Graciela Mahler

发表

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

A. Vila, M. Rossi, Antonella R Palacios, 2020, Biomolecules.

Structure-Based Bioisosterism Design, Synthesis, Biological Evaluation and In Silico Studies of Benzamide Analogs as Potential Anthelmintics

G. Salinas, M. Paulino, Graciela Mahler, 2022, Molecules.

Synthesis of enantiomerically enriched α,α-disubstituted β,γ-epoxy esters using hydrolytic kinetic resolution catalyzed by salenCo(III)

E. Manta, Graciela Mahler, Ignacio Viera, 2010 .

Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi

P. Wipf, G. Salinas, C. Robello, 2012 .

2-Mercaptomethyl-thiazolidines use conserved aromatic–S interactions to achieve broad-range inhibition of metallo-β-lactamases

R. Bonomo, G. Drusano, C. Banchio, 2021, Chemical science.

Preparation and mechanistic studies of 2-substituted Bisthiazolidines by imine exchange.

N. Veiga, D. Davyt, C. Fontana, 2020, European journal of organic chemistry.

Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones

V. Moreno, D. Gambino, F. Caruso, 2013, Biological Trace Element Research.

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.

R. Bonomo, C. Schofield, J. Brem, 2015, ACS infectious diseases.

Thioester deprotection using a biomimetic NCL approach

Valentina Villamil, Graciela Mahler, C. Saiz, 2022, Frontiers in Chemistry.

A new procedure for thioester deprotection using thioglycolic acid in both homogeneous and heterogeneous phase.

Valentina Villamil, Graciela Mahler, C. Saiz, 2021, Tetrahedron.

USE OF BARIUM MANGANATE FOR THIAZOLINES AND OXAZOLINES OXIDATION

G. Serra, E. Manta, Graciela Mahler, 2008 .

Synthesis and biological evaluation of simplified mycothiazole analogues.

G. Serra, S. Dematteis, E. Manta, 2006, Bioorganic & medicinal chemistry letters.

Reversible thiazolidine exchange: a new reaction suitable for dynamic combinatorial chemistry.

P. Wipf, E. Manta, Graciela Mahler, 2009, Organic letters.

Synthesis and ring-chain-ring tautomerism of bisoxazolidines, thiazolidinyloxazolidines, and spirothiazolidines.

P. Wipf, Graciela Mahler, C. Saiz, 2011, Journal of Organic Chemistry.

Enantioselective synthesis of new oxazolidinylthiazolidines as enzyme inhibitors.

L. Suescun, A. Vila, Valentina Villamil, 2017, Tetrahedron, asymmetry.

Synthesis of bicyclic 1,4-thiazepines as novel anti-Trypanosoma brucei brucei agents.

Vojtech Jancik, Andrea Medeiros, G. Salinas, 2019, MedChemComm.

Imidazolium compounds are active against all stages of Trypanosoma cruzi.

P. Wipf, C. Robello, Mary Liang, 2014, International journal of antimicrobial agents.

2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode.

R. Bonomo, G. Drusano, C. Banchio, 2021, ACS infectious diseases.

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

R. Bonomo, J. Spencer, A. Vila, 2016, Proceedings of the National Academy of Sciences.

New preparation protocols for coumarin-thiosemicarbazone hybrids: solid state characterization, and in silico/NMR studies of the Z/E isomerization equilibria in solution

N. Alvarez, N. Veiga, S. Rostán, 2021, Journal of Molecular Structure.

Synthesis of 2‐Amino‐octa‐4,7‐Dien‐1‐ol (2): Key Intermediate for Mycothiazole Natural Product and Analogs

G. Serra, E. Manta, Graciela Mahler, 2005 .

Synthesis of 2-Amino-octa-4,7-dien-1-ol. Part 2. Key Intermediate for Mycothiazole Natural Product and Analogues.

G. Serra, E. Manta, Graciela Mahler, 2005 .

Synthesis of Methyl 2-(1′,1′-Dimethyl-2′-oxopropyl)thiazole-4-carboxylate and Related 2,4-Disubstituted Thiazoles. Key Intermediates in the Synthesis of Anthelmintic Agents Based on Marine Natural Product.

G. Serra, E. Manta, Graciela Mahler, 1999 .

Synthesis of Methyl 2-(1',1'-Dimethyl-2'-oxopropyl)thiazole-4-carboxylate and Related 2,4-Disubstituted Thiazoles. Key Intermediates in the Synthesis of Anthelmintic Agents Based on Marine Natural Product

G. Serra, E. Manta, Graciela Mahler, 1998 .

Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones

V. Moreno, D. Gambino, F. Caruso, 2013, Biological Trace Element Research.

A multiscale approach to predict the binding mode of metallo beta‐lactamase inhibitors

A. Mulholland, A. Pedretti, J. Spencer, 2021, Proteins.

Synthesis of an Albendazole Metabolite: Characterization and HPLC Determination.

L. Scarone, D. Davyt, G. Serra, 2008 .

Woollins’ reagent promotes selective reduction of α,β-unsaturated thiazo and selenazolidinones

Graciela Mahler, Chiara Pizzo, 2017 .

Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases.

R. Bonomo, C. Bethel, M. Harris, 2015, Biochemistry.