biochemistry.

Lysyl dipeptide and tripeptide model systems for racemization studies in amino acid and peptide chemistry.

N. Benoiton, F. Chen, K. Kuroda, 1979, Canadian journal of biochemistry.

N-Methylamino acids in peptide synthesis. VI. A method for determining the enantiomeric purity of N-methylamino acids and their derivatives by ion-exchange chromatography as their C-terminal lysyl dipeptides

N. Benoiton, S. Cheung, 1977 .

A synthesis of N6,N6,N6-trimethyl-L-lysine dioxalate in gram amounts.

N. Benoiton, F. Chen, 1986, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The formation of 3,4-dihydroxy-L-phenylalanine from L-meta-tyrosine by rat liver and beef adrenal medulla.

N. Benoiton, A. D'iorio, J. Tong, 1971, Biochemical and biophysical research communications.

A new biosynthetic pathway to catecholamines via m-tyrosine.

N. Benoiton, S. Sharma, J. Tong, 1974, Advances in neurology.

In vivo studies on the conversion of m-tyrosine to 3,4-dihydroxyphenylalanine in the rat.

N. Benoiton, A. D'iorio, R. G. Smyth, 1977, Canadian Journal of Biochemistry.