Yuxi Wang

发表

Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design

Kai Chen, Guo‐Bo Li, Shan Liu, 2017 .

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.

L. Zhong, Guo‐Bo Li, Ling-Ling Yang, 2018, European journal of medicinal chemistry.

Synthesis, characterization, and antitumor evaluation of the albumin–SN38 conjugate

Yongmei Xie, L. Gou, Yuqin Yao, 2013, Anti-cancer drugs.

Structure-based development of human antibody cocktails against SARS-CoV-2

Xiangxi Wang, Yongqiang Deng, F. Zhu, 2020, Cell research.

Combination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma

Xiaohua Jiang, Cheng Huang, L. Gou, 2021, Frontiers in Cell and Developmental Biology.

Targeting of DDR1 with antibody‐drug conjugates has antitumor effects in a mouse model of colon carcinoma

Xiaohua Jiang, Tinghan Yang, L. Gou, 2019, Molecular oncology.

High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.

Bo Sun, Chengyong Wu, Yuxi Wang, 2020, Biochemical and biophysical research communications.

A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin

Chengyong Wu, Yuxi Wang, Yiran Tao, 2021, Molecules.

Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.

Duane D. Miller, S. White, G. Kumar, 2018, Journal of medicinal chemistry.

A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution

Kaixiang Zhang, Ruijie Deng, Xucong Teng, 2022, Nature Biomedical Engineering.

Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by in silico affinity maturation and SPR assay

Tianyuan Wang, Yalun Li, Weikun Wu, 2020, bioRxiv.

Detection of SARS-CoV-2 and Its Mutated Variants via CRISPR-Cas13-Based Transcription Amplification

Kaixiang Zhang, Ruijie Deng, Yalun Li, 2021, Analytical chemistry.

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities.

Shuwen Liu, M. Luo, Ling-Wei Li, 2020, European journal of medicinal chemistry.

Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies.

Xiaohua Jiang, L. Gou, Yuqin Yao, 2020, European journal of medicinal chemistry.

Isothermal RNA Amplification for the Detection of Viable Pathogenic Bacteria to Estimate the Salmonella Virulence for Causing Enteritis.

Kaixiang Zhang, Ruijie Deng, Xinyue Hu, 2022, Journal of agricultural and food chemistry.

Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines

Tinghan Yang, Jiong Li, Hongwei Xia, 2016, Journal of Molecular Medicine.

Pharmacokinetic properties of wogonin and its herb-drug interactions with docetaxel in rats with mammary tumors.

Kai Cheng, Yuxi Wang, H. Cai, 2018, Biomedical chromatography : BMC.

Two-photon ratiometric fluorescent probe for imaging of hypochlorous acid in acute lung injury and its remediation effect.

Q. Lei, Zixuan Zhan, Y. Lv, 2021, Analytica chimica acta.

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Yiguo Hu, Sheng-yong Yang, Peng Bai, 2018, Cellular Physiology and Biochemistry.

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin

T. Yang, F. Wang, Heying Pei, 2018, The Journal of Biological Chemistry.

Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy

L. Ouyang, Fengbo Wu, Jifa Zhang, 2022, Journal of Hematology & Oncology.

Synthesis, characterization and targeting chemotherapy for ovarian cancer of trastuzumab-SN-38 conjugates.

Yuquan Wei, B. Zhang, Yongmei Xie, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Structure Activity Relationships Study of Novel 6 Aryl-2-Benzoyl-Pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.

Duane D. Miller, S. White, G. Kumar, 2019, Journal of medicinal chemistry.

FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma

Yuehua Wu, Xiaohua Jiang, Fanxin Ma, 2022, Journal of Hematology & Oncology.

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.

Duane D. Miller, F. Park, J. Dalton, 2018, Cancer research.

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

B. Gigant, Yamei Yu, Yuxi Wang, 2016, The FEBS journal.

Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate.

Xiaohua Jiang, L. Ouyang, Wei Zhou, 2022, Journal of medicinal chemistry.

Polymorphs, co-crystal structure and pharmacodynamics study of MBRI-001, a deuterium-substituted plinabulin derivative as a tubulin polymerization inhibitor.

Shixiao Wang, Yuxi Wang, Jinliang Yang, 2019, Bioorganic & medicinal chemistry.

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.

Duane D. Miller, S. White, G. Kumar, 2018, Journal of medicinal chemistry.

Metabolic Reprogramming of Terminally Exhausted CD8+ T cells by IL-10 Enhances Anti-Tumor Immunity

P. Romero, Ping-Chih Ho, A. Chaiboonchoe, 2021, Nature Immunology.

Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.

L. Gou, Yuqin Yao, Hao Chen, 2018, European journal of medicinal chemistry.

Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy.

Duane D. Miller, L. Ouyang, Guan Wang, 2021, Journal of medicinal chemistry.

SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.

Duane D. Miller, B. Meibohm, S. White, 2022, Cancer letters.

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

J. Naismith, C. Botting, Lijuan Chen, 2016, Nature Communications.

CRISPR-Cas13a cascade-based viral RNA assay for detecting SARS-CoV-2 and its mutations in clinical samples

Ruijie Deng, Yalun Li, R. Ledesma-Amaro, 2022, Sensors and Actuators B: Chemical.

Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Peng Li, Xiaoxin Chen, Chaofeng Long, 2020, Acta pharmaceutica Sinica. B.

Mechanism of microtubule stabilization by taccalonolide AJ

B. Gigant, Yamei Yu, Hao Chen, 2017, Nature Communications.

Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models

Xiaoxin Chen, L. Gou, Shijie Zhou, 2018, Journal of drug targeting.

Promiximab-duocarmycin, a new CD56 antibody-drug conjugates, is highly efficacious in small cell lung cancer xenograft models

Ligong Chen, L. Gou, Yuqin Yao, 2017, Oncotarget.

Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling

Yangfu Jiang, C. Yi, Yan Zhou, 2012, Journal of Molecular Medicine.

CA II, a potential biomarker by proteomic analysis, exerts significant inhibitory effect on the growth of colorectal cancer cells.

Xia Zhao, A. Tong, Ming-hai Tang, 2013, International journal of oncology.

Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy

Duane D. Miller, Zhe-Sheng Chen, S. White, 2019, Molecular Pharmacology.

Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms

Xiangxi Wang, Yao Sun, Weimin Li, 2021, Cell Research.

Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.

Guiping Zhang, Weimin Li, Chengyong Wu, 2020, Biochemical and biophysical research communications.

Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers.

L. Ouyang, Guan Wang, F. Lin, 2021, Journal of medicinal chemistry.

Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling

Yangfu Jiang, Cheng Yi, C. Yi, 2012, Journal of Molecular Medicine.

X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.

Duane D. Miller, B. Meibohm, S. White, 2021, Journal of medicinal chemistry.

X-Ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors.

Duane D. Miller, Wei Li, Weimin Li, 2019, ACS chemical biology.

Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling

Tinghan Yang, Weiyong Xu, Yonghui Zhang, 2016, Journal of cachexia, sarcopenia and muscle.

Preparation and characterization of a high-affinity monoclonal antibody against human epididymis protein-4.

Xiaohua Jiang, Q. Peng, Yuqin Yao, 2018, Protein expression and purification.

Analytical tools for antibody–drug conjugates: from in vitro to in vivo

Ruijie Deng, Ya Zhang, Yuxi Wang, 2022, TrAC Trends in Analytical Chemistry.

Eradication of Growth of HER2-Positive Ovarian Cancer With Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate in Mouse Xenograft Model

Yongmei Xie, C. Yi, L. Gou, 2014, International Journal of Gynecologic Cancer.

Expression of 5T4 extracellular domain fusion protein and preparation of anti-5T4 monoclonal antibody with high affinity and internalization efficiency.

Xiaohua Jiang, Yan Zhou, L. Gou, 2019, Protein expression and purification.

A novel 5T4-targeting antibody-drug conjugate H6-DM4 exhibits potent therapeutic efficacy in gastrointestinal tumor xenograft models.

Tinghan Yang, L. Gou, Yuqin Yao, 2018, American journal of cancer research.

Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.

Jianjun Chen, Yuxi Wang, Yichang Ren, 2021, Journal of medicinal chemistry.

Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer.

L. Ouyang, Guan Wang, Aoxue Wang, 2023, Journal of medicinal chemistry.

Recent Advances in Cardiovascular Disease Biosensors and Monitoring Technologies.

Ruijie Deng, Yuxi Wang, Lichao Tang, 2023, ACS sensors.

Development of novel phenoxy-diketopiperazine-type plinabulin derivatives as potent antimicrotubule agents based on the co-crystal structure.

Cai Song, Shixiao Wang, Yan-yan Chu, 2019, Bioorganic & medicinal chemistry.

Enzyme-free amplified and ultrafast detection of aflatoxin B1 using dual-terminal proximity aptamer probes.

Kaixiang Zhang, Qiang He, Ruijie Deng, 2019, Food chemistry.

Eradication of large established tumors by drug-loaded bacterial particles via a neutrophil-mediated mechanism.

Hanshuo Yang, Qi-qi Li, Yuxi Wang, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Therapeutic potential of an anti-HER2 single chain antibody–DM1 conjugates for the treatment of HER2-positive cancer

Xiaohua Jiang, Min Wu, L. Gou, 2017, Signal Transduction and Targeted Therapy.

Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines

Tinghan Yang, Jiong Li, Hongwei Xia, 2016, Journal of Molecular Medicine.

C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.

Yuxi Wang, Jinliang Yang, Minhao Huang, 2021, Biochemical and biophysical research communications.

Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules

Qisheng Wang, Yonghui Zhang, Huiyan Li, 2016, Molecular Pharmacology.

Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules s

Qisheng Wang, Yonghui Zhang, Huiyan Li, 2016 .

Structure guided design, synthesis, and biological evaluation of 2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) analogs targeting the colchicine binding site in tubulin.

Duane D. Miller, S. White, Wei Li, 2019, Journal of medicinal chemistry.

Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.

Xiaohua Jiang, Yamei Yu, Chengyong Wu, 2017, Biochemical and biophysical research communications.

Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.

Yamei Yu, Chengyong Wu, Yuxi Wang, 2018, Biochemical and biophysical research communications.