L. Foukas

发表

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

B. Vanhaesebroeck, K. Ali, W. Pearce, 2013, EMBO molecular medicine.

Direct Interaction of Major Histocompatibility Complex Class II-derived Peptides with Class Ia Phosphoinositide 3-Kinase Results in Dose-dependent Stimulatory Effects*

G. Panayotou, P. Shepherd, Lazaros C Foukas, 2004, Journal of Biological Chemistry.

eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.

P. Shepherd, L. Foukas, 2004, Biochemical and biophysical research communications.

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

B. Vanhaesebroeck, A. Khwaja, A. Gray, 2010, Proceedings of the National Academy of Sciences.

Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue

N. Alic, E. Schuster, L. Bettedi, 2020, Scientific Reports.

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

B. Vanhaesebroeck, W. Pearce, C. Scudamore, 2016, Diabetologia.

Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling

L. Foukas, Cheukyau Luk, Biqin Zhang, 2021, International journal of molecular sciences.

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

S. Schiffmann, S. Schurmans, B. Vanhaesebroeck, 2012, Cellular signalling.

Hemocyte surface phenoloxidase (PO) and immune response to lipopolysaccharide (LPS) in Ceratitis capitata.

C. G. Zervas, V. Marmaras, N. D. Charalambidis, 1996, Insect biochemistry and molecular biology.

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases.

K. Okkenhaug, L. Foukas, 2003, Archives of biochemistry and biophysics.

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.

P. Shepherd, C. Beeton, E. Chance, 2000, The Biochemical journal.

Covalent association of lipopolysaccharide at the hemocyte surface of insects is an initial step for its internalization--Protein-tyrosine phosphorylation requirement.

V. Marmaras, N. D. Charalambidis, L. Foukas, 1996, European journal of biochemistry.

Phagocytosis of Escherichia coli by Insect Hemocytes Requires Both Activation of the Ras/Mitogen-activated Protein Kinase Signal Transduction Pathway for Attachment and β3 Integrin for Internalization*

V. Marmaras, A. Metheniti, Haralabos L. Katsoulas, 1998, The Journal of Biological Chemistry.

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

K. Okkenhaug, B. Vanhaesebroeck, W. Pearce, 2006, Nature.

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

Holger Gerhardt, Christiana Ruhrberg, Pedro R. Cutillas, 2008, Nature.

Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo

W. Phillips, P. Shepherd, C. Beeton, 2004, Molecular and Cellular Biology.

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

P. Shepherd, K. Anderson, J. Jensen, 2002, The Journal of biological chemistry.

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases

P. Shepherd, C. Beeton, E. Chance, 2000 .

Signalling by PI3K isoforms: insights from gene-targeted mice.

A. Bilancio, B. Vanhaesebroeck, K. Ali, 2005, Trends in biochemical sciences.

Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

C. Dani, L. Bettedi, A. Vidal-Puig, 2019, Nature Communications.

Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue

N. Alic, E. Schuster, L. Bettedi, 2020, Scientific Reports.

Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing

L. Bettedi, L. Foukas, 2017, Biogerontology.

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations

S. O’Rahilly, M. Dattani, I. Barroso, 2016, JCI insight.

Phosphoinositide signalling pathways in metabolic regulation.

D. Withers, L. Foukas, 2010, Current topics in microbiology and immunology.

C. elegans feed yolk to their young in a form of primitive lactation

J. Bähler, G. Taylor, D. Gems, 2021, Nature Communications.

Phosphoinositide 3-kinase: the protein kinase that time forgot.

P. Shepherd, L. Foukas, 2004, Biochemical Society transactions.

C. elegans provide milk for their young

J. Bähler, G. Taylor, D. Gems, 2020, bioRxiv.

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

B. Vanhaesebroeck, W. Pearce, C. Scudamore, 2016, Diabetologia.

Direct Effects of Caffeine and Theophylline on p110δ and Other Phosphoinositide 3-Kinases

P. Shepherd, K. Anderson, J. Jensen, 2002, The Journal of Biological Chemistry.