M. Leivers

发表

Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.

C. Moore, A. Mathis, J. Botyánszki, 2014, Journal of medicinal chemistry.

A Randomized, Double‐Blind, Placebo‐Controlled, First‐Time‐in‐Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects

R. Elston, J. Ritter, R. Hamatake, 2019, Clinical pharmacology in drug development.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Randomized clinical trials towards a single‐visit cure for chronic hepatitis C: Oral GSK2878175 and injectable RG‐101 in chronic hepatitis C patients and long‐acting injectable GSK2878175 in healthy participants

R. Hamatake, B. Jilma, I. Goulis, 2020, Journal of viral hepatitis.

Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism.

Ryan Lauchli, A. Mathis, John F. Miller, 2014, Journal of medicinal chemistry.

Concerning two-metal cooperativity in model phosphate hydrolysis.

R. Breslow, M. Leivers, 2001, Bioorganic chemistry.

Synthesis of HCV replicase inhibitors: base-catalyzed synthesis of protected α-hydrazino esters and selective aerobic oxidation with catalytic Pt/Bi/C for synthesis of imidazole-4,5-dicarbaldehyde.

D. E. Patterson, John F. Miller, M. Mitchell, 2013, The Journal of organic chemistry.

A forbidden rearrangement.

R. Breslow, Iris W. Tam, D. Leung, 2003, Organic letters.

GSK2818713, a novel biphenylene scaffold-based Hepatitis C NS5A replication complex inhibitor with broad genotype coverage.

R. Hamatake, W. Kazmierski, R. Crosby, 2020, Journal of medicinal chemistry.

GSK2878175, a pan‐genotypic non‐nucleoside NS5B polymerase inhibitor, in healthy and treatment‐naïve chronic hepatitis C subjects

R. Hamatake, Z. Hong, E. Dumont, 2018, Journal of viral hepatitis.

P1224 GSK2878175, A POTENT NON-NUCLEOSIDE INHIBITOR OF HCV NS5B WITH PAN-GENOTYPIC ACTIVITY

R. Hamatake, Z. Hong, R. Crosby, 2014 .

Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound.

R. Hamatake, W. Kazmierski, R. Crosby, 2014, Journal of medicinal chemistry.