A. Lewis

发表

Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung.

P. Hayes, C. Wolf, J. Hayes, 1988, Carcinogenesis.

The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.

J. Griffiths, P. Workman, E. Aboagye, 1998, British Journal of Cancer.

Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.

J. Griffiths, P. Workman, E. Aboagye, 1997, Cancer research.

Glutathione-dependent enzyme expression in drug resistance

A. Lewis, 1988 .

Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues

B. Sikic, D. Lau, G. Duran, 1996, Cancer Chemotherapy and Pharmacology.

Induction and suppression of glutathione transferases by interferon in the mouse.

David John Adams, F. Balkwill, C. Wolf, 1987, The Journal of biological chemistry.

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects.

C. Wolf, J. Hayes, A. Lewis, 1988, Carcinogenesis.

The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.

A. Giaccia, J. Brown, N. Denko, 1991, Cancer research.

Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554).

P. Workman, E. Aboagye, A. Lewis, 1997, Biochemical pharmacology.

Cellular heterogeneity and drug resistance in two ovarian adenocarcinoma cell lines derived from a single patient

C. Wolf, C. Wolf, J. Smyth, 1987, International journal of cancer.

Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

A. Harris, C. Wolf, C. Robson, 1987, Cancer research.

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines.

A. Harris, C. Wolf, J. Hayes, 1989, British Journal of Cancer.

DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours.

A. Maran, E. Hamilton, M. Idoate, 1997, British Journal of Cancer.

Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours--evaluation of a potentially effective clinical therapy.

S. Barnett, S. Brown, A. Maclean, 1996, British Journal of Cancer.

The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554.

P. Workman, E. Aboagye, K. Ryan, 1996, Anti-cancer drug design.

The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis.

P. Workman, E. Aboagye, I. M. Huxham, 1995, British Journal of Cancer.

Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma.

P. Workman, E. Aboagye, M. Graham, 1995, Journal of chromatography. B, Biomedical applications.

Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.

P. Workman, F. Friedlos, S. Chen, 1995, Molecular pharmacology.

What role do glutathione S-transferases play in the cellular response to ionizing radiation?

A. Giaccia, J. Brown, A. Lewis, 1992, International journal of radiation oncology, biology, physics.

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.

P. Workman, P Workman, R Rampling, 1994, International journal of radiation oncology, biology, physics.

Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction.

P. Workman, I. Stratford, C. Moody, 1994, Anti-cancer drugs.

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.

P. Workman, G. R. Fisher, L. H. Patterson, 1998, Biochemical pharmacology.

Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin.

B. Sikic, D. Lau, A. Lewis, 1991, Cancer research.

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

M. Grever, K. Paull, P. Workman, 1996, Journal of the National Cancer Institute.

Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase

P. Workman, V. Brunton, A. Lewis, 1998, Cancer Chemotherapy and Pharmacology.

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.

A. Harris, C. Wolf, C. Robson, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Sensitization of drug resistant human ovarian cancer cells to cyanomorpholino doxorubicin (MRA-CN) by modulation of glutathione metabolism.

B. Sikic, D. Lau, G. Duran, 1992, International journal of radiation oncology, biology, physics.

Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin‐sensitive (A2780) and ‐resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis

M. Gaze, P. Workman, J. Plumb, 1994, International journal of cancer.

Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.

P. Workman, R. Riley, A. Lewis, 1994, Carcinogenesis.

Uptake and distribution of N-acetylcysteine in mice: tissue-specific effects on glutathione concentrations.

C. Wolf, L. McLellan, A. Lewis, 1995, Carcinogenesis.

The role of glutathione in determining the response of normal and tumor cells to anticancer drugs.

C. Wolf, J. Carmichael, D. Adams, 1987, Biochemical Society transactions.

Glutathione-S-transferases pi, alpha, mu and mdr1 mRNA expression in normal lymphocytes and chronic lymphocytic leukemia.

B. Sikic, O. Legrand, A. Faussat, 1995, Leukemia.

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.

P. Workman, J. Hartley, F. Friedlos, 1997, British Journal of Cancer.

Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species.

P. Workman, G. R. Fisher, L. H. Patterson, 2001, Biochemical pharmacology.

Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes.

B. Sikic, C. Wolf, D. Lau, 1992, Cancer research.

Association of DNA cross-linking with potentiation of the morpholino derivative of doxorubicin by human liver microsomes.

B. Sikic, D. Lau, A. Lewis, 1989, Journal of the National Cancer Institute.