J. Easter

发表

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement

W. Humphreys, L. Hamann, Y. Shu, 2016, Drug Metabolism and Disposition.

Synthesis of carbon‐14 labelled midazolam

S. Bonacorsi, J. Easter, Balu N Balasubramanian, 2009 .

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.

Hao Jiang, Jian Wang, Jianing Zeng, 2012, Analytical chemistry.

Synthesis of isotopically labeled daclatasvir for use in human clinical studies.

S. Bonacorsi, J. Easter, R. Burrell, 2016, Journal of labelled compounds & radiopharmaceuticals.

Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.

Hao Jiang, T. Eley, B. He, 2015, Journal of pharmaceutical and biomedical analysis.

LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions.

Yan J. Zhang, Rasa Santockyte, J. Gan, 2018, Bioanalysis.

Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans

Hao Jiang, W. Humphreys, V. Arora, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

P. Shipkova, A. Tymiak, A. Minnich, 2014, Journal of Lipid Research.

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

Hao Jiang, Jianing Zeng, Mark E Arnold, 2012, Analytical chemistry.

An asymmetric synthesis of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo-[4,5,1-ij]quinolin-2(1H)-one (1) and its [2-14C]- and [6,7-3H2]-labeled forms

J. Easter, R. F. Heier, R. Hsi, 1996 .

Stereochemical effects in the nitrosation of some α,β‐unsaturated ketoximes. Formation of 1‐hydroxypyrazole 2‐oxides and 4‐oximino‐4,5‐dihydroisoxazoles

J. Easter, J. F. Hansen, J. Hansen, 1994 .

Preparation of 4‐bromo‐1‐hydroxypyrazole 2‐oxides by nitrosation of α‐bromo‐α,β‐unsaturated ketoximes

J. Easter, J. F. Hansen, D. A. Little, 1994 .

An alternative and robust synthesis of [(13) C4 ]Baraclude® (entecavir).

S. Bonacorsi, J. Easter, R. Burrell, 2013, Journal of labelled compounds & radiopharmaceuticals.

Stereoselective synthesis of [11 β‐3H]prostaglandin E1

G. Bundy, J. Easter, R. Hsi, 1993 .

Synthesis of [14C] ‐ and [13C6]‐labeled tipranavir and its potential hydroxyl metabolite and the glucuronide conjugate

C. Senanayake, B. Latli, D. Krishnamurthy, 2008 .

UHPLC-MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions.

Kumar A. Shah, Yan J. Zhang, Rasa Santockyte, 2018, Bioanalysis.

Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease.

R. Olson, M. Cassidy, S. Bonacorsi, 2014, Journal of labelled compounds & radiopharmaceuticals.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

Assessment of radioactive residues arising from radiolabel instability in a multiple dose tissue distribution study in rats.

Mark Johnson, J. Sams, G. Fate, 2003, Biological & pharmaceutical bulletin.

Synthesis of isotopically labeled CIS‐(3aR)‐(‐)‐2,3,3a,4,5,9b‐hexahydro‐3‐(N‐propyl)‐1H‐benz[e]indole‐9‐carboxamide, a 5‐HT1A receptor agonist

M. Ackland, S. Haadsma-Svensson, J. Easter, 1997 .

Synthesis of Tritium Labeled 30 KDa PEG and Conjugation to form [3 H]Pegbelfermin.

S. Bonacorsi, J. Easter, R. Burrell, 2021, Journal of labelled compounds & radiopharmaceuticals.