Qi Sun

发表

Drugging an undruggable pocket on KRAS

M. Koegl, S. Fesik, A. Waterson, 2019, Proceedings of the National Academy of Sciences.

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.

S. Fesik, A. Waterson, O. Rossanese, 2018, ACS medicinal chemistry letters.

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor

A. Waterson, D. Rudolph, M. Gmachl, 2022, Journal of medicinal chemistry.

WD Repeat Domain 43 promotes malignant progression of non-small cell lung cancer by regulating CDK2.

J. Dai, Qi Sun, Haijun Sun, 2022, The international journal of biochemistry & cell biology.

Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers

M. Koegl, S. Fesik, A. Waterson, 2020, Proceedings of the National Academy of Sciences.

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

E. Olejniczak, S. Fesik, O. Rossanese, 2018, Journal of medicinal chemistry.

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

S. Fesik, A. Waterson, O. Rossanese, 2018, Journal of medicinal chemistry.

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

E. Olejniczak, S. Fesik, A. Waterson, 2014, Proceedings of the National Academy of Sciences.

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Qi Sun, Zhongming Zhao, Zhongming Zhao, 2015, Molecular cell.

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.

S. Fesik, A. Waterson, O. Rossanese, 2018, Analytical biochemistry.

A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand

E. Olejniczak, S. Fesik, A. Friberg, 2014, Journal of Biomolecular NMR.

Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

Qi Sun, Stephen W. Fesik, Edward T. Olejniczak, 2012, Angewandte Chemie.

Interaction with WDR 5 Pro motes Target Gene Recognition and Tumorigenesis by MYC Graphical

Zhongming Zhao, E. Olejniczak, S. Fesik, 2015 .

Fragment-based screening of programmed death ligand 1 (PD-L1).

E. Olejniczak, S. Fesik, Bin Zhao, 2019, Bioorganic & medicinal chemistry letters.

A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand

E. Olejniczak, S. Fesik, A. Friberg, 2014, Journal of Biomolecular NMR.

PD-L1 IgV domain V76T with fragment

E. Olejniczak, S. Fesik, Bin Zhao, 2019 .

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

E. Olejniczak, S. Fesik, C. M. Eischen, 2015, Molecular cell.