P. E. Hanna

发表

N-acetyltransferases, O-acetyltransferases, and N,O-acetyltransferases: enzymology and bioactivation.

P. E. Hanna, 1994, Advances in pharmacology.

Metabolic Activation and Detoxification of Arylamines

P. E. Hanna, 1996, Current Medicinal Chemistry.

Involvement of thioredoxin in sulfoxide reduction by mammalian tissues.

J. Fuchs, M. W. Anders, P. E. Hanna, 1980, Biochemical and biophysical research communications.

Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases: bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene.

C. Wagner, P. E. Hanna, K. R. Sticha, 1998, Biochemical pharmacology.

Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein.

P. E. Hanna, K. R. Sticha, C. Bergstrom, 1997, Protein expression and purification.

Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2.

C. Wagner, K. Walters, Naixia Zhang, 2007, Chemical research in toxicology.

Hepatic N-acetyltransferases: selective inactivation in vivo by a carcinogenic N-arylhydroxamic acid.

T. Smith, P. E. Hanna, 1988, Biochemical pharmacology.

Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes.

C. Wagner, Haiqing Wang, P. E. Hanna, 2005, Chemical research in toxicology.

Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.

C. Wagner, Zhijun Guo, P. E. Hanna, 2004, Chemical research in toxicology.

Effect of group-selective modification reagents on arylamine N-acetyltransferase activities.

H. Cheon, P. E. Hanna, 1992, Biochemical pharmacology.

An isozyme-selective affinity label for rat hepatic acetyltransferases.

M. Wick, P. E. Hanna, H. Yeh, 1990, Biochemical pharmacology.

Bioactivation of N-arylhydroxamic acids by rat hepatic N-acetyltransferase. Detection of multiple enzyme forms by mechanism-based inactivation.

M. Wick, P. E. Hanna, 1990, Biochemical pharmacology.

The mercapturic acid pathway

M. W. Anders, P. E. Hanna, 2019, Critical reviews in toxicology.

Conformationally restricted analogs of histamine H1 receptor antagonists. 2-Phenyl- and 2-benzyl-1,2,3,4-tetrahydro-4-dimethylaminoisoquinoline.

M. W. Anders, P. E. Hanna, V. Grund, 1974, Journal of Medicinal Chemistry.

18-Crown-6 as a catalyst in the dialkylation of o-nitrophenacyl derivatives

S. Venkatraman, W. Noland, P. E. Hanna, 1991 .

CONFORMATIONALLY RESTRICTED ANALOGS OF HISTAME H1 RECEPTOR ANTAGONISTS, 2-PHENYL- AND 2-BENZYL-1,2,3,4-TETRAHYDRO-4-DIMETHYLAMINOISOQUINOLINE

M. W. Anders, P. E. Hanna, V. Grund, 1975 .

Irreversible inhibition of rat hepatic transacetylase activity by N-arylhydroxamic acids.

M. Wick, P. E. Hanna, I. Jantan, 1988, Biochemical pharmacology.

Arylhydroxamic acid N,O-acyltransferase. Apparent suicide inactivation by carcinogenic N-arylhydroxamic acids.

P. E. Hanna, R. Banks, 1979, Biochemical and biophysical research communications.

Phosphodiesterase inhibition by papaverine and structurally related compounds.

P. E. Hanna, N. D. Goldberg, R. O'dea, 1972, Biochemical pharmacology.

Substituent effects on the bioactivation of 2-(N-hydroxyacetamido)fluorenes by N-arylhydroxamic acid N,O-acyltransferase.

A. Elfarra, P. E. Hanna, 1985, Journal of medicinal chemistry.

Arylhydroxamic acid bioactivation via acyl group transfer. Structural requirements for transacylating and electrophile-generating activity of N-(2-fluorenyl)hydroxamic acids and related compounds.

P. E. Hanna, H. Yeh, 1982, Journal of medicinal chemistry.

Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines.

C. Wagner, Carston R Wagner, Patrick E Hanna, 2008, Chemical research in toxicology.

Probing the catalytic potential of the hamster arylamine N‐acetyltransferase 2 catalytic triad by site‐directed mutagenesis of the proximal conserved residue, Tyr190

C. Wagner, K. Walters, Naixia Zhang, 2009, The FEBS journal.

Arylamine N-acetyltransferase I.

R. Minchin, N. Butcher, C. Wagner, 2007, The international journal of biochemistry & cell biology.

NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity.

C. Wagner, Fen Liu, K. Walters, 2006, Journal of molecular biology.

Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation.

