J. Perchellet

发表

Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis.

D. VanderVelde, N. Brown, N. Markina, 2008, Bioorganic & medicinal chemistry letters.

Alterations in focal adhesion kinase activity and associated proteins during malignant conversion of mouse keratinocytes

E. Ulug, J. Perchellet, E. Perchellet, 1999, Molecular carcinogenesis.

Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities.

P. Chiang, Srinivas K. Battina, D. Hua, 2008, Bioorganic & medicinal chemistry.

Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.

G. Chen, J. Perchellet, E. Perchellet, 1996, Cancer letters.

Synthesis and in vitro antitumor activity of substituted anthracene-1,4-diones

T. Iwamoto, D. Hua, Kaiyan Lou, 2004 .

Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.

Justin L. Crossland, D. Hua, Kaiyan Lou, 2004, Biochemical pharmacology.

Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling

D. Hua, Kaiyan Lou, J. Perchellet, 2004, Anti-cancer drugs.

Preparation and cytotoxic activity of some new rhodomycin derivatives bearing modifications in the sugar moiety.

A. Skaltsounis, J. Florent, P. Marakos, 2002, The Journal of antibiotics.

Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro

D. Hua, M. Tamura, J. Perchellet, 2002, Anti-cancer drugs.

Synthetic 1,4-anthracenediones, which block nucleoside transport and induce DNA fragmentation, retain their cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines

D. Hua, B. Wang, H. Stephany, 2001, Anti-cancer drugs.

1,4-Anthraquinone: an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro

D. Hua, J. Perchellet, E. Perchellet, 2000, Anti-cancer drugs.

Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.

Srinivas K. Battina, D. Hua, Kaiyan Lou, 2007, Anticancer research.

Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria.

Srinivas K. Battina, D. Hua, Kaiyan Lou, 2007, International journal of oncology.

Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria.

Bernard Wiredu, Srinivas K. Battina, D. Hua, 2006, International journal of oncology.

Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones

D. Hua, Kaiyan Lou, M. M. Ward, 2005, Anti-cancer drugs.

Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin.

M. Boukharta, T. Hatano, T. Okuda, 1997, International journal of oncology.

Comparison of the Inhibitory Effects of Monomeric, Dimeric, and Trimeric Procyanidins on the Biochemical Markers of Skin Tumor Promotion in Mouse Epidermis in vivo

J. Karchesy, J. Perchellet, E. Perchellet, 1994, Planta medica.

Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion.

J. Perchellet, E. Perchellet, G. S. Kishore, 1985, Cancer letters.

Stimulation of hydroperoxide generation in mouse skins treated with tumor-promoting or carcinogenic agents in vivo and in vitro.

J. Perchellet, E. Perchellet, N. L. Abney, 1988, Cancer letters.

Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo.

J. Perchellet, E. Perchellet, D. Jones, 1990, Cancer research.

Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo.

J. Perchellet, E. Perchellet, H. Gali, 1991, Cancer research.

Inhibitory effects of semisynthetic flavonoid derivatives on the biochemical markers of tumor promotion in mouse epidermis in vivo.

P. Laks, J. Perchellet, E. Perchellet, 1993, Cancer letters.

Hydrolyzable tannins: Potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12‐O‐tetradecanoylphorbol‐13‐acetate in vivo

J. Perchellet, E. Perchellet, H. Gali, 1992, International journal of cancer.

Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin.

J. Perchellet, E. Perchellet, H. Gali, 1992, Basic life sciences.

Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters.

J. Perchellet, E. Perchellet, D. J. Orten, 1986, Carcinogenesis.

Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils.

S. Belman, J. Perchellet, E. Perchellet, 1990, Nutrition and cancer.

Development of the gubernaculum and processus vaginalis in freemartinism: Further evidence in support of a specific fetal testis hormone governing male‐specific gubernacular development

A. G. Gittenberger-de Groot, J. Perchellet, P. van der Schoot, 1995, The Anatomical record.

Inhibitory effects of glutathione level-raising agents and D-alpha-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

M. Owen, J. Perchellet, D. J. Orten, 1985, Carcinogenesis.

Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine.

K. Satyamoorthy, J. Perchellet, 1990, Cancer letters.

Structure-Activity Relationship Studies of a Novel CXCR4 Chemokine Antagonist Reveal Unique Activity Profile

T. Yakovleva, J. Perchellet, E. Perchellet, 2006 .

Syntheses and bioactivities of tricyclic pyrones

P. Chiang, D. Hua, H. Tomoda, 2003 .

Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo.

J. Perchellet, E. Perchellet, 1989, Cancer research.

Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

R. Boutwell, J. Perchellet, 1981, Cancer research.

Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells.

A. Skaltsounis, P. Marakos, N. Pouli, 2006, Anticancer research.

Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines.

D. Hua, M. Tamura, J. Perchellet, 2002, Cancer letters.

Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

K. Satyamoorthy, J. Perchellet, 1989, Cancer research.

A unique sialoglycopeptide growth regulator that inhibits mitogenic activity of a phorbol ester tumor promoter.

