Stephen N. Greszler

发表

Desymmetrization of pibrentasvir for efficient prodrug synthesis†

J. Randolph, Jan E. Waters, E. Voight, 2021, Chemical science.

Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α-Arylation of Reformatsky Reagents.

E. Voight, Stephen N. Greszler, Geoff T. Halvorsen, 2017, Organic letters.

Discovery and SAR of 4-Aminopyrrolidine-2-carboxylic Acid Correctors of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, A. Swensen, Ashvani K. Singh, 2022, Bioorganic & medicinal chemistry letters.

Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale

J. Kallemeyn, Stephen N. Greszler, J. Hartung, 2019, Organic Process Research & Development.

Asymmetric synthesis of dihydroindanes by convergent alkoxide-directed metallacycle-mediated bond formation.

G. C. Micalizio, Stephen N. Greszler, H. Reichard, 2012, Journal of the American Chemical Society.

Diastereoselective synthesis of pentasubstituted gamma-butyrolactones from silyl glyoxylates and ketones through a double Reformatsky reaction.

Stephen N. Greszler, Jeffrey S. Johnson, 2009, Angewandte Chemie.

Silyl glyoxylates. Conception and realization of flexible conjunctive reagents for multicomponent coupling.

David A. Nicewicz, D. Nicewicz, Daniel C. Schmitt, 2012, The Journal of organic chemistry.

Remote stereoinduction in the acylation of fully substituted enolates: tandem Reformatsky/quaternary Claisen condensations of silyl glyoxylates and β-lactones.

J. Malinowski, Stephen N. Greszler, Jeffrey S. Johnson, 2010, Journal of the American Chemical Society.

Formal synthesis of leustroducsin B via Reformatsky/Claisen condensation of silyl glyoxylates.

J. Malinowski, Stephen N. Greszler, Jeffrey S. Johnson, 2011, Organic letters.

Synthesis of the Cortistatin Pentacyclic Core by Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling.

G. C. Micalizio, Stephen N. Greszler, Claudio Aquino, 2016, Organic letters.

Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives.

Elliot P Farney, G. Gfesser, E. Voight, 2021, The Journal of organic chemistry.

Desymmetrization of pibrentasvir for efficient prodrug synthesis†

J. Randolph, Jan E. Waters, E. Voight, 2021, Chemical science.

General Asymmetric Synthesis of Densely Functionalized Pyrrolidines via Endo-Selective [3+2] Cycloaddition of β-Quaternary-Substituted Nitroalkenes and Azomethine Ylides.

E. Voight, Stephen N. Greszler, Gang Zhao, 2020, The Journal of organic chemistry.

Synthesis of A-9758, an Inverse Agonist of Retinoic Acid-Related Orphan Receptor γt

C. C. Marvin, E. Voight, Stephen N. Greszler, 2022, ACS omega.

Catalytic redox-initiated glycolate aldol additions of silyl glyoxylates.

Stephen N. Greszler, Jeffrey S. Johnson, 2009, Organic letters.

Fueling the Pipeline via Innovations in Organic Synthesis.

P. Kym, E. Voight, Stephen N. Greszler, 2021, ACS medicinal chemistry letters.

Synthesis of ABBV-168, a 2'-Bromouridine for the Treatment of Hepatitis C.

Michael T. Tudesco, Eric G. Moschetta, N. Ide, 2018, The Journal of organic chemistry.

Prodrug Strategies to Improve the Solubility of HCV NS5A Inhibitor Pibrentasvir (ABT-530).

Brice E. Uno, J. Randolph, Deanne F. Stolarik, 2020, Journal of medicinal chemistry.

Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2018, Journal of medicinal chemistry.

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2019, ACS medicinal chemistry letters.

Enabling Synthesis of ABBV-2222, A CFTR Corrector for the Treatment of Cystic Fibrosis.

E. Voight, Stephen N. Greszler, Bhadra H. Shelat, 2019, Organic letters.

Enabling Asymmetric Synthesis of ABBV-3748, a Corrector Compound for the Treatment of Cystic Fibrosis.

E. Voight, Stephen N. Greszler, Bhadra H. Shelat, 2022, Organic letters.

Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α-Arylation of Reformatsky Reagents.

E. Voight, Stephen N. Greszler, Geoff T. Halvorsen, 2017, Organic Letters.