San-qi Zhang

发表

The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice.

Yan Li, Wen Lu, Lang-chong He, 2008, International journal of biological macromolecules.

Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents.

Yong-xiao Cao, Sen‐Lan Li, San-qi Zhang, 2014, Bioorganic & medicinal chemistry letters.

Study on the characteristics of pectin-ketoprofen for colon targeting in rats.

San-qi Zhang, Miao-miao Xi, X. Wang, 2005, International journal of pharmaceutics.

The dual luciferase reporter system and RT‐qPCR strategies for screening of MicroRNA‐21 small‐molecule inhibitors

Yuanxu Guo, Congshan Jiang, San-qi Zhang, 2019, Biotechnology and applied biochemistry.

F10, a new camptothecin derivative, was identified as a new orally-bioavailable, potent antitumor agent.

Lei Cao, Shu Fan, Yong-xiao Cao, 2020, European journal of medicinal chemistry.

Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents.

Sai Zhang, Yong-xiao Cao, San-qi Zhang, 2016, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors.

Yan Li, San-qi Zhang, She-min Lu, 2012, Bioorganic & medicinal chemistry.

Overcoming C797S mutation: The challenges and prospects of the fourth-generation EGFR-TKIs.

San-qi Zhang, Minhang Xin, Hong-Yi Zhao, 2022, Bioorganic chemistry.

Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

Yan Li, Yong-xiao Cao, San-qi Zhang, 2011, Medicinal Chemistry Research.

W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors

W. Han, Shu Fan, Man-li Wu, 2019, Investigational New Drugs.

Quantitative analysis and pharmacokinetic study of a novel diarylurea EGFR inhibitor (ZCJ14) in rat plasma using a validated LC-MS/MS method

Yong-xiao Cao, San-qi Zhang, Xiaoliang Cheng, 2020, Acta pharmaceutica.

Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazinylcarbonyl moiety

San-qi Zhang, W. Xuan, Wenjiao Ding, 2013, Medicinal Chemistry Research.

Metal-free photo-induced sulfidation of aryl iodide and other chalcogenation

Jianping Hu, X. Ye, Mingliang Wang, 2022, Frontiers in Chemistry.

Discovery of novel taspine derivatives as antiangiogenic agents.

Yanmin Zhang, Langchong He, Sicen Wang, 2010, Bioorganic & medicinal chemistry letters.

Menin-MLL protein-protein interaction inhibitors: a patent review (2014–2021)

Fang Wang, Haolan Lei, San-qi Zhang, 2022, Expert opinion on therapeutic patents.

Synthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature.

Pengfei Li, San-qi Zhang, Zhengkai Chen, 2018, The Journal of organic chemistry.

Metal-Free C-2-H Alkylation of Quinazolin-4-ones with Alkanes via Cross-Dehydrogenative Coupling.

N. Neamati, Yi Jin, San-qi Zhang, 2019, Organic letters.

Novel galactosylated SLN for hepatocyte-selective targeting of floxuridinyl diacetate

Yanmin Zhang, Yongwei Hao, San-qi Zhang, 2008 .

Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx

Xinlin Chen, Yong-xiao Cao, San-qi Zhang, 2013, Pharmacological reports : PR.

Small molecule selenium-containing compounds: Recent development and therapeutic applications.

Jiajia Sun, Jiye Zhang, San-qi Zhang, 2021, European journal of medicinal chemistry.

Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.

Yongyi Mao, Haolan Lei, San-qi Zhang, 2022, Journal of medicinal chemistry.

Vasodilation and hypotension of a novel 3-benzylquinazolin- 4(3H)-one derivative via the inhibition of calcium flux.

Lei Cao, Yong-xiao Cao, San-qi Zhang, 2016, European journal of pharmacology.

Total synthesis of the phenylpropanoid glycoside, grayanoside A

Zhong-Jun Li, San-qi Zhang, M. Cai, 1997 .

Triazene as the Directing Group Achieving Highly Ortho-Selective Diborylation and Sequential Functionalization.

Pengfei Li, San-qi Zhang, Xue-Yan Yang, 2022, Organic letters.

Anti-HBV effect of targeted lamivudy palmitate solid lipid nano-particles

Yi-qun Gu, Ping-zhong Wang, X. Bai, 2003 .

Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo.

Jing Xu, Huan-qiu Li, San-qi Zhang, 2013, European journal of medicinal chemistry.

Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors.

A. Zheng, Shu Fan, Haolan Lei, 2019, European journal of medicinal chemistry.

Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors.

Yifan Feng, Haopeng Sun, San-qi Zhang, 2019, Bioorganic & medicinal chemistry.

Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp2 C-H bond amination mediated by cupric acetate.

San-qi Zhang, Shuai Mao, Minhang Xin, 2017, Organic & biomolecular chemistry.