D. Koepp, C. Wagner, Fen Liu, 2006, Journal of molecular biology.

Catalytic mechanism of hamster arylamine N-acetyltransferase 2.

C. Wagner, Haiqing Wang, P. E. Hanna, 2005, Biochemistry.

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.

C. Wagner, E. Sim, A. Kawamura, 2005, Biochemical pharmacology.

Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies.

C. Wagner, Haiqing Wang, G. M. Vath, 2004, Biochemistry.

Cyclic hydroxamic acid inhibitors of prostate cancer cell growth: Selectivity and structure activity relationships

K. P. Roberts, R. Iyer, P. E. Hanna, 1998, The Prostate.

Analogues of N-hydroxy-4-acetylaminobiphenyl as substrates and inactivators of hamster hepatic acetyltransferases.

P. E. Hanna, A. EL-Ghandour, M. E. McCormack, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Thioredoxin-dependent sulfoxide reduction by rat renal cytosol.

J. Fuchs, M. W. Anders, P. E. Hanna, 1981, Drug metabolism and disposition: the biological fate of chemicals.

Sulfoxide reduction. In vitro reduction of sulindac by rat hepatic cytosolic enzymes.

M. W. Anders, D. E. Duggan, P. E. Hanna, 1981, Drug metabolism and disposition: the biological fate of chemicals.

Microsomal N-hydroxylation of trans-4'-alkoxy-4-acetamidostilbenes.

M. W. Anders, R. Gammans, P. E. Hanna, 1978, Drug metabolism and disposition: the biological fate of chemicals.

Affinity alkylation of hamster hepatic arylamine N-acetyltransferases: isolation of a modified cysteine residue.

H. Cheon, P. E. Hanna, L. Boteju, 1992, Molecular pharmacology.

N-acetyltransferase multiplicity and the bioactivation of N-arylhydroxamic acids by hamster hepatic and intestinal enzymes.

T. Smith, P. E. Hanna, 1986, Carcinogenesis.

Over-expression, Purification, and Characterization of Recombinant Human Arylamine N-Acetyltransferase 1

C. Wagner, Haiqing Wang, E. Sim, 2005, The protein journal.

Inactivation of hamster monomorphic N-acetyltransferase by vinyl fluorenyl ketone.

M. Wick, P. E. Hanna, 1994, Biochemical pharmacology.

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.

C. Wagner, P. E. Hanna, L. Liu, 2009, Chemical research in toxicology.

3‐Amino‐5‐phenyl‐1‐(2‐pyridyl)pyrrolidines. Synthesis and stereochemistry

P. E. Hanna, 1973 .

Conformationally restricted analogs of histamine H1 receptor antagonists. Trans- and cis-1,5-Diphenyl-3-dimethylaminopyrrolidine.

A. E. Ahmed, P. E. Hanna, 1973, Journal of Medicinal Chemistry.

1,5-diphenyl-3-dimethylaminopyrrolidine: a long-acting histamine antagonist.

R. Merriman, A. E. Ahmed, P. E. Hanna, 1973, Journal of Pharmacy and Science.

CONFORMATIONALLY RESTRICTED ANALOGS OF HISTAMIN H1 RECEPTOR ANTAGONISTS, TRANS- AND CIS-1,5-DIPHENYL-3-DIMETHYLAMINOPYRROLIDINE

A. E. Ahmed, P. E. Hanna, 1973 .

Flower Pollen Extract and its Effect on Cancer Cyclic Hydroxamic Acid Inhibitors of Prostate Cancer Cell Growth : Selectivity and Structure Activity relationships

K. Roberts, R. Iyer, P. E. Hanna, 2017 .

Chemical Modification of Hamster Arylamine N-Acetyltransferase 2 with Isozyme-Selective and Nonselective N-Arylbromoacetamido Reagents

C. Wagner, Haiqing Wang, Zhijun Guo, 2004, The protein journal.

Arylamine N-Acetyltransferases: Covalent Modification and Inactivation of Hamster NAT1 by Bromoacetamido Derivatives of Aniline and 2-Aminofluorene

C. Wagner, Zhijun Guo, G. M. Vath, 2003, Journal of Protein Chemistry.

Arylamine N-acetyltransferases. Expression in Escherichia coli, purification, and substrate specificities of recombinant hamster monomorphic and polymorphic isozymes.

C. Wagner, P. E. Hanna, C. Bergstrom, 1996, Drug Metabolism And Disposition.

Bioactivation of N-hydroxy-2-acetylaminofluorenes by N,O-acyltransferase: substituent effects on covalent binding to DNA.

P. E. Hanna, L. Boteju, 1993, Carcinogenesis.