B. Altvater

发表

Activated Human γδ T Cells as Stimulators of Specific CD8+ T-cell Responses to Subdominant Epstein Barr Virus Epitopes: Potential for Immunotherapy of Cancer

C. Bollard, A. Moosmann, C. Rossig, 2009, Journal of immunotherapy.

NK cells are dysfunctional in human chronic myelogenous leukemia before and on imatinib treatment and in BCR–ABL-positive mice

J. Gerss, H. Maecker, S. Koschmieder, 2012, Leukemia.

Zoledronic acid negatively affects the expansion of in vitro activated human NK cells and their cytolytic interactions with Ewing sarcoma cells.

U. Dirksen, C. Rossig, H. Juergens, 2013, Oncology reports.

High Proportions of CD4+ T Cells among Residual Bone Marrow T Cells in Childhood Acute Lymphoblastic Leukemia Are Associated with Favorable Early Responses

C. Rossig, M. Ahlmann, A. Rosemann, 2013, Acta Haematologica.

A high proportion of bone marrow T cells with regulatory phenotype (CD4+CD25hiFoxP3+) in Ewing sarcoma patients is associated with metastatic disease

U. Dirksen, C. Rossig, H. Juergens, 2009, International journal of cancer.

Vaccination to improve the persistence of CD19CAR gene-modified T cells in relapsed pediatric acute lymphoblastic leukemia

A. Hackshaw, P. Veys, B. Dréno, 2017, Leukemia.

T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G

U. Dirksen, E. Wardelmann, M. Fluegge, 2017, Oncotarget.

Gene-engineered varicella-zoster virus reactive CD4+ cytotoxic T cells exert tumor-specific effector function.

C. Rooney, B. Eing, C. Rossig, 2007, Cancer research.

Overcoming Heterogeneity of Antigen Expression for Effective CAR T Cell Targeting of Cancers

C. Rossig, B. Altvater, S. Kailayangiri, 2020, Cancers.

The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies

C. Rossig, B. Altvater, S. Kailayangiri, 2022, Cancers.

Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers

C. Rossig, B. Altvater, S. Kailayangiri, 2018, Front. Oncol..

Targeting Interleukin-2 to the Bone Marrow Stroma for Therapy of Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation

E. Wardelmann, M. Schäfers, G. Köhler, 2014, Cancer Immunology Research.

Target Antigen Expression on a Professional Antigen-Presenting Cell Induces Superior Proliferative Antitumor T-Cell Responses via Chimeric T-Cell Receptors

C. Rooney, H. Jürgens, M. Brenner, 2006, Journal of immunotherapy.

CD28 co‐stimulation via tumour‐specific chimaeric receptors induces an incomplete activation response in Epstein–Barr virus‐specific effector memory T cells

C. Rossig, H. Juergens, J. Vormoor, 2006, Clinical and experimental immunology.

2B4 (CD244) signaling via chimeric receptors costimulates tumor-antigen specific proliferation and in vitro expansion of human T cells

C. Rossig, H. Juergens, M. Pule, 2009, Cancer Immunology, Immunotherapy.

GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD2 and Releasing Inducible IL-18

A. Schambach, R. Blasczyk, B. Eiz-Vesper, 2022, Frontiers in Immunology.

Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

M. Fluegge, H. Wiendl, A. Jacobs, 2017, Oncoimmunology.

Surface expression of the immunotherapeutic target GD2 in osteosarcoma depends on cell confluency

C. Rossig, K. Grobe, B. Altvater, 2021, Cancer reports.

PD-1 checkpoint blockade in patients with relapsed AML after allogeneic stem cell transplantation

M. Lohoff, W. Berdel, W. Hartmann, 2017, Bone Marrow Transplantation.

Anchorage-independent growth of Ewing sarcoma cells under serum-free conditions is not associated with stem-cell like phenotype and function.

