Qiang Chen

发表

Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design

Kai Chen, Guo‐Bo Li, Shan Liu, 2017 .

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.

L. Zhong, Guo‐Bo Li, Ling-Ling Yang, 2018, European journal of medicinal chemistry.

Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms

T. Yang, Zhuang Yang, Ming-hai Tang, 2022, Blood Cancer Journal.

Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase.

Lin Li, W. Xu, Ling-Ling Yang, 2019, MedChemComm.

Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.

Dingguo Xu, L. Ouyang, Heying Pei, 2022, Journal of medicinal chemistry.

A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage

Yinglan Zhao, Youfu Luo, Yue Zhou, 2022, MedComm – Oncology.

Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells

S. Yao, Qiang Chen, Junyan Qu, 2022, Nucleic acids research.

Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-Lactamases.

Q. Ma, Yong Wu, Y. Lei, 2019, Journal of medicinal chemistry.

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Yiguo Hu, Sheng-yong Yang, Peng Bai, 2018, Cellular Physiology and Biochemistry.

Expanding PAM recognition and enhancing base editing activity of Cas9 variants with non‐PI domain mutations derived from xCas9

S. Yao, Lifang Xie, Qiang Chen, 2022, The FEBS journal.

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.

Yongxiang Zheng, Yong Wu, Shan Liu, 2018, European journal of medicinal chemistry.

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.

Duane D. Miller, F. Park, J. Dalton, 2018, Cancer research.

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

B. Gigant, Yamei Yu, Yuxi Wang, 2016, The FEBS journal.

WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

Min Li, S. Yao, Yamei Yu, 2022, Signal Transduction and Targeted Therapy.

Targeting Pin1 by inhibitor API‐1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development

Yong Peng, Wenchen Pu, Yu-Quan Wei, 2018, Hepatology.

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

J. Naismith, C. Botting, Lijuan Chen, 2016, Nature Communications.

A split cytosine deaminase architecture enables robust inducible base editing

S. Yao, Lifang Xie, J. Long, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis

T. Fu, S. Yao, Haihuai He, 2021, Nucleic acids research.

Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux

Yuquan Wei, Jiang Lan, E. Nice, 2018, Autophagy.

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.

Xianming Deng, C. Benes, Ting Zhang, 2018, Cancer research.

Mechanism of microtubule stabilization by taccalonolide AJ

B. Gigant, Yamei Yu, Hao Chen, 2017, Nature Communications.

Preparation and anti-cancer evaluation of promiximab-MMAE, an anti-CD56 antibody drug conjugate, in small cell lung cancer cell line xenograft models

Xiaoxin Chen, L. Gou, Shijie Zhou, 2018, Journal of drug targeting.

Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy

Duane D. Miller, Zhe-Sheng Chen, S. White, 2019, Molecular Pharmacology.

sgBE: a structure-guided design of sgRNA architecture specifies base editing window and enables simultaneous conversion of cytosine and adenosine

S. Yao, Qiang Chen, Lifang Zhou, 2020, Genome biology.

Structural insights into the design of indole derivatives as tubulin polymerization inhibitors

Lijuan Chen, Yamei Yu, Qiang Chen, 2020, FEBS letters.

A distinct structure of Cas1-Cas2 complex provides insights into the mechanism for the longer spacer acquisition in Pyrococcus furiosus.

S. Yao, Haihuai He, Yamei Yu, 2021, International journal of biological macromolecules.

DCLK1 autoinhibition and activation in tumorigenesis

R. Thorne, A. Tong, Zhongwei Cao, 2021, Innovation.

Structure‐based discovery of new selective small‐molecule sirtuin 5 inhibitors

Ling-Ling Yang, Yong Wu, Shan Liu, 2018, Chemical biology & drug design.

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Rong Xiang, Shen-Zhen Huang, Sheng-Yong Yang, 2017, Chemical biology & drug design.

A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinoma.

Lei Tao, Yinglan Zhao, Youfu Luo, 2022, European journal of medicinal chemistry.

Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.

Na Sang, Lei Tao, Yinglan Zhao, 2020, Journal of medicinal chemistry.

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode

Yinglan Zhao, Youfu Luo, Z. Zuo, 2019, FEBS open bio.

Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain.

Yamei Yu, Linna Cheng, Qiang Chen, 2015, Acta crystallographica. Section F, Structural biology communications.

Discovery of a Prenylated Flavonol Derivative as a Pin1 Inhibitor to Suppress Hepatocellular Carcinoma by Modulating MicroRNA Biogenesis.

Sheng-yong Yang, Wenchen Pu, Yu Zheng, 2018, Chemistry, an Asian journal.

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity

Lijuan Chen, Wei-Qun Yan, Yamei Yu, 2019, The Journal of Biological Chemistry.

Structural basis for the self-recognition of sDSCAM in Chelicerata

Yongfeng Jin, Yamei Yu, Xi Zheng, 2023, Nature communications.

Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.

Yan Fan, Sheng-yong Yang, R. Xiang, 2021, European journal of medicinal chemistry.

Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.

Xiaohua Jiang, Yamei Yu, Chengyong Wu, 2017, Biochemical and biophysical research communications.

Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.

Yamei Yu, Chengyong Wu, Yuxi Wang, 2018, Biochemical and biophysical research communications.

Targeted, programmable, and precise tandem duplication in the mammalian genome.

S. Yao, Lifang Xie, Qiang Chen, 2023, Genome research.

Microtubule‐targeting agents for cancer treatment: Seven binding sites and three strategies

B. Gigant, Xi Zheng, Qiang Chen, 2023, MedComm – Oncology.

The Structure of MT189-Tubulin Complex Provides Insights into Drug Design

Wenyue Zheng, T. Meng, Yamei Yu, 2019, Letters in Drug Design & Discovery.

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.

Yongxiang Zheng, Yong Wu, Shan Liu, 2018, European journal of medicinal chemistry.