T. Khroyan

发表

Dose-dependent characterization of the rewarding and stimulant properties of cocaine following intraperitoneal and intravenous administration in rats

J. Neisewander, L. O’Dell, T. Khroyan, 2005, Psychopharmacology.

Pharmacology of mixed NOP/mu ligands

S. Husbands, N. Zaveri, L. Toll, 2013 .

Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.

S. Husbands, L. Toll, W. Polgar, 2011, Journal of medicinal chemistry.

Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Agonists

N. Zaveri, L. Toll, W. Polgar, 2009, Journal of Pharmacology and Experimental Therapeutics.

Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists.

J. Orduña, N. Zaveri, L. Toll, 2009, European journal of pharmacology.

Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/μ-Opioid Receptor Ligands: Implications for Therapeutic Applications

N. Zaveri, L. Toll, W. Polgar, 2009, Journal of Pharmacology and Experimental Therapeutics.

Activities of mixed NOP and μ‐opioid receptor ligands

G. Calo’, S. Husbands, J. Lewis, 2008, British journal of pharmacology.

AT‐1001: a high‐affinity α3β4 nAChR ligand with novel nicotine‐suppressive pharmacology

R. Ciccocioppo, Xinmin Xie, Jennifer Schoch, 2015, British journal of pharmacology.

High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice.

N. Zaveri, L. Toll, W. Polgar, 2015, Biochemical pharmacology.

Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception

I. Lindberg, S. Eans, J. McLaughlin, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential Effects of Nociceptin/Orphanin FQ (NOP) Receptor Agonists in Acute versus Chronic Pain: Studies with Bifunctional NOP/μ Receptor Agonists in the Sciatic Nerve Ligation Chronic Pain Model in Mice

J. Orduña, N. Zaveri, L. Toll, 2011, Journal of Pharmacology and Experimental Therapeutics.

Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.

A. Yamanaka, T. Horvath, T. Sakurai, 2008, The Journal of clinical investigation.

Rodent Behavioral Assessment in the Home Cage Using the SmartCage™ System

B. Zou, Xinmin Xie, Jidong Fang, 2012 .

BU 08073 a Buprenorphine Analog with Partial Agonist Activity at mu Receptors in vitro but Long-Lasting Opioid Antagonist Activity in vivo in Mice 1

S. Husbands, N. Fotaki, L. Toll, 2014 .

The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward

S. Husbands, N. Zaveri, L. Toll, 2011, Journal of Pharmacology and Experimental Therapeutics.

The First Universal Opioid Ligand , ( 2 S )-2-[ ( 5 R , 6 R , 7 R

S. Husbands, N. Zaveri, L. Toll, 2011 .

The First ‘Universal Opioid Ligand’ Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-induced Reward.

S. Husbands, N. Zaveri, W. Polgar, 2010 .

Synthesis and biological evaluation of some 6-arylamidomorphines as analogues of morphine-6-glucuronide.

Xiaodong Zhang, J. Macdougall, J. Cashman, 2004, Bioorganic & medicinal chemistry.

N-terminal modifications leading to peptide ORL1 partial agonists and antagonists.

D. Tuttle, L. Toll, W. Polgar, 2003, The journal of peptide research : official journal of the American Peptide Society.

Rodent models of nicotine reward: What do they tell us about tobacco abuse in humans?

L. O’Dell, T. Khroyan, 2009, Pharmacology Biochemistry and Behavior.

Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide.

Xiaodong Zhang, J. Macdougall, J. Cashman, 2005, Bioorganic & medicinal chemistry letters.

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

Mark P Thomas, S. Husbands, L. Toll, 2018, Front. Psychiatry.

Differential Effects of NOP Receptor Agonists in Acute versus Chronic Pain: Studies with Bifunctional NOP/mu Receptor Agonists in the Sciatic Nerve Ligation Chronic Pain Model in Mice

J. Orduña, N. Zaveri, L. Toll, 2011 .

Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents.

D. Tuttle, J. Orduña, L. Toll, 2007, European journal of pharmacology.

SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice

J. Orduña, N. Zaveri, L. Toll, 2007, Journal of Pharmacology and Experimental Therapeutics.

Genetics of nicotine dependence and pharmacotherapy.

Christina N. Lessov-Schlaggar, C. N. Lessov-Schlaggar, G. Swan, 2008, Biochemical pharmacology.

Genetics and Drug Use as a Complex Phenotype

Caryn Lerman, Taline V Khroyan, G. Swan, 2004, Substance use & misuse.

Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation.

H. Feiler, J. Illes, D. Carmelli, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation.

Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCage™

Adam Malik, Lawrence Toll, Liya Yang, 2012, Clinical and experimental pharmacology & physiology.

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.

H. Heller, D. Colas, O. Boutaud, 2016, Brain : a journal of neurology.

Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide.

Xiaodong Zhang, J. Macdougall, J. Cashman, 2004, Journal of medicinal chemistry.

Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity.

N. Zaveri, L. Toll, G. Stauber, 2013, European journal of pharmacology.

In Vitro and In Vivo Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential

J. Lawson, L. Toll, A. Cippitelli, 2017, Front. Psychiatry.

Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior

R. Spealman, T. Khroyan, R. D Spealman, 1999, Pharmacology Biochemistry and Behavior.

Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective.

S. Santangelo, M. Lyons, G. Swan, 2003, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

BU08073 a buprenorphine analogue with partial agonist activity at μ‐receptors in vitro but long‐lasting opioid antagonist activity in vivo in mice

S. Husbands, N. Fotaki, L. Toll, 2015, British journal of pharmacology.

Effects of 7-OH-DPAT on cocaine-seeking behavior and on re-establishment of cocaine self-administration

R. A. Fuchs, S. Weber, J. Neisewander, 2002, Pharmacology Biochemistry and Behavior.

Behavioral interactions produced by co-administration of 7-OH-DPAT with cocaine or apomorphine in the rat

R. A. Fuchs, J. Neisewander, T. Khroyan, 1999, Psychopharmacology.

Effects of intraaccumbens administration of SCH‐23390 on cocaine‐induced locomotion and conditioned place preference

R. A. Fuchs, D. Baker, J. Neisewander, 1998, Synapse.

Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.

R. Spealman, T. Khroyan, J. Rowlett, 2000, The Journal of pharmacology and experimental therapeutics.

Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates

R. Spealman, T. Khroyan, J. Rowlett, 2003, Psychopharmacology.

Dopamine D 1-and D 2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior : Effects of Selective Antagonists and Agonists 1

R. Spealman, T. Khroyan, J. Rowlett, 2000 .

Varenicline enhances dopamine release facilitation more than nicotine after long-term nicotine treatment and withdrawal

M. Quik, J. McIntosh, X. Perez, 2014, Pharmacology research & perspectives.

Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.

N. Zaveri, W. Polgar, V. B. Journigan, 2014, Bioorganic & medicinal chemistry.

Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR

G. Swan, L. Jack, T. Mcafee, 2005, The Pharmacogenomics Journal.

Effects of SCH‐23390 on dopamine D1 receptor occupancy and locomotion produced by intraaccumbens cocaine infusion

R. A. Fuchs, J. Neisewander, L. O’Dell, 1998, Synapse.

Differential effects of 7-OH-DPAT on amphetamine-induced stereotypy and conditioned place preference

R. A. Fuchs, D. Baker, J. Neisewander, 1998, Psychopharmacology.

Triggers of relapse: nonhuman primate models of reinstated cocaine seeking.

R. Spealman, T. Khroyan, S. Tiefenbacher, 2004, Nebraska Symposium on Motivation. Nebraska Symposium on Motivation.