K2S2O8-promoted C–Se bond formation to construct α-phenylseleno carbonyl compounds and α,β-unsaturated carbonyl compounds

Jianjun Li, San-qi Zhang, Shuai Mao, 2020, RSC advances.

Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazinylcarbonyl moiety

San-qi Zhang, Wenjiao Ding, Hong-xiang Hui, 2013, Medicinal Chemistry Research.

Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety.

San-qi Zhang, Shuai Mao, Hao Zhang, 2015, Bioorganic & medicinal chemistry.

Combination of 2-methoxy-3-phenylsulfonylaminobenzamide and 2-aminobenzothiazole to discover novel anticancer agents.

Juan Wang, Q. Mei, Huan-qiu Li, 2014, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H,4H)-diones in vitro and in vivo

Yan Li, San-qi Zhang, Huan Li, 2013, Medicinal Chemistry Research.

Novel compound ZCJ14, a gefitinib analog, exhibited prominent anti-cancer effect among several cancer cell lines.

Lei Cao, Yong-xiao Cao, San-qi Zhang, 2022, Life sciences.

Cu-mediated selective bromination of aniline derivatives and preliminary mechanism study

Haolan Lei, San-qi Zhang, Minhang Xin, 2019, Synthetic Communications.

Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro.

J. Xu, San-qi Zhang, Min-Hang Xin, 2015, Bioorganic & medicinal chemistry letters.

Three new asterosaponins from the starfish Culcita novaeguineae and their bioactivity.

P. Sun, Ling Li, Y. Yi, 2005, Planta medica.

Synthesis of a phenylpropanoid glycoside, Osmanthuside B6

Zhong-Jun Li, San-qi Zhang, M. Cai, 1998 .

Synthesis based on affinity separation (SAS): Separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction

Minoru Izumi, K. Fukase, S. Kusumoto, 2001 .

New Efficient Route for Synthesis of Lipid A by using Affinity Separation

K. Fukase, S. Kusumoto, M. Oikawa, 2001 .

New methodology for high throughput solution-phase synthesis: affinity purification by using crown ether and ammonium ion interaction

K. Fukase, S. Kusumoto, San-qi Zhang, 1999 .

Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Yifan Feng, San-qi Zhang, Shuai Mao, 2018, Bioorganic & medicinal chemistry.

Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors

San-qi Zhang, Minhang Xin, Hao Zhang, 2020, Journal of Chemical Research.

Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors.

Yifan Feng, Shu Fan, San-qi Zhang, 2019, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors.

San-qi Zhang, Shuai Mao, Yuan-Yuan Hei, 2016, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors

Shemin Lu, Yuanxu Guo, Congshan Jiang, 2022, Journal of pharmaceutical analysis.

Novel PI3K/Akt/mTOR signaling inhibitor, W922, prevents colorectal cancer growth via the regulation of autophagy

Lei Cao, Yong-xiao Cao, San-qi Zhang, 2020, International journal of oncology.

Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).

San-qi Zhang, Shuai Mao, Minhang Xin, 2020, European journal of medicinal chemistry.

Progress of small molecules for targeted protein degradation: PROTACs and other technologies

San-qi Zhang, Minhang Xin, Hong-Yi Zhao, 2023, Drug development research.

Discovery of potent small molecule PROTACs targeting mutant EGFR.

Haolan Lei, San-qi Zhang, Minhang Xin, 2020, European journal of medicinal chemistry.

Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.

Yong-xiao Cao, San-qi Zhang, Yuan-Yuan Hei, 2018, European journal of medicinal chemistry.

Discovery of 2-aryl-8-hydroxy (or methoxy)-isoquinolin-1(2H)-ones as novel EGFR inhibitor by scaffold hopping.

Jing Xu, San-qi Zhang, She-min Lu, 2013, Bioorganic & medicinal chemistry.

Research Advances on Selective Phosphatidylinositol 3 Kinase δ (PI3Kδ) Inhibitors.

Jiajia Sun, Yifan Feng, San-qi Zhang, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity.

Juan Wang, Q. Mei, Huan-qiu Li, 2015, Bioorganic & medicinal chemistry.

Modification of N-(6-(2-methoxy-3-(4-fluorophenylsulfonamido)pyridin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide as PI3Ks inhibitor by replacement of the acetamide group with alkylurea.

Lei Cao, Yong-xiao Cao, San-qi Zhang, 2015, Bioorganic & medicinal chemistry.

Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo.

J. Xu, Yan Li, San-qi Zhang, 2015, European journal of medicinal chemistry.

Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides as novel PI3K inhibitors and anticancer agents by bioisostere.

Juan Wang, Q. Mei, Yan Li, 2014, European journal of medicinal chemistry.

Asterosaponins from the starfish Culcita novaeguineae and their bioactivities.

