Wenying Li

发表

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement

W. Humphreys, L. Hamann, Y. Shu, 2016, Drug Metabolism and Disposition.

Accelerated Communication GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT , METABOLISM-DEPENDENT INHIBITOR OF CYP 2 C 8 : IMPLICATIONS FOR DRUG-DRUG INTERACTIONS

A. D. Rodrigues, A. Parkinson, Donglu Zhang, 2005 .

Metabolite Generation via Microbial Biotransformations with Actinomycetes: Rapid Screening for Active Strains and Biosynthesis of Important Human Metabolites of Two Development-Stage Compounds, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methy

W. Humphreys, G. Skiles, J. Josephs, 2008, Drug Metabolism and Disposition.

Pharmacokinetics of the NS3 Protease Inhibitor, Asunaprevir (ASV, BMS‐650032), in Phase I Studies in Subjects With or Without Chronic Hepatitis C

A. D. Rodrigues, R. Bertz, D. Grasela, 2013, Clinical pharmacology in drug development.

Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Martin C. Wright, J. Bryson, V. Lafont, 2018, Protein engineering, design & selection : PEDS.

Daclatasvir: A Review of Preclinical and Clinical Pharmacokinetics

A. Fura, T. Garimella, R. Bertz, 2018, Clinical Pharmacokinetics.

Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans

Hao Jiang, W. Humphreys, V. Arora, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment

W. Humphreys, Donglu Zhang, R. Ramanathan, 2011, Drug Metabolism and Disposition.

Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro

A. D. Rodrigues, Hongjiang Zhang, B. Wen, 2008, Drug Metabolism and Disposition.

BIOTRANSFORMATION OF CARBON-14-LABELED MURAGLITAZAR IN MALE MICE: INTERSPECIES DIFFERENCE IN METABOLIC PATHWAYS LEADING TO UNIQUE METABOLITES

W. Humphreys, Donglu Zhang, Lifei Wang, 2006, Drug Metabolism and Disposition.

Organic reactions in frozen water: Michael addition of amines and thiols to the dehydroalanine side chain of nocathiacins

K. S. Lam, T. Connolly, J. Bronson, 2004 .

Reduction of Site-Specific CYP3A-Mediated Metabolism for Dual Angiotensin and Endothelin Receptor Antagonists in Various in Vitro Systems and in Cynomolgus Monkeys

W. Humphreys, N. Murugesan, Z. Gu, 2007, Drug Metabolism and Disposition.

Asunaprevir: An HCV Protease Inhibitor With Preferential Liver Distribution

T. Garimella, R. Bertz, T. Eley, 2017, Clinical pharmacology in drug development.

Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. I. Taxonomy, fermentation and biological activities.

J. Leet, K. S. Lam, Daniel M. Brown, 2003, The Journal of antibiotics.

Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.

Stella Huang, Joseph L. Cantone, D. Drexler, 2003, The Journal of antibiotics.

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).

S. Sheriff, R. Seethala, A. Nayeem, 2011, Bioorganic & medicinal chemistry letters.

In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2′-C-Methylguanosine Prodrug BMS-986094

W. Humphreys, O. Flint, M. Davies, 2017, International journal of toxicology.

Synthesis and antibacterial activity of nocathiacin I analogues.

K. S. Lam, M. Pucci, T. Connolly, 2006, Bioorganic & medicinal chemistry letters.

Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics.

K. S. Lam, M. Pucci, T. Connolly, 2004, Bioorganic & medicinal chemistry letters.

N-Demethylation of nocathiacin I via photo-oxidation.

Stella Huang, Joseph L. Cantone, J. Leet, 2008, Bioorganic & Medicinal Chemistry Letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.

L. Hamann, N. Meanwell, Tao Wang, 2016, Bioorganic & medicinal chemistry letters.

Fluoride-catalyzed intramolecular denitrocyclization of nitrotoluenes to indanes

J. Thottathil, Wenying Li, 1994 .

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.

P. Lam, W. Humphreys, A. Mathur, 2015, The Journal of organic chemistry.

Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin.

Y. Shu, K. S. Lam, S. Gerritz, 2005, Bioorganic & medicinal chemistry letters.

Asunaprevir: A Review of Preclinical and Clinical Pharmacokinetics and Drug–Drug Interactions

T. Garimella, R. Bertz, T. Eley, 2015, Clinical Pharmacokinetics.

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

A. D. Rodrigues, Jinping Gan, Yuan Tian, 2010, British journal of clinical pharmacology.

Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics

W. Humphreys, Donglu Zhang, R. Iyer, 2008, Drug Metabolism and Disposition.

Biotransformation of [14C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys

W. Humphreys, V. Arora, K. He, 2008, Drug Metabolism and Disposition.

Biotransformation of [14C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys

W. Humphreys, V. Arora, K. He, 2008, Drug Metabolism and Disposition.

GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS

A. D. Rodrigues, A. Parkinson, Donglu Zhang, 2006, Drug Metabolism and Disposition.

Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling

W. Humphreys, Haiying Zhang, Litao Zhang, 2007, Drug Metabolism and Disposition.

Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp. Part 1. Taxonomy, Fermentation and Biological Activities.

Wenying Li, 2003 .

Purification, cloning, and functional expression of phenylalanine aminomutase: the first committed step in Taxol side-chain biosynthesis.

B. Dougherty, K. S. Lam, S. Chiang, 2005, Archives of biochemistry and biophysics.

Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".

P. Lam, W. Humphreys, A. Mathur, 2015, Journal of Organic Chemistry.

Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs

W. Humphreys, Li Ma, Shu-Ying Chang, 2016, Drug Metabolism and Disposition.

Absolute and Relative Bioavailability of Oral Solid Dosage Formulations of Deucravacitinib in Humans.

B. He, Jonathan Brown, Wenying Li, 2023, Clinical pharmacology in drug development.

In Vitro Characterization and Pharmacokinetics of Dapagliflozin (BMS-512148), a Potent Sodium-Glucose Cotransporter Type II Inhibitor, in Animals and Humans

W. Humphreys, B. Koplowitz, A. Khanna, 2010, Drug Metabolism and Disposition.

Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro

Hongjiang Zhang, B. Wen, Shu-Ying Chang, 2008, Drug Metabolism and Disposition.

Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1

W. Humphreys, Hong Shen, Wenying Li, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment

W. Humphreys, Donglu Zhang, R. Ramanathan, 2011, Drug Metabolism and Disposition.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics

Donglu Zhang, R. Iyer, Lifei Wang, 2008, Drug Metabolism and Disposition.