T. Johnson, C. Bascom, J. Perchellet, 1987, Cancer letters.

Ability of the non‐phorbol ester‐type tumor‐promoter thapsigargin to mimic the stimulatory effects of 12‐0‐tetradecanoylphorbol‐13‐acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis In vivo

J. Perchellet, E. Perchellet, X. Gao, 1993, International journal of cancer.

Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles.

Andrew M. Waters, K. Chandra, S. Rayat, 2010, Bioorganic & medicinal chemistry letters.

Effects of 3-lsobutyl-1-methylxanthine and Cyclic Nucleotides on 12-0-Tetradecanoylphorbol-13-acetate-induced Ornithine Decarboxylase Activity in Mouse Epidermis in Vivo1

R. Boutwell, J. Perchellet, 2006 .

Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate.

J. Perchellet, E. Perchellet, R. M. Thomas, 1987, Cancer research.

Effects of amino acid treatments on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo and in vitro.

E. A. Conrad, R. Boutwell, J. Perchellet, 1983, The Journal of investigative dermatology.

Regioselective lactonization of naphthoquinones: synthesis and antitumoral activity of the WS-5995 antibiotics

Graham B Jones, J. Perchellet, E. Perchellet, 2000 .

Mechanisms by which synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro.

G. Lushington, Benjamin Neuenswander, C. R. Singh, 2014, Anticancer research.

Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells.

P. Baures, J. Perchellet, E. Perchellet, 2005, Journal of medicinal chemistry.

Quinone isomers of the WS-5995 antibiotics: synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation, and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro

Graham B Jones, E M Perchellet, B J Sperfslage, 2001, Anti-cancer drugs.

A One-Pot Condensation of Pyrones and Enals. Synthesis of 1H,7H-5a,6,8,9-Tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans

J. Freeman, P. Chiang, D. Hua, 1997 .

Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro.

G. Lushington, Benjamin Neuenswander, P. Thornton, 2012, Anticancer research.

Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins.

G. Lushington, M. Minatoya, N. Brown, 2009, International journal of molecular medicine.

Synthesis and in vitro Antitumor Activity of Substituted Anthracene‐1,4‐diones.

T. Iwamoto, D. Hua, Kaiyan Lou, 2005 .

Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities

D. Hua, M. Tamura, J. Perchellet, 2003, Anti-cancer drugs.

Triptycenes: a novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro.

D. Hua, J. Perchellet, E. Perchellet, 1999, Anti-cancer drugs.

Ability of tannins extracted from the leaves of various trees and shrubs to inhibit the biomarkers of tumor promotion in mouse skin in vivo.

H. Makkar, J. Perchellet, E. Perchellet, 1996, International journal of oncology.

Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin.

J. Perchellet, E. Perchellet, R. M. Thomas, 1987, Cancer research.

Mediatory role of calcium and guanosine 3', 5'-monophosphate in adrenocorticotropin-induced steroidogenesis by adrenal cells.

J. Perchellet, R. Sharma, 1979, Science.

Studies on sex differentiation in mammals.

J. Perchellet, A. Jost, B. Vigier, 1973, Recent progress in hormone research.

Antioxidants and multistage carcinogenesis in mouse skin.

J. Perchellet, E. Perchellet, 1989, Free radical biology & medicine.

Regulatory role of guanosine 3',5'-monophosphate in adrenocorticotropin hormone-induced steroidogenesis.

G. Shanker, J. Perchellet, R. Sharma, 1978, Science.

Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation

R. E. Luna, E. Papadopoulos, C. Cox, 2016, Nucleic acids research.

Effects of adriamycin and daunomycin on ornithine decarboxylase activity and DNA synthesis in mouse epidermal cells.

K. Satyamoorthy, J. Perchellet, E. Perchellet, 1992, Toxicology in vitro : an international journal published in association with BIBRA.

Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12‐O‐tetradecanoylphorbol‐13‐acetate

J. Perchellet, E. Perchellet, N. L. Abney, 1987, Journal of cellular physiology.

Antitumor-promoting activities of hydrolyzable tannins in mouse skin.

J. M. Johnson, J. Perchellet, E. Perchellet, 1992, Carcinogenesis.

Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro.

Aibin Shi, D. Hua, T. Nguyen, 2010, International journal of oncology.

Characterization of the antitumor-promoting activity of camptothecin in SENCAR mouse skin.

D. Hua, J. Perchellet, E. Perchellet, 1996, Carcinogenesis.

Characterization of the tumor-promoting activity of thapsigargin in cf-1 mouse skin.

G. Chen, J. Perchellet, E. Perchellet, 1994, International journal of oncology.

Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach.

G. Lushington, M. Minatoya, D. VanderVelde, 2008, Journal of combinatorial chemistry.

Antitumor activity of novel octalactin A analogs in murine leukemia cells in vitro.

J. Freeman, N. Sato, J. Perchellet, 1998, Anticancer research.

Inhibition of ultraviolet-B radiation induced ornithine decarboxylase activity and edema formation by hydrolyzable and condensed tannins in mouse skin in vivo.

