G. J. Lockbaum

发表

HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands to Optimize Hydrogen Bonding in the Substrate Envelope.

Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali, 2019, Journal of medicinal chemistry.

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

Shuntai Zhou, C. Schiffer, R. Swanstrom, 2019, bioRxiv.

pM to µM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.

Shuntai Zhou, C. Schiffer, D. Bolon, 2019, ACS chemical biology.

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

C. Schiffer, E. Nalivaika, Akbar Ali, 2018, bioRxiv.

Inhibiting HTLV-1 Protease: A Viable Antiviral Target.

C. Schiffer, E. Nalivaika, M. Somasundaran, 2021, ACS chemical biology.

Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV ‑ 1 Protease in Conferring Drug Resistance

D. Bolon, R. Swanstrom, E. Nalivaika, 2019 .

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

C. Schiffer, E. Nalivaika, Akbar Ali, 2021, Chemical reviews.

Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2

Jeong Min Lee, C. Schiffer, P. Thompson, 2022, Journal of the American Chemical Society.

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

C. Schiffer, D. Bolon, J. Flynn, 2022, Nature Communications.

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

C. Schiffer, Akbar Ali, Adam K. Hedger, 2020, mBio.

Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.

C. Schiffer, C. Petropoulos, Wei Huang, 2018, ACS medicinal chemistry letters.

Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses

C. Schiffer, W. Marasco, R. Finberg, 2021, Nature Communications.

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

C. Schiffer, J. Lee, E. Nalivaika, 2021, Viruses.

Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode

C. Schiffer, J. Lee, E. Nalivaika, 2021, Biochemistry.

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

C. Schiffer, E. Nalivaika, Akbar Ali, 2018, ACS infectious diseases.

Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures.

C. Schiffer, W. Royer, Nese Kurt Yilmaz, 2020, Acta crystallographica. Section D, Structural biology.

HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2023, European journal of medicinal chemistry.

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2020, Journal of medicinal chemistry.

Molecular determinants of epistasis in HIV-1 protease: Elucidating the interdependence of L89V and L90M mutations in resistance.

C. Schiffer, D. Bolon, T. Whitfield, 2019, Biochemistry.