N. Curtis

发表

Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers

Anna L. Dunn, Bernie O’Hare, P. Liu, 2018, Organometallics.

Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.

M. Beer, J. Kulagowski, C. Thomson, 2004, Bioorganic & medicinal chemistry letters.

SYNTHESIS OF (-)-GLOEOSPORONE

A. Holmes, M. Looney, N. Pearson, 1991 .

Synthetic methodology for the preparation of trans- and cis-2,9-disubstituted oxonanes

A. Holmes, R. Carling, N. Curtis, 1989 .

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

J. Kemp, P. Leeson, Brett Williams, 1991, Journal of medicinal chemistry.

Cyclic peptides as selective tachykinin antagonists.

D. Veber, J. Maguire, B. Williams, 1993, Journal of medicinal chemistry.

Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor

M. Gray, S. Leach, N. Curtis, 2015 .

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.

P. Leeson, S. Freedman, S. Patel, 1999, Bioorganic & medicinal chemistry letters.

An intramolecular hydrosilation approach to hexahydrooxonins related to obtusenyne. Effect of catalyst and conditions on stereoselectivity

A. Holmes, N. Curtis, 1992 .

Studies towards the synthesis of obtusenyne. Synthesis of the hexahydrooxonin nucleus

A. Holmes, M. Looney, N. Curtis, 1992 .

Studies towards the synthesis of obtusenyne. A Claisen rearrangement approach to unsaturated nine-membered lactones.

A. Holmes, M. Looney, N. Curtis, 1991 .

3′‐(Arylmethyl)‐ and 3′‐(Aryloxy)‐3‐phenyl‐4‐hydroxyquinolin‐2(1H)‐ ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor.

J. Kemp, P. Leeson, M. Tricklebank, 2010 .

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

P. Leeson, I. Stansfield, M. Rowley, 1994, Journal of medicinal chemistry.

Synthetic Methodology for the Preparation of trans- and cis-2,9-Disubstituted Oxonanes.

A. Holmes, R. Carling, N. Curtis, 1990 .

A facile gold(I)-catalysed intramolecular alkyne hydroarylation approach to methyl 5-amino-2H-1-benzopyran-8-carboxylate derivatives

N. Curtis, J. Prodger, Geracimos Rassias, 2008 .

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

P D Leeson, P. Leeson, C. Ragan, 1996, Journal of medicinal chemistry.

Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist

Neil G. Stevenson, M. Gray, N. Curtis, 2010 .

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.

K. Wafford, S. Grimwood, F. Murray, 2003, Bioorganic & medicinal chemistry letters.

Stereocontrolled syntheses of epimeric 3-aryl-6-phenyl-1-oxa-7-azaspiro(4.5)decane NK-1 receptor antagonist precursors.

C. Swain, B. Williams, J. Kulagowski, 2001, Organic letters.

A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via Multistage Continuous Synthesis

Anna L. Dunn, K. Arrington, Ian P. Andrews, 2020 .

Synthesis of (+)-obtusenyne.

M. Congreve, J. Davies, A. Holmes, 2008, Chemistry.

Development of NK-2 selective antagonists

J. Maguire, B. Williams, A. McKnight, 1988, Regulatory Peptides.

Conformationally constrained tachykinin analogs which are selective ligands for the eledoisin binding site.

D. Veber, R. Freidinger, J. Maguire, 1986, Molecular pharmacology.

Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder

N. Curtis, N. Suman-Chauhan, D. Bristow, 1987, British journal of pharmacology.

Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

P. Leeson, M. Rowley, S. Grimwood, 1996 .

Characterization of Tachykinin Receptors by Ligand Binding Studies and by Utilization of Conformationally Restricted Tachykinin Analogues

D. Veber, R. Freidinger, B. Williams, 1986 .

Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors

L. Bristow, Smita Patel, G. Cook, 1998, Neuropharmacology.

L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.

P. Leeson, C. Ragan, M. Tricklebank, 1997, The Journal of pharmacology and experimental therapeutics.

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

P. Leeson, M. Knowles, G. Mcallister, 1997, The Journal of pharmacology and experimental therapeutics.

Orally efficacious NR2B-selective NMDA receptor antagonists.

Kenneth D Anderson, R. Freidinger, N. Liverton, 2003, Bioorganic & medicinal chemistry letters.

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

R. Mortishire-Smith, U. Gerhard, Sanjeev Kumar, 2002, Drug Metabolism And Disposition.

Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.

P. Leeson, S. Freedman, S. Patel, 1996, Molecular pharmacology.

Synthesis of (+)-obtusenyne.

M. Congreve, J. Davies, A. Holmes, 2008, Chemistry.

8-Azabicyclo[3.2.1]oct-3-en-2-ones via asymmetric 1,3-dipolar cycloaddition of a homochiral 3-oxidopyridinium betaine

R. Ball, J. Kulagowski, N. Curtis, 2006 .