A. Aubry

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Theory-guided efficient strategy to maximize speed and resolution in rapid gradient LC-MS/MS bioanalysis.

M. Jemal, M. Arnold, Jian Wang, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simple and efficient digestion of a monoclonal antibody in serum using pellet digestion: comparison with traditional digestion methods in LC-MS/MS bioanalysis.

Long Yuan, Mark E Arnold, Anne-Françoise Aubry, 2012, Bioanalysis.

Liquid chromatography mass spectrometry quantitative bioanalysis of proteins

A. Bergeron, Jean-Nicholas Mess, F. Garofolo, 2015 .

Post-pellet-digestion precipitation and solid phase extraction: A practical and efficient workflow to extract surrogate peptides for ultra-high performance liquid chromatography--tandem mass spectrometry bioanalysis of a therapeutic antibody in the low ng/mL range.

Naiyu Zheng, M. Arnold, A. Aubry, 2015, Journal of chromatography. A.

Feasibility assessment of a novel selective peptide derivatization strategy for sensitivity enhancement for the liquid chromatography/tandem mass spectrometry bioanalysis of protein therapeutics in serum.

Long Yuan, M. Arnold, A. Aubry, 2014, Rapid communications in mass spectrometry : RCM.

Systematic investigation of orthogonal SPE sample preparation for the LC-MS/MS bioanalysis of a monoclonal antibody after pellet digestion.

Long Yuan, M. Arnold, A. Aubry, 2013, Bioanalysis.

Development of a melanin-based high-performance liquid chromatography stationary phase and its use in the study of drug-melanin binding interactions.

A. Aubry, H. Ibrahim, 1995, Analytical biochemistry.

Chromatographic modelling of interactions between melanin and phenothiazine and dibenzazepine drugs.

R. Kaliszan, A. Aubry, H. Ibrahim, 1995, Biomedical chromatography : BMC.

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.

Hao Jiang, Jian Wang, Jianing Zeng, 2012, Analytical chemistry.

Best Practices in Biological Sample Preparation for LC‐MS Bioanalysis

Guowen Liu, A. Aubry, 2013 .

Development of Stability Indicating Methods

Peter I. Tattersall, A. Aubry, J. Ruan, 2009 .

Bioanalysis of propylparaben and p-hydroxybenzoic acid, and their sulfate conjugates in rat plasma by liquid chromatography-tandem mass spectrometry.

Jim X. Shen, L. Sivaraman, M. Arnold, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

LC-MS/MS determination of apixaban (BMS-562247) and its major metabolite in human plasma: an application of polarity switching and monolithic HPLC column.

Jim X. Shen, A. Schuster, Oanh T Dang, 2014, Bioanalysis.

A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma.

Hao Jiang, Jianing Zeng, Yuan-Qing Xia, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A simple, effective approach for rapid development of high-throughput and reliable LC-MS/MS bioanalytical assays.

Long Yuan, A. Aubry, Q. Ji, 2016, Bioanalysis.

A highly sensitive and selective LC-MS/MS method to quantify asunaprevir, an HCV NS3 protease inhibitor, in human plasma in support of pharmacokinetic studies.

Hao Jiang, T. Garimella, T. Eley, 2016, Journal of Pharmaceutical and Biomedical Analysis.

A UHPLC-MS/MS bioanalytical assay for the determination of BMS-911543, a JAK2 inhibitor, in human plasma.

Jim X. Shen, Jane Liu, Long Yuan, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.

Hao Jiang, T. Eley, B. He, 2015, Journal of pharmaceutical and biomedical analysis.

Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay.

Yuan-qing Xia, Long Yuan, Duxi Zhang, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A validated LC-MS/MS method for the simultaneous determination of BMS-791325, a hepatitis C virus NS5B RNA polymerase inhibitor, and its metabolite in plasma.

Hao Jiang, Z. Ouyang, Yuan-qing Xia, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.

Bonnie Wang, M. Arnold, Jian Wang, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Hao Jiang, Jianing Zeng, Mark E Arnold, 2013, Analytical chemistry.

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

R. Dodge, A. Allentoff, Hao Jiang, 2014, Analytical Chemistry.

Application of a stabilizer cocktail of N-ethylmaleimide and phenylmethanesulfonyl fluoride to concurrently stabilize the disulfide and ester containing compounds in a plasma LC-MS/MS assay.

Wenying Jian, Long Yuan, Duxi Zhang, 2014, Journal of pharmaceutical and biomedical analysis.

Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples

A. Allentoff, A. Aubry, Q. Ji, 2015, The AAPS Journal.

Systematic evaluation of the root cause of non-linearity in liquid chromatography/tandem mass spectrometry bioanalytical assays and strategy to predict and extend the linear standard curve range.

M. Jemal, Long Yuan, Duxi Zhang, 2012, Rapid communications in mass spectrometry : RCM.

Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma.

T. Olah, Yuan-qing Xia, M. Jemal, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.

T. Olah, Yan Zhang, H. Vezina, 2016, Bioanalysis.

An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.

Robert J. Neely, S. Piccoli, H. Vezina, 2015, Bioanalysis.

Selective reaction monitoring of negative electrospray ionization acetate adduct ions for the bioanalysis of dapagliflozin in clinical studies.

Jim X. Shen, D. Boulton, Jane Liu, 2015, Analytical chemistry.

Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma.

M. Tirmenstein, J. Cai, Yuzhong Deng, 2010, Bioanalysis.

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

Surinder Kaur, Jianing Zeng, Faye Vazvaei, 2014, The AAPS Journal.

Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics.

Yan J. Zhang, A. Allentoff, Naiyu Zheng, 2016, Analytica chimica acta.

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

P. Shipkova, A. Tymiak, A. Minnich, 2014, Journal of Lipid Research.

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity

Naidong Weng, U. Diczfalusy, B. Dean, 2016, The AAPS Journal.

UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions.

F. LaCreta, Naiyu Zheng, Xuewen Ma, 2016, Bioanalysis.

Improved ruggedness of an ion-pairing liquid chromatography/tandem mass spectrometry assay for the quantitative analysis of the triphosphate metabolite of a nucleoside reverse transcriptase inhibitor in peripheral blood mononuclear cells.

Jim X. Shen, M. Guha, Long Yuan, 2013, Rapid communications in mass spectrometry : RCM.

A sensitive method for the determination of entecavir at picogram per milliliter level in human plasma by solid phase extraction and high-pH LC-MS/MS.

J. Gale, Duxi Zhang, Yunlin Fu, 2009, Journal of pharmaceutical and biomedical analysis.

Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays.

Hao Jiang, R. Dodge, Craig Titsch, 2015, Journal of immunological methods.

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

Hao Jiang, Jianing Zeng, Mark E Arnold, 2012, Analytical chemistry.

Chiral purity assay for Flindokalner using tandem mass spectrometry: method development, validation, and benchmarking.

R. Cooks, Scott A. Miller, Jingpin Jia, 2007, Journal of pharmaceutical and biomedical analysis.

Column selection and method development for the determination of the enantiomeric purity of investigational non-nucleoside reverse transcriptase inhibitors.

R. C. Williams, R. Boucher, A. Aubry, 2001, Chirality.

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics

Yan J. Zhang, Jean W. Lee, F. Garofolo, 2014, The AAPS Journal.

Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection.

Naiyu Zheng, M. Arnold, A. Aubry, 2016, Analytica chimica acta.

Separation and identification of dipeptides in a hydrolyzed brain extract

R. Rosset, M. Caude, A. Aubry, 1992 .

Selectivity in capillary electrophoresis: the use of proteins.

E. De Lorenzi, D. Lloyd, A. Aubry, 1997, Journal of chromatography. A.

Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis.

Jian Wang, Mohammed Jemal, Huidong Gu, 2010, Rapid communications in mass spectrometry : RCM.

The direct determination of the enantiomers of ketorolac and parahydroxyketorolac in plasma and urine using enantioselective liquid chromatography on a human serum albumin-based chiral stationary phase

I. Wainer, A. Aubry, John C. Chen, 1994 .

Chiral analysis of drug substance in clinical plasma extracts using achiral HPLC with circular dichroism detection.

R. C. Williams, A. Aubry, J. F. Edwards, 2001, Journal of pharmaceutical and biomedical analysis.

Applications of affinity chromatography to the study of drug-melanin binding interactions.

A. Aubry, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The effects of pH and alcoholic organic modifiers on the direct separation of some acidic, basic and neutral compounds on a commercially available ovomucoid column

I. Wainer, A. Aubry, J. Iredale, 1991 .

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity

Naidong Weng, U. Diczfalusy, B. Dean, 2016, The AAPS Journal.

