J. Kuethe

发表

Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172.

G. Beutner, G. Humphrey, S. Dreher, 2013, Organic letters.

Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.

Paul N. Devine, D. Tellers, D. Zewge, 2011, The Journal of organic chemistry.

Magnetically driven agitation in a tube mixer affords clog-resistant fast mixing independent of linear velocity.

Jeffrey T. Kuethe, Jeffrey T Kuethe, S. Dolman, 2011, The Journal of organic chemistry.

A concise synthesis of 3,4-fused spiro[isobenzofuran-3-ones], spiro[furo[3,4-b]pyridin-5(7H)-ones], 3-aryl-, and alkylphthalides

Jeffrey T. Kuethe, K. Maloney, J. Kuethe, 2013 .

Synthesis of stable isotope labeled anacetrapib, its major metabolites and [(14) C]anacetrapib.

C. A. Quinn, J. Kuethe, Eric D Soli, 2013, Journal of labelled compounds & radiopharmaceuticals.

Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors

Jeremy P. Scott, D. Tellers, I. Davies, 2009 .

Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex

Daniel J. Muzzio, Jeffrey T. Kuethe, F. Fleitz, 2012 .

The tandem Pummerer-isomünchnone route to (±)-pumiliotoxin C

A. Padwa, J. Kuethe, 1997 .

Using the Pummerer cyclization-deprotonation-cycloaddition cascade of imidosulfoxides for alkaloid synthesis.

Jeffrey T. Kuethe, A. Padwa, J. Kuethe, 2000, The Journal of organic chemistry.

Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters

Jeffrey T. Kuethe, Yu-hong Lam, A. Buevich, 2022, Molecules.

Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.

Youwei Yan, Ping Chen, J. Metzger, 2015, Bioorganic & medicinal chemistry letters.

A rapid synthesis of 2-aryl-5-substituted-2,3-dihydrobenzofurans.

Jeffrey T. Kuethe, I. Davies, M. Journet, 2005, The Journal of organic chemistry.

A Rapid, Large-Scale Synthesis of a Potent Cholecystokinin (CCK) 1R Receptor Agonist

Jeffrey T. Kuethe, G. Humphrey, M. Journet, 2008 .

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2013, ACS medicinal chemistry letters.

A concise synthesis of functionalized 2,3-dihydrofuro[3,2-b], [3,2-c], and [2,3-b]pyridines

J. Kuethe, 2019, Tetrahedron.

Expedient synthesis of 3-alkoxymethyl- and 3-aminomethyl-pyrazolo[3,4-b]pyridines.

G. Beutner, N. Yasuda, J. Kuethe, 2009, The Journal of organic chemistry.

Practical methodologies for the synthesis of indoles.

Jeffrey T. Kuethe, G. Humphrey, J. Kuethe, 2006, Chemical reviews.

Synthesis of 5-substituted-1H-indol-2-yl-1H-quinolin-2-ones: a novel class of KDR kinase inhibitors.

I. Davies, D. Hughes, J. Kuethe, 2005, The Journal of organic chemistry.

One-pot iodination of hydroxypyridines.

Jeffrey T. Kuethe, K. Maloney, Jingjun Yin, 2009, The Journal of organic chemistry.

A practical, one-pot synthesis of sulfonylated pyridines.

K. Maloney, J. Kuethe, Katherine Linn, 2011, Organic letters.

Suzuki–Miyaura Cross-Coupling of 2-Nitroarenediazonium Tetrafluoroborates: Synthesis of Unsymmetrical 2-Nitrobiphenyls and Highly Functionalized Carbazoles

Jeffrey T. Kuethe, J. Kuethe, K. Childers, 2008 .

Addition of indolyl and pyrrolyl grignard reagents to 1-acylpyridinium salts.

D. Comins, J. Kuethe, 2004, The Journal of organic chemistry.

Preparation of 2-arylindole-4-carboxylic amide derivatives

Jeffrey T. Kuethe, I. Davies, J. Kuethe, 2006 .

A Concise Synthesis of (S)-N-Ethoxycarbonyl-α-methylvaline

G. Beutner, D. Gauthier, N. Yasuda, 2007 .

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

M. Truppo, J. Janey, J. Arredondo, 2014 .

Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles.

