J. Onorato

发表

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

D. Newby, D. Welsh, A. Peacock, 2018, JACC. Basic to translational science.

Immunochemical characterization of purified human oxidized low-density lipoprotein antibodies.

G. Krings, M. Lopes-Virella, G. Virella, 2000, Clinical immunology.

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

David S. Taylor, P. Sleph, L. Abell, 2018, ACS medicinal chemistry letters.

Applications of HILIC for targeted and non-targeted LC/MS analyses in drug discovery.

P. Shipkova, A. Bellamine, Robert A. Langish, 2010, Journal of separation science.

Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data

M. Jamieson, P. Gargalovic, C. Russ, 2022, American Journal of Cardiovascular Drugs.

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

P. Shipkova, A. Tymiak, A. Minnich, 2014, Journal of Lipid Research.

Immunohistochemical and ELISA Assays for Biomarkers of Oxidative Stress in Aging and Disease a

J. Baynes, S. Thorpe, J. Onorato, 1998, Annals of the New York Academy of Sciences.

Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data

M. Jamieson, P. Gargalovic, C. Russ, 2022, American Journal of Cardiovascular Drugs.

Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis.

A. D. Rodrigues, Z. Ouyang, F. LaCreta, 2011, Chemical research in toxicology.

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.

C. Chu, E. A. Brown, D. Gordon, 2022, Cell metabolism.

Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions

A. Jenkins, J. Baynes, S. Thorpe, 2000, The Journal of Biological Chemistry.

Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.

Steven A. Spronk, S. Jusuf, L. Abell, 2020, Bioorganic & medicinal chemistry.

Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.

Michael C. Myers, Rongan Zhang, P. Gargalovic, 2019, Analytical biochemistry.

Enantioselective liquid chromatography-mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma.

C. Walko, D. Siluk, C. Lindley, 2007, Journal of pharmaceutical and biomedical analysis.

Biphenyl Acid Derivatives as APJ Receptor Agonists.

Michael A. Galella, P. Gargalovic, D. Gordon, 2019, Journal of medicinal chemistry.

A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS(3).

Jennifer Wang, Jae Kwagh, P. Shipkova, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Paul J Thornalley, P. Beisswenger, M. Brownlee, 1998, The Journal of clinical investigation.

Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases[S]

Zhengping Ma, C. L. Yen, D. Cheng, 2017, Journal of Lipid Research.

Synthesis of [D4]- and [D7]-4β-hydroxycholesterols for use in a novel drug–drug interaction assay

S. Bonacorsi, J. Onorato, R. Burrell, 2012 .

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

David S. Taylor, Brandon L. Parkhurst, E. Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

David S. Taylor, Michael A. Galella, Hong Shen, 2018, Bioorganic & medicinal chemistry letters.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

David S. Taylor, Michael A. Galella, L. Abell, 2018, ACS medicinal chemistry letters.

Design and preparation of N-linked hydroxypyridine-based APJ agonists.

P. Gargalovic, D. Gordon, R. Wexler, 2022, Bioorganic & medicinal chemistry letters.

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

P. Gargalovic, M. Bouvier, D. Gordon, 2021, Circulation. Heart failure.

Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue

Zhengping Ma, P. Shipkova, A. Azzará, 2010, Analytical and bioanalytical chemistry.

Selected reaction monitoring LC-MS determination of idoxifene and its pyrrolidinone metabolite in human plasma using robotic high-throughput, sequential sample injection.

J. Henion, J. Kiplinger, J. Onorato, 2001, Analytical chemistry.

Qualified method for the estimation of di-18:1 bis(monoacylglycero)phosphate in urine, a noninvasive biomarker to monitor drug-induced phospholipidosis.

P. Kole, Bokka Venkata Murali, P. Rajanna, 2020, Bioanalysis.

Evaluation of triterpene glycoside estrogenic activity using LC/MS and immunoaffinity extraction.

J. Henion, J. Onorato, 2001, Analytical chemistry.

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Timothy Olah, Dieter M Drexler, Jonathan L Josephs, 2014, Analytical chemistry.

Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor

E. Janovitz, L. Abell, M. Tirmenstein, 2013, International journal of toxicology.

Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists.

P. Gargalovic, D. Gordon, R. Wexler, 2021, ACS medicinal chemistry letters.

Identification of 6-Hydroxy-5-phenylsulfonylpyrimidin-4(1H)-one APJ Receptor Agonists.

Michael A. Galella, P. Gargalovic, R. Wexler, 2021, Bioorganic & Medicinal Chemistry Letters.

Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.

P. Gargalovic, R. Wexler, Tao Wang, 2021, Journal of medicinal chemistry.

Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.

Michael C. Myers, A. Nayeem, P. Gargalovic, 2020, Bioorganic & medicinal chemistry letters.

Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.

Michael A. Galella, P. Gargalovic, Soong-Hoon Kim, 2021, Journal of medicinal chemistry.

Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions

A. Jenkins, J. Baynes, S. Thorpe, 2000, The Journal of Biological Chemistry.