U. Dirksen, J. Hardes, C. Rossig, 2014, Oncology reports.

Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo

N. Sebire, M. Hotfilder, C. Rossig, 2010, Leukemia.

Cancer Therapy : Preclinical 2 B 4 ( CD 244 ) Signaling by Recombinant Antigen-specific Chimeric Receptors Costimulates Natural Killer Cell Activation to Leukemia and Neuroblastoma Cells

D. Campana, C. Rossig, H. Juergens, 2009 .

2B4 (CD244) Signaling by Recombinant Antigen-specific Chimeric Receptors Costimulates Natural Killer Cell Activation to Leukemia and Neuroblastoma Cells

D. Campana, C. Rossig, H. Juergens, 2009, Clinical Cancer Research.

HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells

W. Hartmann, D. Görlich, C. Rossig, 2021, Cancers.

Phase I study of F16IL2 antibody–cytokine fusion with very low‐dose araC in acute myeloid leukaemia relapse after allogeneic stem cell transplantation

G. Lenz, M. Schäfers, W. Berdel, 2021, British journal of haematology.

Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma

U. Dirksen, T. Budde, A. Schwab, 2022, Cancers.

Activated human γδ T cells induce peptide-specific CD8+ T-cell responses to tumor-associated self-antigens

C. Rossig, H. Juergens, B. Savoldo, 2012, Cancer Immunology, Immunotherapy.

Using stroma-anchoring cytokines to augment ADCC: a phase 1 trial of F16IL2 and BI 836858 for posttransplant AML relapse

G. Lenz, M. Schäfers, W. Berdel, 2022, Blood advances.

Adoptive Cellular Immunotherapy with CD19-Specific T Cells

H. Jürgens, C. Rossig, J. Vormoor, 2005, Klinische Padiatrie.

Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-GD2 CAR Expression and Inducible Cytokines

A. Schambach, I. Sandalcioglu, B. Eiz-Vesper, 2020, Cancers.

Requirement for YAP1 signaling in myxoid liposarcoma

S. Fröhling, E. Wardelmann, M. Słabicki, 2019, EMBO molecular medicine.

Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma

E. Wardelmann, A. Krüger, P. Åman, 2019, Molecular Cancer Therapeutics.

FUS–DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma

S. Fröhling, E. Wardelmann, P. Åman, 2017, Clinical Cancer Research.

Programmed cell death ligand 1 (PD‐L1) expression is not a predominant feature in Ewing sarcomas

U. Dirksen, E. Wardelmann, W. Hartmann, 2018, Pediatric blood & cancer.

EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells.

M. Fluegge, W. Hartmann, K. Kerl, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

The ganglioside antigen GD2 is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting

U. Dirksen, J. Hardes, G. Gosheger, 2012, British Journal of Cancer.

Generation of an NFκB-Driven Alpharetroviral “All-in-One” Vector Construct as a Potent Tool for CAR NK Cell Therapy

A. Schambach, I. Sandalcioglu, Johann Meyer, 2021, Frontiers in Immunology.

SS18-SSX–Dependent YAP/TAZ Signaling in Synovial Sarcoma

O. Larsson, E. Wardelmann, W. Hartmann, 2019, Clinical Cancer Research.

Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies

M. Wagenmann, D. Reinhardt, A. Rettie, 2016, Gene Therapy.

Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals

J. Hardes, G. Gosheger, C. Rossig, 2014, Cancer Immunology, Immunotherapy.

VEGFR2 as a target for CAR T cell therapy of Ewing sarcoma

W. Hartmann, C. Rossig, B. Altvater, 2020, Pediatric blood & cancer.

Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging

M. Hotfilder, C. Faber, V. Vieth, 2013, British Journal of Cancer.

Insulin‐like growth factor‐1 receptor (IGF‐1R) inhibition promotes expansion of human NK cells which maintain their potent antitumor activity against Ewing sarcoma cells

C. Rossig, B. Altvater, S. Kailayangiri, 2015, Pediatric blood & cancer.

Requirement for YAP1 signaling in myxoid liposarcoma

S. Fröhling, E. Wardelmann, C. Scholl, 2019, EMBO molecular medicine.

Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

M. Fluegge, H. Wiendl, A. Jacobs, 2017, Oncoimmunology.

A high proportion of bone marrow T cells with regulatory phenotype (CD4+CD25hiFoxP3+) in Ewing sarcoma patients is associated with metastatic disease

U. Dirksen, C. Rossig, H. Juergens, 2009, International journal of cancer.

CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

A. Schambach, W. Berdel, W. Hartmann, 2023, Cancer Gene Therapy.