Scott R Pollack, J. Kuethe, 2016, Organic letters.

Diels-Alder reactions of N-acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones.

D. Comins, J. Kuethe, C. Brooks, 2005, The Journal of organic chemistry.

Rearrangement of spiro-benzimidazolines : preparation of N-alkenyl-and N-alkyl-benzimidazol-2-ones

J. Kuethe, K. Childers, Jack Varon, 2007 .

Synthesis of novel KDR kinase inhibitors through catalytic reductive cyclization of o-nitrobenzylcarbonyl compounds.

I. Davies, D. Hughes, J. Kuethe, 2004, The Journal of organic chemistry.

DIASTEREOSELECTIVE ADDITION OF PROCHIRAL METALLO ENOLATES TO CHIRAL 1-ACYLPYRIDINIUM SALTS

A. Rheingold, D. Comins, F. Lakner, 1999 .

Synthesis of disubstituted imidazo[4,5-b]pyridin-2-ones.

I. Davies, J. Kuethe, Audrey Wong, 2004, The Journal of organic chemistry.

Synthesis of 2‐Arylindole‐4‐Carboxylic Amides: [2‐(4‐Fluorophenyl)‐1H‐Indol‐4‐YL]‐1‐Pyrrolidinylmethanone

G. Beutner, J. Kuethe, 2009 .

Aza-Diels–Alder/intramolecular Heck cyclization approach to the tetrahydro-β-carboline skeleton of the ajmaline/sarpagine alkaloids

I. Davies, P. Reider, J. Kuethe, 2002 .

The Reaction of α-Diazo-β-hydroxy Esters with Boron Trifluoride Etherate: Generation and Rearrangement of Destabilized Vinyl Cations. A Detailed Experimental and Theoretical Study

J. Snyder, A. Padwa, B. Natalini, 1996 .

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.

Shirly Pinto, M. Reibarkh, R. DeVita, 2019, Bioorganic & medicinal chemistry letters.

A Biocatalytic/Reductive Etherification Approach to Substituted Piperidinyl Ethers.

M. Truppo, J. Janey, J. Arredondo, 2014 .

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.

Shirly Pinto, J. Lisnock, R. DeVita, 2014, ACS medicinal chemistry letters.

Stereoselective preparation of a cyclopentane-based NK1 receptor antagonist bearing an unsymmetrically substituted sec-sec ether.

I. Davies, D. Hughes, P. Dormer, 2006, The Journal of organic chemistry.

Rapid and Efficient Synthesis of 1 H -Indol-2-yl-1 H -quinolin-2-ones

I. Davies, J. Kuethe, A. Wong, 2004 .

Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.

Jeffrey T. Kuethe, J. Demartino, E. Sherer, 2016, Journal of medicinal chemistry.

Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist

Dalian Zhao, G. Humphrey, M. Journet, 2016 .

New Application of the Pummerer Reaction of Imidosulfoxides for the Generation of Mesoionic Dipoles

A. Padwa, J. Kuethe, 1997 .

Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones.

Jeffrey T. Kuethe, I. Davies, J. Kuethe, 2003, Organic letters.

Effective strategy for the preparation of indolocarbazole aglycons and glycosides: total synthesis of tjipanazoles B, D, E, and I.

I. Davies, J. Kuethe, Audrey Wong, 2003, Organic letters.

A General Approach to Indoles: Practical Applications for the Synthesis of Highly Functionalized Pharmacophores

J. Kuethe, 2007 .

Formal [4+2] cycloaddition reactions of N-sulfonyl-2,2′-biindoles: synthesis of indolo[2,3-a]carbazoles and indigo azines

I. Davies, J. Kuethe, 2004 .

Effective strategy for the preparation of indolocarbazole aglycons and glycosides: total synthesis of tjipanazoles B, D, E, and I.

I. Davies, J. Kuethe, Audrey Wong, 2003, Organic letters.

Tandem Pummerer/Mannich cyclization cascade of alpha-sulfinylamides as a method to prepare aza-heterocycles.

A. Padwa, J. Kuethe, Qiu Wang, 2002, The Journal of organic chemistry.

A general approach to indoles : Practical applications for the synthesis of highly functionalized pharmacophores

J. Kuethe, 2006 .

A general synthesis of N-hydroxyindoles.