Selecting the correct weighting factors for linear and quadratic calibration curves with least-squares regression algorithm in bioanalytical LC-MS/MS assays and impacts of using incorrect weighting factors on curve stability, data quality, and assay performance.

Huidong Gu, Mark E. Arnold, Guowen Liu, 2014, Analytical chemistry.

Application of a design of experiment approach in the development of a sensitive bioanalytical assay in human plasma.

A. Schuster, A. Aubry, J. Bergum, 2012, Journal of pharmaceutical and biomedical analysis.

Impurity profiling of non-nucleoside reverse transcriptase inhibitors by HPLC using a porous graphitic carbon stationary phase

A. Aubry, J. Q. Xu, 2003 .

Automated dried blood spots standard and QC sample preparation using a robotic liquid handler.

Long Yuan, Mark E Arnold, Duxi Zhang, 2012, Bioanalysis.

The Effect of Co‐administered Drugs on Oxaprozin Binding to Human Serum Albumin

J. Longstreth, I. Wainer, N. Markoglou, 1995, The Journal of pharmacy and pharmacology.

Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

Naiyu Zheng, Jianing Zeng, Mark E Arnold, 2014, Journal of pharmaceutical and biomedical analysis.

Dried blood spot analysis without dilution: Application to the LC-MS/MS determination of BMS-986001 in rat dried blood spot.

Jim X. Shen, A. Schuster, Long Yuan, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

LC-MS/MS bioanalytical challenge: ultra-high sensitivity assays.

Anne-Françoise Aubry, A. Aubry, 2011, Bioanalysis.

Evaluation of a chiral stationary phase based on mixed immobilized proteins

I. Wainer, N. Markoglou, A. Aubry, 1994 .

BIS repetita non placent -- a statistical analysis of the number of sample preparations and number of injections required for chromatographic analyses.

C. Riley, A. Aubry, Rob Noble, 2005, Journal of pharmaceutical and biomedical analysis.

High-resolution MS in regulated bioanalysis: where are we now and where do we go from here?

M. Jemal, A. Aubry, E. Fung, 2013, Bioanalysis.

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

Naiyu Zheng, Jianing Zeng, Yuan-Qing Xia, 2013, Journal of pharmaceutical and biomedical analysis.

Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach

Hao Jiang, Craig Titsch, Barry Jones, 2017, Journal of pharmaceutical and biomedical analysis.

Enantioselective chromatography of the antimalarial agents chloroquine, mefloquine, and enpiroline on a α1-acid glycoprotein chiral stationary phase : evidence for a multiple-site chiral recognition mechanism

R. Farinotti, I. Wainer, A. Aubry, 1992 .

Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients

J. Bras, I. Wainer, O. Bouchaud, 2004, European Journal of Clinical Pharmacology.

Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples

A. Allentoff, A. Aubry, Q. Ji, 2015, The AAPS Journal.

"Center punch" and "whole spot" bioanalysis of apixaban in human dried blood spot samples by UHPLC-MS/MS.

Naiyu Zheng, Jianing Zeng, Yan Song, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Reflecting on a decade of metabolite screening and monitoring.

Jian Wang, Mark E Arnold, Anne-Françoise Aubry, 2014, Bioanalysis.

A validated enantioselective LC-MS/MS assay for quantification of a major chiral metabolite of an achiral 11-β-hydroxysteroid-dehydrogenase 1 inhibitor in human plasma: Application to a clinical pharmacokinetic study.

John W. Bruce, L. Iacono, M. Furlong, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.

A. Kozhich, F. Zambito, H. Myler, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions.

Jian Wang, Mark E Arnold, Anne-Françoise Aubry, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.

A. Kozhich, F. Zambito, H. Myler, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 2 - hybrid LBA/LCMS, ELN & regulatory agencies' input).

Lindsay King, Stacy Ho, Roger Hayes, 2014, Bioanalysis.

Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma.

T. Olah, Yuan-qing Xia, M. Jemal, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Naiyu Zheng, M. Arnold, A. Aubry, 2015, Journal of chromatography. A.

Effect of a high‐fat meal on the pharmacokinetics of dapagliflozin, a selective SGLT2 inhibitor, in healthy subjects

F. LaCreta, D. Boulton, M. Pfister, 2011, Diabetes, obesity & metabolism.

Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development.

R. Dodge, A. Allentoff, Hao Jiang, 2014, Analytical chemistry.

Bioanalysis and where does it fit into the drug development process

Anne-Françoise Aubry, Jim X Shen, Jim X. Shen, 2013 .