H. Gali-Muhtasib, J. Perchellet, S. Khatib, 1997, Anticancer research.

Antitumor-promoting effects of gallotannins extracted from various sources in mouse skin in vivo.

J. Perchellet, E. Perchellet, X. Gao, 1993, Anticancer research.

Characterization of the tumor-promoting activity of m-chloroperoxybenzoic acid in SENCAR mouse skin and its inhibition by gallotannin, oligomeric proanthocyanidin, and their monomeric units.

R. Hemingway, G. Chen, F. Johnson, 1996, International journal of oncology.

Ability of m-chloroperoxybenzoic acid to induce the ornithine decarboxylase marker of skin tumor promotion and inhibition of this response by gallotannins, oligomeric proanthocyanidins, and their monomeric units in mouse epidermis in vivo.

R. Hemingway, G. Chen, J. Perchellet, 1995, Anticancer research.

Antitumor-promoting activity of oligomeric proanthocyanidins in mouse epidermis in-vivo.

R. Hemingway, J. Perchellet, E. Perchellet, 1994, International journal of oncology.

Diethyldithiocarbamate Inhibition of Multistage Tumor Promotion in Mouse Skin by Updated

Ryan M. Thomas, J. Perchellet, E. Perchellet, 2006 .

ANTITUMOR-PROMOTING ACTIVITY OF DDTC metabolisms in mouse epidermis and since the treatments with vitamin

Ryan M. Thomas, J. Perchellet, E. Perchellet, 2006 .

Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate.

J. Perchellet, E. Perchellet, R. M. Thomas, 1987, Cancer research.

Antitumor-promoting effects of gallotannins, ellagitannins, and flavonoids in mouse skin in vivo

A. Scalbert, P. Laks, R. Hemingway, 1994 .

Effects of garlic and onion oils on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione and ornithine decarboxylase induction in isolated mouse epidermal cells treated with tumor promoters.

S. Belman, J. Zirnstein, J. Perchellet, 1986, Cancer biochemistry biophysics.

Inhibition of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds.

J. Perchellet, E. Perchellet, D. J. Orten, 1985, Cancer letters.

Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo.

R. Boutwell, J. Perchellet, 1981, Cancer research.

Stimulation of guanosine 3',5'-monophosphate-phosphodiesterase activity by adrenocorticotropic hormone-activated increase of guanosine 3',5'-monophosphate in isolated adrenocortical carcinoma cells.

R. Sharma, J. Perchellet, 1979, Endocrinology.

Metabolic regulation of steroidogenesis in isolated adrenocortical carcinoma cells. ACTH regulation of guanosine cyclic 3' :5' - monophosphate levels.

R. Sharma, J. Perchellet, 1977, Biochemical and biophysical research communications.

Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines.

P. Chiang, D. Kyle, D. Hua, 2002, The Journal of organic chemistry.

A synthetic triptycene bisquinone, which blocks nucleoside transport and induces DNA fragmentation, retains its cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines.

D. Hua, B. Wang, M. Tamura, 2001, International journal of oncology.

Comparison of the inhibitory effects of diverse amino acids and amino acid analogs on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in isolated epidermal cells.

J. Perchellet, M. D. Owen, T. Posey, 1985, Biochimica et biophysica acta.

Effects of cell surface receptor-altering agents on the binding and biological activity of 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells.

E. A. Conrad, R. Boutwell, J. Perchellet, 1982, Carcinogenesis.

Comparison of the effects of 3-isobutyl-1-methylxanthine and adenosine cyclic 3':5'-monophosphate on the induction of skin tumors by the initiation-promotion protocol and by the complete carcinogenesis process.

R. Boutwell, J. Perchellet, 1982, Carcinogenesis.

Enhancement by 3-isobutyl-1-methylxanthine and cholera toxin of 12-O-tetradecanoylphorbol-13-acetate-stimulated cyclic nucleotide levels and ornithine decarboxylase activity in isolated epidermal cells.

R. Boutwell, J. Perchellet, 1980, Cancer Research.

Camptothecin post‐treatments inhibit the biochemical events linked to the tumor‐promoting component of carcinogenesis in mouse epidermis in vivo

D. Hua, J. Perchellet, E. Perchellet, 1996, International journal of cancer.

Inhibitory Effects of Plant Tannins on Ultraviolet Light‐Induced Epidermal DNA Synthesis in Hairless Mice

H. Gali-Muhtasib, J. Perchellet, Jean‐Pierre Perchellet, 1998, Photochemistry and photobiology.

Total syntheses of (+)-chloropuupehenone and (+)-chloropuupehenol and their analogues and evaluation of their bioactivities.

Srinivas K. Battina, D. Hua, H. Tomoda, 2004, Journal of Organic Chemistry.

The Prenatal Development of Bovine Freemartins

J. Perchellet, A. Jost, B. Vigier, 1975 .

Microtubule-disrupting effects of gallium chloride in vitro.

J. Perchellet, E. Perchellet, P. Collery, 1999, Anti-cancer drugs.

Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis.

D. VanderVelde, N. Brown, N. Markina, 2008, Bioorganic & medicinal chemistry letters.