I. Davies, J. Kuethe, Audrey Wong, 2003, The Journal of organic chemistry.

Asymmetric total synthesis of (+)-cannabisativine.

D. Comins, J. Kuethe, 2004, The Journal of organic chemistry.

Asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes as key components of substance p antagonists.

C. Welch, I. Davies, P. Reider, 2002, The Journal of organic chemistry.

Cyclopentane‐Based NK1 Receptor Antagonist

J. Kuethe, 2010 .

Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

Jeffrey T. Kuethe, Justin A. Newman, T. Itoh, 2023, Green Chemistry.

Reactive resin facilitated preparation of an enantiopure fluorobicycloketone.

C. Welch, I. Davies, D. Hughes, 2004, Organic & biomolecular chemistry.

Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether.

L. Tan, M. Poirier, Eric Ashley, 2017, Bioorganic & medicinal chemistry.

Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor.

G. Humphrey, M. Journet, J. Kuethe, 2016, The Journal of organic chemistry.

Asymmetric bioreduction of α,β-unsaturated nitriles and ketones

Paul N. Devine, Jeffrey T. Kuethe, F. Fleitz, 2008 .

Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles.

R. Orr, Louis-Charles Campeau, M. Tudge, 2014, Organic letters.

Practical preparation of benzyloxyacetic acids

N. Yasuda, J. Kuethe, Katherine Linn, 2008 .

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

Kathy Lyons, Ping Chen, Dennis Feng, 2014, Journal of medicinal chemistry.

Asymmetric aza-Diels–Alder reactions of indole 2-carboxaldehydes

I. Davies, D. Mathre, P. Reider, 2002 .

A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines

Jeffrey T. Kuethe, G. Beutner, N. Yasuda, 2009 .

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

John D. Schreier, Min Xu, D. Hazuda, 2015, Journal of medicinal chemistry.

A practical method for preparation of 4-hydroxyquinolinone esters.

G. Beutner, N. Yasuda, J. Kuethe, 2007, The Journal of organic chemistry.

Heterocyclic Synthesis via the Tandem Thionium/N-Acyliminium Ion Cascade.

A. Padwa, J. Kuethe, T. Heidelbaugh, 1998, The Journal of organic chemistry.

The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.

J. Metzger, G. Scapin, S. Xu, 2016, Bioorganic & medicinal chemistry letters.

Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.

Shirly Pinto, J. Lisnock, M. Garcia-Calvo, 2013, Bioorganic & medicinal chemistry letters.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Andreas Verras, Yang Yu, Edward C Sherer, 2017, Journal of medicinal chemistry.

A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.

Jeffrey T. Kuethe, D. Johns, P. Orth, 2021, Journal of medicinal chemistry.

Tandem Diels—Alder Cyclization/Aromatization Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones.

D. Comins, J. Kuethe, 2003 .

Tandem Diels-Alder cyclization/aromatization reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones

D. Comins, J. Kuethe, 2003 .

Diels-Alder reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: regio- and stereoselective synthesis of octahydroquinolines.

D. Comins, J. Kuethe, C. Brooks, 2003, Organic Letters.

Diels—Alder Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: Regio- and Stereoselective Synthesis of Octahydroquinolines.

D. Comins, J. Kuethe, C. Brooks, 2003 .

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, Jeffrey T. Kuethe, M. Struthers, 2015, ACS medicinal chemistry letters.

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

Jeffrey T. Kuethe, D. Johns, T. Tucker, 2023, Circulation.

Additive and Vinylogous Pummerer Reactions of Amido Sulfoxides and Their Use in the Preparation of Nitrogen Containing Heterocycles

J. Kuethe, Albert Padwa and, 1998 .

Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

John D. Schreier, Min Xu, D. Hazuda, 2016, Journal of Medicinal Chemistry.

Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles.

R. Orr, Louis-Charles Campeau, Matthew T. Tudge, 2014, Organic letters.

Development of a Palladium‐Catalyzed α‐Arylation of Cyclopropyl Nitriles.

J. Dunn, R. Orr, Louis-Charles Campeau, 2015 .