P. Sun, Ling Li, Y. Yi, 2006, Fitoterapia.

Bioactive asterosaponins from the starfish Culcita novaeguineae.

P. Sun, Ling Li, Y. Yi, 2005, Journal of natural products.

Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.

Yong-xiao Cao, Haolan Lei, San-qi Zhang, 2018, Bioorganic & medicinal chemistry.

Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs.

H. Xiong, San-qi Zhang, Xue-Yan Yang, 2022, Bioorganic chemistry.

Recent Progress of Small Molecule Menin-MLL Interaction Inhibitors as Therapeutic Agents for Acute Leukemia.

Shu Fan, Haolan Lei, San-qi Zhang, 2021, Journal of medicinal chemistry.

Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.

Yan Li, Yong-xiao Cao, San-qi Zhang, 2018, Bioorganic & medicinal chemistry.

Discovery of 4-benzoylamino-N-(prop-2-yn-1-yl)benzamides as novel microRNA-21 inhibitors.

L. Meng, Shemin Lu, J. Xu, 2015, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H,4H)-diones in vitro and in vivo

Juan Wang, Q. Mei, Yan Li, 2014, Medicinal Chemistry Research.

Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

Yifan Feng, San-qi Zhang, Shuai Mao, 2018, Journal of enzyme inhibition and medicinal chemistry.

Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors.

San-qi Zhang, Yuan-Yuan Hei, Minhang Xin, 2017, Bioorganic & medicinal chemistry letters.

A novel small-molecule PI3K/Akt signaling inhibitor, W934, exhibits potent antitumor efficacy in A549 non-small-cell lung cancer.

Lei Cao, Yong-xiao Cao, San-qi Zhang, 2019, Anti-cancer drugs.

Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor.

San-qi Zhang, Yuan-Yuan Hei, Minhang Xin, 2018, Future medicinal chemistry.

Synthesis and Biological Evaluation of 10‐Substituted Camptothecin Derivatives with Improved Water Solubility and Activity

Haolan Lei, San-qi Zhang, Shuai Mao, 2020, ChemMedChem.

Discovery of 6-benzamide Containing 4-phenylquinazoline Derivatives as Novel PI3Kδ Inhibitors

San-qi Zhang, Shuai Mao, Yuan-Yuan Hei, 2016 .

Discovery of Novel, Potent, and Selective Small-Molecule Menin-Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups.

Jiajia Sun, Haolan Lei, San-qi Zhang, 2022, Journal of medicinal chemistry.

Irreversible epidermal growth factor receptor inhibitor Z25h exhibits pronounced inhibition on non-small cell lung adenocarcinoma cell line Hcc827.

Wei Li, Yong-xiao Cao, Shuai Tan, 2020, Anti-cancer drugs.

Efficient Synthesis of Thalifoline and Its Analogs

Sicen Wang, San-qi Zhang, Qiang Li, 2009 .

Discovery of potent and selective PI3Kδ inhibitors bearing amino acid fragments.

Yifan Feng, Haolan Lei, San-qi Zhang, 2023, Bioorganic chemistry.

Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription.

Shemin Lu, Yuanxu Guo, Congshan Jiang, 2022, Bioorganic & medicinal chemistry.

Vasodilation effect of 2-benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin-1-one

Yong-xiao Cao, Han Yu, San-qi Zhang, 2012, Archives of pharmacal research.

Vasodilation effect of 2-benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin-1-one

Yong-xiao Cao, San-qi Zhang, Zhiyang Xiong, 2012, Archives of pharmacal research.

Discovery of novel 2-benzylisoquinolin-1(2H)-ones as potent vasodilative agents.

Yong-xiao Cao, Sen‐Lan Li, San-qi Zhang, 2015, Bioorganic & medicinal chemistry letters.

Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors.

San-qi Zhang, Hong-Yi Zhao, Xiao-Xiao Xi, 2023, Bioorganic & medicinal chemistry letters.

Solubility of three types of benzamide derivatives in toluene, ethyl acetate, acetone, chloroform, methanol, and water at temperatures ranging from 288.15 to 328.15 K at atmospheric pressure

Guanjun Nan, Guangde Yang, Xiao-li Bian, 2015 .

Copper-Mediated monochlorination of anilines and nitrogen-containing heterocycles

San-qi Zhang, Shuai Mao, Xue-Yan Yang, 2018, Synthetic Communications.

Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

Yan Li, Yong-xiao Cao, San-qi Zhang, 2011, Medicinal Chemistry Research.

Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of nitrendipine analogues

Yong-xiao Cao, San-qi Zhang, Yiming Zhao, 2010, Medicinal Chemistry Research.

Design, synthesis and bioactivity evaluation of selenium-containing PI3Kδ inhibitors

Yang Wang, San-qi Zhang, Minhang Xin, 2023, Bioorganic Chemistry.