R. Fortin

发表

NOVEL 1,2-DIARYLCYCLOBUTENES : SELECTIVE AND ORALLY ACTIVE COX-2 INHIBITORS

D. Riendeau, C. Chan, W. Cromlish, 1996 .

L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.

R. Young, D. Denis, D. Éthier, 1986, Canadian journal of physiology and pharmacology.

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

D. Denis, C. Chan, S. Charleson, 1989, Canadian journal of physiology and pharmacology.

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.

D. Riendeau, D. Denis, P. Prasit, 1992, Canadian journal of physiology and pharmacology.

5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.

P. Prasit, J. Evans, J. Gauthier, 1991, Molecular pharmacology.

Leukotrienes and Asthma

R. Dixon, J. Metzger, D. Riendeau, 1992 .

Identification of a new biaryl scaffold generating potent renin inhibitors.

C. Bayly, D. McKay, R. Aspiotis, 2010, Bioorganic & medicinal chemistry letters.

L-648,051: an aerosol active leukotriene D4 receptor antagonist.

D. Denis, D. Éthier, A. Ford-hutchinson, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

Therapeutic potential of 5-lipoxygenase inhibitors: the discovery and development of MK-886, a novel-mechanism leukotriene inhibitor

R. Dixon, C. Yoakim, C. Rouzer, 1992 .

Identification and isolation of a membrane protein necessary for leukotriene production

Jilly F. Evans, Jacques Yves Gauthier, Irving S. Sigal, 1990, Nature.

Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist.

D. Éthier, J. Evans, A. Ford-hutchinson, 1987, European journal of pharmacology.

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Yongxin Han, R. Zamboni, P. Tawa, 2007, Bioorganic & medicinal chemistry letters.

A new class of leukotriene biosynthesis inhibitors: The discovery of MK0591

D. Riendeau, R. Young, P. Prasit, 1992 .

2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.

D. Riendeau, C. Brideau, C. Chan, 1999, Bioorganic & medicinal chemistry letters.

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.

J. Falgueyret, D. Riendeau, C. Brideau, 1996, Journal of medicinal chemistry.

tert-Butylmethoxyphenylsilyl ether-a new selective, stable alcohol protecting group with remarkable lability to fluoride

C. Yoakim, J. Gillard, Y. Guindon, 1984 .

Direct synthesis of thio ethers from thiols and alcohols

J. Rokach, R. Frenette, Y. Guindon, 1983 .

The unsymmetrical silaketal as a neutral, removable tether for effecting intramolecular diels-alder reactions.

M. Bernstein, J. Gillard, R. Glaser, 1991 .

The total, stereocontrolled synthesis of a chemical precursor to (+)-thienamycin. A formal synthesis of the antibiotic

S. Hanessian, R. Fortin, D. Désilets, 1982 .

Symmetrical alkoxysilyl ethers. A new class of alcohol-protecting groups. Preparation of tert-butoxydiphenylsilyl ethers

C. Yoakim, J. Gillard, Y. Guindon, 1988 .

2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.

R Gordon, R Fortin, D. Riendeau, 1998, Bioorganic & medicinal chemistry letters.

Direct synthesis of thio ethers from thiols and alcohols

J. Rokach, R. Frenette, Y. Guindon, 1983 .

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.

P. Clark, Steve Rowland, D. Denis, 2008, Bioorganic & medicinal chemistry letters.

Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.

J. Falgueyret, D. Riendeau, C. Brideau, 1993, Journal of medicinal chemistry.

Novel 1,2‐Diarylcyclobutenes: Selective and Orally Active COX‐2 Inhibitors.

D. Riendeau, W. Cromlish, R. Gordon, 1997 .